Differential hormonal regulation of leukemia inhibitory factor (LIF) in rabbit and mouse uterus

Yang, Zeng‐Ming; Chen, Dong-Bao; Le, S.-P.; Harper, M. J. K.

doi:10.1002/(sici)1098-2795(199604)43:4<470::aid-mrd9>3.0.co;2-m

Cited by 50 publications

(12 citation statements)

References 33 publications

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“…Both LIF mRNA and protein were expressed strongly in the mouse uterus at oestrus and on day 4 of pregnancy, which just precedes blastocyst implantation (Bhatt et al, 1991;Shen and Leder, 1992;Yang et al, 1995). LIF expression was also upregulated by oestrogen in ovariectomized mice (Stewart et al, 1992;Yang et al, 1996). LIF is essential for mouse implantation in the LIF mutation model (Stewart et al, 1992).…”

Section: Discussionsupporting

confidence: 91%

Basigin expression and hormonal regulation in the rat uterus during the peri-implantation period

Xiao¹

2002

Reproduction

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Section: Discussionsupporting

confidence: 91%

Basigin expression and hormonal regulation in the rat uterus during the peri-implantation period

Xiao¹

2002

Reproduction

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“…Lif is strongly expressed in the receptive uterus and stimulated by estrogen4748. Lif deficiency will lead to implantation failure49.…”

Section: Discussionmentioning

confidence: 99%

Impaired receptivity and decidualization in DHEA-induced PCOS mice

Song

et al. 2016

Sci Rep

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Polycystic ovary syndrome (PCOS), a complex endocrine disorder, is a leading cause of female infertility. An obvious reason for infertility in PCOS women is anovulation. However, success rate with high quality embryos selected by assisted reproduction techniques in PCOS patients still remain low with a high rate of early clinical pregnancy loss, suggesting a problem in uterine receptivity. Using a dehydroepiandrosterone-induced mouse model of PCOS, some potential causes of decreased fertility in PCOS patients were explored. In our study, ovulation problem also causes sterility in PCOS mice. After blastocysts from normal mice are transferred into uterine lumen of pseudopregnant PCOS mice, the rate of embryo implantation was reduced. In PCOS mouse uteri, the implantation-related genes are also dysregulated. Additionally, artificial decidualization is severely impaired in PCOS mice. The serum estrogen level is significantly higher in PCOS mice than vehicle control. The high level of estrogen and potentially impaired LIF-STAT3 pathway may lead to embryo implantation failure in PCOS mice. Although there are many studies about effects of PCOS on endometrium, both embryo transfer and artificial decidualization are applied to exclude the effects from ovulation and embryos in our study.

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“…In the mouse LIF appears to be regulated by oestradiol (Bhatt et al 1991, Yang et al 1996 and there is a close link between the surge of oestradiol required for implantation and the burst of LIF expression (Bhatt et al 1991), whereas in the rabbit, uterus LIF expression appears to be controlled by progesterone (Yang et al 1996). Likewise, in human endometrium LIF expression is maximal during the postovulatory phase when the endometrium is under the influence of progesterone.…”

Section: Expression and Localisation In Uterine Tissuementioning

confidence: 99%

Review: The role of leukaemia inhibitory factor in the establishment of pregnancy

Vogiagis

Salamonsen²

1999

Journal of Endocrinology

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Leukaemia inhibitory factor (LIF) is a pleiotrophic cytokine required for blastocyst implantation in mice. Uterine expression of LIF and that of its receptors has been demonstrated in a number of mammalian species indicating that LIF may have widespread importance in the establishment of pregnancy. The variations in the reaction of the uterus in preparation for and during implantation are considerable between species and understanding the differences and similarities assists in the interpretation of how this cytokine functions. Recent studies suggest that reduced endometrial LIF contributes to human infertility. Studies also demonstrate a potential role in placentation and fetal development. Thus, LIF has become an important cytokine warranting further investigation in the human. It is anticipated that when the mechanisms underlying normal embryonic and endometrial development are elucidated, fertility and infertility will be more precisely understood and hence able to be effectively controlled.

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Differential hormonal regulation of leukemia inhibitory factor (LIF) in rabbit and mouse uterus

Cited by 50 publications

References 33 publications

Basigin expression and hormonal regulation in the rat uterus during the peri-implantation period

Basigin expression and hormonal regulation in the rat uterus during the peri-implantation period

Impaired receptivity and decidualization in DHEA-induced PCOS mice

Review: The role of leukaemia inhibitory factor in the establishment of pregnancy

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