Differential impact of metabolic syndrome on arterial stiffness and wave reflections: Focus on distinct definitions

Vyssoulis, Gregory P.; Pietri, P; Karpanou, Eva A.; Vlachopoulos, Charalambos; Kyvelou, Stella‐Maria; Spanos, Panagiotis; Cokkinos, Dennis V.; Stefanadis, Christodoulos

doi:10.1016/j.ijcard.2008.08.005

Cited by 22 publications

(15 citation statements)

References 44 publications

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“…In accordance to this, administration of vasoactive substances will affect AIx and PWV differently [34]. Furthermore, the dissociation between PWV and AIx observed in our study has also been described in individuals with metabolic syndrome [35], a condition that is also present in a number of women who develop PE [23].…”

Section: Discussionsupporting

confidence: 90%

Maternal Arterial Stiffness in Women Who Subsequently Develop Pre-Eclampsia

et al. 2011

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Background/ObjectivesPre-eclampsia (PE) is associated with profound changes in the maternal cardiovascular system. The aim of the present study was to assess whether alterations in the maternal arterial stiffness precede the onset of PE in at risk women.Methodology/Principal FindingsThis was a cross sectional study involving 70 pregnant women with normal and 70 women with abnormal uterine artery Doppler examination at 22–24 weeks of gestation. All women had their arterial stiffness (augmentation index and pulse wave velocity of the carotid-femoral and carotid-radial parts of the arterial tree) assessed by applanation tonometry in the second trimester of pregnancy, at the time of the uterine artery Doppler imaging. Among the 140 women participating in the study 29 developed PE (PE group) and 111 did not (non-PE group). Compared to the non-PE group, women that developed PE had higher central systolic (94.9±8.6 mmHg vs 104.3±11.1 mmHg; p = <0.01) and diastolic (64.0±6.0 vs 72.4±9.1; p<0.01) blood pressures. All the arterial stiffness indices were adjusted for possible confounders and expressed as multiples of the median (MoM) of the non-PE group. The adjusted median augmentation index was similar between the two groups (p = 0.84). The adjusted median pulse wave velocities were higher in the PE group compared to the non-PE group (carotid-femoral: 1.10±0.14 MoMs vs 0.99±0.11 MoMs; p<0.01 and carotid-radial: 1.08±0.12 MoMs vs 1.0±0.11 MoMs; p<0.01).Conclusions/SignificanceIncreased maternal arterial stiffness, as assessed by pulse wave velocity, predates the development of PE in at risk women.

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Section: Discussionsupporting

confidence: 90%

Maternal Arterial Stiffness in Women Who Subsequently Develop Pre-Eclampsia

et al. 2011

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“…The estimates of MetS prevalence are controversial due to different criteria used for its definition. 20 The level of agreement among the current definitions of MetS is not encouraging. 21 In our study we found that, even among the same microalbumin quartile, patients with MetS according to GISSI score had significantly higher microalbumin levels.…”

Section: Resultsmentioning

confidence: 97%

“…The estimates of MetS prevalence are controversial due to different criteria used for its definition 20 . The level of agreement among the current definitions of MetS is not encouraging 21 .…”

Section: Discussionmentioning

confidence: 99%

Urine Albumin Excretion, Within Normal Range, Reflects Increasing Prevalence of Metabolic Syndrome in Patients With Essential Hypertension

Vyssoulis

Karpanou

Spanos

et al. 2010

J of Clinical Hypertension

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J Clin Hypertens(Greenwich). 2010;12:597–602. © 2010 Wiley Periodicals, Inc. Microalbuminuria is a prognostic marker of cardiovascular disease and is related to metabolic syndrome (MetS). For this purpose, the authors examined the relationship of low grade albuminuria to MetS, using 4 current definitions and a MetS score. They studied 6650 consecutive, nondiabetic, hypertensive patients with normal microalbumin excretion. MetS was defined by Adult Treatment Panel III, American Heart Association, World Heart Organization, International Diabetes Federation criteria, and MetS Gruppo Italiano per lo Studio della Streptochinasi nell’Infarcto Miocardico (GISSI) score. Urine microalbumin concentration was measured after a 24‐hour urine collection by immunonephelometry. By all definitions, hypertensive patients with MetS had higher microalbumin levels. Significantly higher microalbumin levels were observed as the number of metabolic components rose. After adjustment for systolic blood pressure, the strength of this association was reduced to a nonsignificant level. Microalbumin levels, within normal range, are increased in patients with MetS, irrespective of the definition criteria.

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“…Increased AS is a common feature of metabolic syndrome (MetS) (Donley et al 2014; Scuteri et al 2004; Vyssoulis et al 2010) and is one of the driving forces behind the increased CV risk in patients with MetS. The mechanisms through which MetS increases AS are likely to be multi-factorial.…”

Section: Introductionmentioning

confidence: 99%

The effects of resistance exercise training on arterial stiffness in metabolic syndrome

et al. 2016

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Purpose Arterial stiffness is a strong independent risk factor for cardiovascular disease and is elevated in individuals with metabolic syndrome (MetS). Resistance training is a popular form of exercise that has beneficial effects on muscle mass, strength, balance and glucose control. However, it is unknown whether resistance exercise training (RT) can lower arterial stiffness in patients with MetS. Thus, the aim of this study was to examine whether a progressive RT program would improve arterial stiffness in MetS. Methods A total of 57 subjects (28 healthy sedentary subjects; 29 MetS) were evaluated for arterial structure and function, including pulse wave velocity (cfPWV: arterial stiffness), before and after an 8-week period of RT or continuation of sedentary lifestyle. Results We found that 8 weeks of progressive RT increased skeletal muscle strength in both Con and MetS, but did not change arterial stiffness in either MetS (cfPWV; Pre 7.9 ± 0.4 m/s vs. Post 7.7 ± 0.4 m/s) or healthy controls (cfPWV; Pre 6.9 ± 0.3 m/s vs. Post 7.0 ± 0.3 m/s). However, when cfPWV is considered as a continuous variable, high baseline measures of cfPWV tended to show a decrease in cfPWV following RT. Conclusion Eight weeks of progressive RT did not decrease the group mean values of arterial stiffness in individuals with MetS or healthy controls.

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Differential impact of metabolic syndrome on arterial stiffness and wave reflections: Focus on distinct definitions

Cited by 22 publications

References 44 publications

Maternal Arterial Stiffness in Women Who Subsequently Develop Pre-Eclampsia

Maternal Arterial Stiffness in Women Who Subsequently Develop Pre-Eclampsia

Urine Albumin Excretion, Within Normal Range, Reflects Increasing Prevalence of Metabolic Syndrome in Patients With Essential Hypertension

The effects of resistance exercise training on arterial stiffness in metabolic syndrome

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