Differential Gene Expression Profiles of Radioresistant Non–Small-Cell Lung Cancer Cell Lines Established by Fractionated Irradiation: Tumor Protein p53-Inducible Protein 3 Confers Sensitivity to Ionizing Radiation

Solute carrier protein family may involve in radiation-induced radioresistance of non-small cell lung cancer

“…In fact, differential gene expression profiles in radioresistant cancer cases or cancer cell lines, including lung, pancreatic, esophageal, and cervical, have been reported (Lee et al 2010;Xu et al 2008;Ogawa et al 2006b;Wong et al 2006;Fukuda et al 2004). In the current study, we focused on clarifying the molecular mechanisms underlying resistance to radiation.…”

Biomarkers in Lung Cancer: Integration with Radiogenomics Data

“…Tumor protein p53-inducible protein 3 (TP53I3) gene was significantly down-regulated in radioresistant H460R cells predicting a link to p53-dependent cell death signaling. Interestingly, mRNA expression of TP53I3 differed in X-rayirradiated H460 and H460R cells, and overexpression of TP53I3 significantly affected the cellular radiosensitivity of H460R cells [78]. These works showed that fractionated ionizing radiation can lead to the development of acquired radiation resistance across altered gene profiles.…”

Network-based approaches for anticancer therapy

“…The results indicated that numerous cellular networks, including modules for DNA repair, survival, apoptosis, cell cycle, cell migration, protein localization, RNA processing, antioxidant defense, inflammation and cell proliferation, are altered by radiation exposure and help determine tumor cell fate. For example, p53-related genes and DNA-damage response genes are generally activated by irradiation in susceptible lung cancer cells while the networks associated with these genes are disrupted in radioresistant lung cancer cells (60,62,63).…”