Differential expression profile of plasma exosomal microRNAs in acute type A aortic dissection with acute lung injury

Zhang, Chiyuan; Bai, Hui; Zhang, Lei; Zhang, Yanfeng; Chen, Xuliang; Shi, Ruizheng; Zhang, Guogang; Xu, Qian; Lin, Guo‐Qiang

doi:10.1038/s41598-022-15859-3

Cited by 5 publications

(3 citation statements)

References 64 publications

(62 reference statements)

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“…Furthermore, within the cohort of patients with acute type A aortic dissection, plasm EVs from individuals with acute lung injury showed upregulation of miR-485 and downregulation of miR-206 compared to those without acute lung injury. This observation suggests the potential of miR-485 and miR-206 to serve as a marker for acute lung damage in individuals suffering from acute An aortic dissection (137).…”

Section: Ev-associated Ncrnas Involved In Both Conditions Demonstrate...mentioning

confidence: 82%

Extracellular vesicles as carriers for noncoding RNA-based regulation of macrophage/microglia polarization: an emerging candidate regulator for lung and traumatic brain injuries

Chen,

Zhang,

Pan

et al. 2024

Front. Immunol.

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Macrophage/microglia function as immune defense and homeostatic cells that originate from bone marrow progenitor cells. Macrophage/microglia activation is historically divided into proinflammatory M1 or anti-inflammatory M2 states based on intracellular dynamics and protein production. The polarization of macrophages/microglia involves a pivotal impact in modulating the development of inflammatory disorders, namely lung and traumatic brain injuries. Recent evidence indicates shared signaling pathways in lung and traumatic brain injuries, regulated through non-coding RNAs (ncRNAs) loaded into extracellular vesicles (EVs). This packaging protects ncRNAs from degradation. These vesicles are subcellular components released through a paracellular mechanism, constituting a group of nanoparticles that involve exosomes, microvesicles, and apoptotic bodies. EVs are characterized by a double-layered membrane and are abound with proteins, nucleic acids, and other bioactive compounds. ncRNAs are RNA molecules with functional roles, despite their absence of coding capacity. They actively participate in the regulation of mRNA expression and function through various mechanisms. Recent studies pointed out that selective packaging of ncRNAs into EVs plays a role in modulating distinct facets of macrophage/microglia polarization, under conditions of lung and traumatic brain injuries. This study will explore the latest findings regarding the role of EVs in the progression of lung and traumatic brain injuries, with a specific focus on the involvement of ncRNAs within these vesicles. The conclusion of this review will emphasize the clinical opportunities presented by EV-ncRNAs, underscoring their potential functions as both biomarkers and targets for therapeutic interventions.

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Section: Ev-associated Ncrnas Involved In Both Conditions Demonstrate...mentioning

confidence: 82%

Extracellular vesicles as carriers for noncoding RNA-based regulation of macrophage/microglia polarization: an emerging candidate regulator for lung and traumatic brain injuries

Chen,

Zhang,

Pan

et al. 2024

Front. Immunol.

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“…Local vascular inflammation due to intimal tear and pseudotumor formation in acute type A aortic dissection (ATAAD) can progress to systemic inflammatory syndrome, leading to ALI. miR-485 was upregulated, and miR-206 was downregulated in plasma exosomes of patients with ALI compared with those with ATAAD without ALI and is expected to be a marker of ALI in patients with ATAAD …”

Section: Role Of Exosomal Mirnas In the Diagnosis Of Alimentioning

confidence: 99%

“…miR-485 was upregulated, and miR-206 was downregulated in plasma exosomes of patients with ALI compared with those with ATAAD without ALI and is expected to be a marker of ALI in patients with ATAAD. 169 …”

Section: Role Of Exosomal Mirnas In the Diagnosis Of Alimentioning

confidence: 99%

Exosomal MicroRNAs: An Emerging Important Regulator in Acute Lung Injury

Lan,

Dong,

Yang

et al. 2023

ACS Omega

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Acute lung injury (ALI) is a clinically life-threatening form of respiratory failure with a mortality of 30%–40%. Acute respiratory distress syndrome is the aggravated form of ALI. Exosomes are extracellular lipid vesicles ubiquitous in human biofluids with a diameter of 30–150 nm. They can serve as carriers to convey their internal cargo, particularly microRNA (miRNA), to the target cells involved in cellular communication. In disease states, the quantities of exosomes and the cargo generated by cells are altered. These exosomes subsequently function as autocrine or paracrine signals to nearby or distant cells, regulating various pathogenic processes. Moreover, exosomal miRNAs from multiple stem cells can provide therapeutic value for ALI by regulating different signaling pathways. In addition, changes in exosomal miRNAs of biofluids can serve as biomarkers for the early diagnosis of ALI. This study aimed to review the role of exosomal miRNAs produced by different sources participating in various pathological processes of ALI and explore their potential significance in the treatment and diagnosis.

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3D‐hUMSCs Exosomes Ameliorate Vitiligo by Simultaneously Potentiating Treg Cells‐Mediated Immunosuppression and Suppressing Oxidative Stress‐Induced Melanocyte Damage

Wang,

Guo,

Niu

et al. 2024

Advanced Science

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Vitiligo is an autoimmune disease characterized by epidermal melanocyte destruction, with abnormal autoimmune responses and excessive oxidative stress as two cardinal mechanisms. Human umbilical mesenchymal stem cells‐derived exosomes (hUMSCs‐Exos) are regarded as promising therapeutic choice for autoimmune diseases due to potent immunosuppressive and anti‐oxidative properties, which can be potentiated under 3D cell culture condition. Nevertheless, whether exosomes derived from 3D spheroids of hUMSCs (3D‐Exos) exhibit considerable therapeutic effect on vitiligo and the underlying mechanism remain elusive. In this study, systemic administration of 3D‐Exos showed a remarkable effect in treating mice with vitiligo, as revealed by ameliorated skin depigmentation, less CD8+T cells infiltration, and expanded Treg cells in skin, and 3D‐Exos exerted a better effect than 2D‐Exos. Mechanistically, 3D‐Exos can prominently facilitate the expansion of Treg cells in vitiligo lesion and suppress H2O2‐induced melanocytes apoptosis. Forward miRNA profile analysis and molecular experiments have demonstrated that miR‐132‐3p and miR‐125b‐5p enriched in 3D‐Exos greatly contributed to these biological effects by targeting Sirt1 and Bak1 respectively. In aggregate, 3D‐Exos can efficiently ameliorate vitiligo by simultaneously potentiating Treg cells‐mediated immunosuppression and suppressing oxidative stress‐induced melanocyte damage via the delivery of miR‐132‐3p and miR‐125b‐5p. The employment of 3D‐Exos will be a promising treament for vitiligo.

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Differential expression profile of plasma exosomal microRNAs in acute type A aortic dissection with acute lung injury

Cited by 5 publications

References 64 publications

Extracellular vesicles as carriers for noncoding RNA-based regulation of macrophage/microglia polarization: an emerging candidate regulator for lung and traumatic brain injuries

Extracellular vesicles as carriers for noncoding RNA-based regulation of macrophage/microglia polarization: an emerging candidate regulator for lung and traumatic brain injuries

Exosomal MicroRNAs: An Emerging Important Regulator in Acute Lung Injury

3D‐hUMSCs Exosomes Ameliorate Vitiligo by Simultaneously Potentiating Treg Cells‐Mediated Immunosuppression and Suppressing Oxidative Stress‐Induced Melanocyte Damage

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