Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies

MicroRNA‐181a Regulates Local Immune Balance by Inhibiting Proliferation and Immunosuppressive Properties of Mesenchymal Stem Cells

“…We previously reported that miR-181a expression was significantly increased in placental samples from women with severe PE [18]. This result was confirmed in two subsequent reports [19,20]. miR-181a is strongly expressed in bone marrow (BM) and thymus, can modulate hematopoietic lineage differentiation, and has an important role during T-and B-cell development [21][22][23].…”

The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1)

“…15,17,18 In recent years, specific microRNAs profile has been reported in human placenta, and many differential miRNAs are found in placentas from those who suffer from preeclampsia. 19,20 The dys-regulated miRNAs expression in preeclamptic placenta suggests that these small molecules may play certain roles in placenta development. 21,22 We previously reported that PE placentas exhibited lower mRNA expression and hypermethylation in promoter region of H19 gene compared with normal placentas.…”

miR-210 Targets Iron-Sulfur Cluster Scaffold Homologue in Human Trophoblast Cell Lines

“…18,19 Growing evidence indicates that miRNA expression profiles define clinicopathological phenotypes of various human disorders. 20 -26 Two recent studies 27,28 have shown up-regulation of placental miR-210 as a distinct feature of preterm or severe preeclampsia, suggesting a role for miRNAs in the regulation of altered placental gene expression in preeclampsia. Not surprisingly, miR-210 is known as a master miRNA of hypoxic response, a common component of the tumor microenvironment.…”