Differential functional connectivity within an emotion regulation neural network among individuals resilient and susceptible to the depressogenic effects of early life stress

Cisler, Josh M.; James, G. Andrew; Tripathi, Shanti P.; Mletzko, Tanja; Heim, Christine; Hu, Xiaoping; Mayberg, Helen S.; Nemeroff, Charles B.; Kilts, Clinton D.

doi:10.1017/s0033291712001390

Cited by 214 publications

(129 citation statements)

References 56 publications

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“…In our case the seed region was a 6-mm-diameter sphere centered on a point with MNI coordinates (x= 1, y= 25, z= -11), designed to encompass the sgACC. These MNI coordinates were selected following the recent paper of Cisler et al (2013), defining centroids of nodes comprising an affective cognitive network. To combine results across subjects and compute statistical significance, Fisher's r-to-Z transformation was used to convert these correlation maps into Z-maps characterizing the rsFC of the seed region in each point.…”

Section: Imaging Datamentioning

confidence: 99%

“…Major depression can be conceptualized as a neural-network-level disease, involving functional connectivity deregulation in the prefrontal and limbic areas (Sheline et al 2010;Carballedo et al 2011). Recent research (Fox and Greicius 2010;Veer et al 2010;Marchetti et al 2012;Fox et al 2012 a, b;Cisler et al 2013) has focused on this deregulated FC. The combination of rTMS and functional connectivity MRI (fcMRI) may significantly contribute to the diagnosis and treatment of psychiatric illnesses with 5 deregulated network pathologies such as major depression (Fox et al 2012 b).…”

Section: Introductionmentioning

confidence: 99%

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Accelerated HF-rTMS in treatment-resistant unipolar depression: Insights from subgenual anterior cingulate functional connectivity

Baeken¹,

Marinazzo²,

Wu³

et al. 2014

The World Journal of Biological Psychiatry

157

130

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Section: Imaging Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Accelerated HF-rTMS in treatment-resistant unipolar depression: Insights from subgenual anterior cingulate functional connectivity

Baeken¹,

Marinazzo²,

Wu³

et al. 2014

The World Journal of Biological Psychiatry

157

130

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“…Symptomatic adults reporting a history of maltreatment during childhood show altered local connectivity and hub-like properties of the amygdala and PFC (23), decreased functional connectivity strength of the PFC (24), and decreased functional connectivity of the amygdala with neighboring limbic areas (25). However, to our knowledge, no studies have investigated how maltreatment during childhood may affect brain Significance Childhood maltreatment is a major risk factor for internalizing disorders including depression and anxiety, which cause significant disability.…”

mentioning

confidence: 99%

Childhood maltreatment is associated with altered fear circuitry and increased internalizing symptoms by late adolescence

Herringa

Birn

Ruttle

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

364

314

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Maltreatment during childhood is a major risk factor for anxiety and depression, which are major public health problems. However, the underlying brain mechanism linking maltreatment and internalizing disorders remains poorly understood. Maltreatment may alter the activation of fear circuitry, but little is known about its impact on the connectivity of this circuitry in adolescence and whether such brain changes actually lead to internalizing symptoms. We examined the associations between experiences of maltreatment during childhood, resting-state functional brain connectivity (rs-FC) of the amygdala and hippocampus, and internalizing symptoms in 64 adolescents participating in a longitudinal community study. Childhood experiences of maltreatment were associated with lower hippocampus-subgenual cingulate rs-FC in both adolescent females and males and lower amygdalasubgenual cingulate rs-FC in females only. Furthermore, rs-FC mediated the association of maltreatment during childhood with adolescent internalizing symptoms. Thus, maltreatment in childhood, even at the lower severity levels found in a community sample, may alter the regulatory capacity of the brain's fear circuit, leading to increased internalizing symptoms by late adolescence. These findings highlight the importance of fronto-hippocampal connectivity for both sexes in internalizing symptoms following maltreatment in childhood. Furthermore, the impact of maltreatment during childhood on both fronto-amygdala and -hippocampal connectivity in females may help explain their higher risk for internalizing disorders such as anxiety and depression.child maltreatment | sex differences | ventromedial prefrontal cortex I n both clinical and community samples, maltreatment during childhood represents one of the strongest risk factors for developing depression and anxiety (1-3). Childhood maltreatment and other adversities account for up to a third of the risk for mood and anxiety disorders (4). Further, depression and anxiety disorders are major public health problems, affecting 15 and 32% of youth, respectively, by the age of 18 y (5). The burden of these disorders is significant, representing the second and fifth leading causes, respectively, of years lived with disability in the United States (6). Some evidence suggests that maltreatment may impart greater risk for the development of internalizing symptoms in females than in males (e.g., refs. 7-9). This differential risk could account, in part, for the higher incidence of internalizing problems in females than in males (10, 11). However, the neurobiological pathways from maltreatment during childhood to the expression of internalizing problems, including potential differences for females and males, remain poorly understood. Such information is crucial for improving the treatment of depression and anxiety disorders and for mitigating the effects of maltreatment during childhood.Both maltreatment during childhood (12) and internalizing disorders (13, 14) have been associated with altered activity in specific b...

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“…Functional connectivity was estimated by PPI, 40 using the generalized form of context-dependent gPPI (http://brainmap.wisc.edu/PPI). 42,77 Amygdala voxels used for connectivity analyses were selected using a combination of functional and anatomical approaches. 78 Voxels showing the strongest task-related effect across groups were identified using univariate fMRI analyses and results were examined within an amygdala region of interest (ROI) generated using the automated anatomical labeling (AAL) atlas.…”

Section: Connectivity Analysismentioning

confidence: 99%

Disconnection Between Amygdala and Medial Prefrontal Cortex in Psychotic Disorders

Mukherjee

Sabharwal

Kotov

et al. 2016

SCHBUL

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Distracting emotional information impairs attention more in schizophrenia (SCZ) than in never-psychotic individuals. However, it is unclear whether this impairment and its neural circuitry is indicative generally of psychosis, or specifically of SCZ, and whether it is even more specific to certain SCZ symptoms (eg, deficit syndrome). It is also unclear if this abnormality contributes to impaired behavioral performance and real-world functioning. Functional imaging data were recorded while individuals with SCZ, bipolar disorder with psychosis (BDP) and no history of psychotic disorders (CON) attended to identity of faces while ignoring their emotional expressions. We examined group differences in functional connectivity between amygdala, involved in emotional evaluation, and sub-regions of medial prefrontal cortex (MPFC), involved in emotion regulation and cognitive control. Additionally, we examined correlation of this connectivity with deficit syndrome and real-world functioning. Behaviorally, SCZ showed the worst accuracy when matching the identity of emotional vs neutral faces. Neurally, SCZ showed lower amygdala-MPFC connectivity than BDP and CON. BPD did not differ from CON, neurally or behaviorally. In patients, reduced amygdala-MPFC connectivity during emotional distractors was related to worse emotional vs neutral accuracy, greater deficit syndrome severity, and unemployment. Thus, reduced amygdala-MPFC functional connectivity during emotional distractors reflects a deficit that is specific to SCZ. This reduction in connectivity is associated with worse clinical and real-world functioning. Overall, these findings provide support for the specificity and clinical utility of amygdala-MPFC functional connectivity as a potential neural marker of SCZ.

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Differential functional connectivity within an emotion regulation neural network among individuals resilient and susceptible to the depressogenic effects of early life stress

Abstract: These preliminary results suggest functional neural connectivity patterns specific to ELS exposure and resiliency versus susceptibility to the depressogenic effects of ELS exposure.

Cited by 214 publications

References 56 publications

Accelerated HF-rTMS in treatment-resistant unipolar depression: Insights from subgenual anterior cingulate functional connectivity

Accelerated HF-rTMS in treatment-resistant unipolar depression: Insights from subgenual anterior cingulate functional connectivity

Childhood maltreatment is associated with altered fear circuitry and increased internalizing symptoms by late adolescence

Disconnection Between Amygdala and Medial Prefrontal Cortex in Psychotic Disorders

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