Differential induction of oxidative impairments in brain regions of male mice following subchronic consumption of Khesari dhal (Lathyrus sativus) and detoxified Khesari dhal

Shinomol, George K.; Muralidhara, .

doi:10.1016/j.neuro.2007.03.002

Cited by 78 publications

(31 citation statements)

References 46 publications

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“…Sesamin has been reported to have many benefits and medicinal properties (Nakai et al, 2003;Bournival et al, 2012). In the present study, sesamin decreased the production of ROS and TBARS in kidney of fluoride-exposed carp in dose-dependent manner, which may be due to the powerful activities of scavenging antioxidant and free radical (Hemalatha et al, 2004;Shinomol and Muralidhara, 2007). These results indicated that treatment with sesamin could alleviate oxidative stress by reducing the concentration of ROS and TBARS in the kidney of fluoride-exposed carp.…”

Section: Sesamin Attenuated Antioxidant Enzyme Activities and Oxidatisupporting

confidence: 63%

Protective properties of sesamin against fluoride-induced oxidative stress and apoptosis in kidney of carp (Cyprinus carpio) via JNK signaling pathway

et al. 2015

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Section: Sesamin Attenuated Antioxidant Enzyme Activities and Oxidatisupporting

confidence: 63%

Protective properties of sesamin against fluoride-induced oxidative stress and apoptosis in kidney of carp (Cyprinus carpio) via JNK signaling pathway

et al. 2015

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“…It is possible that the neonatal brain lacks antioxidant reserves thus contributing to the differential susceptibility of various cell types during brain development (McQuillen and Ferriero 2004). Earlier we have studied the responsiveness of prepubertal mice brain to neurotoxicants (Shinomol and Muralidhara 2007). Based on these, it is speculated that preadolescence which involves considerable neural structuring and developmental transition of the brain might be a vulnerable period for neurotoxicity (Spear 2007).…”

Section: Discussionmentioning

confidence: 99%

Bacopa monnieri Extract Offsets Rotenone-Induced Cytotoxicity in Dopaminergic Cells and Oxidative Impairments in Mice Brain

et al. 2011

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Bacopa monnieri (BM), an ayurvedic medicinal herb is widely known for its memory enhancing ability and improvement of brain function. In this study, we tested the hypothesis that BM extract (BME) could offset neurotoxicant-induced oxidative dysfunctions in developing brain in a rotenone (ROT) mouse model. Pretreatment of dopaminergic (N27 cell lines) cells with BME exhibited significant cytoprotective effect as evidenced by the attenuation of ROT-induced oxidative stress and cell death. Further, the neuroprotective efficacy of BME was assessed in prepubertal mice administered ROT (i.p. 1.0 mg/kg b.w./day) for 7 days. BME treatment significantly offset ROT-induced oxidative damage in striatum (St) and other brain regions as evident by the normalized levels of oxidative markers (malondialdehyde, ROS levels, and hydroperoxides) and restoration of depleted GSH levels. Further, BME effectively normalized the protein carbonyl content in all brain regions suggesting its ability to prevent protein oxidation. Furthermore, BME treatment restored the activity levels of cytosolic antioxidant enzymes, neurotransmitter function, and dopamine levels in St. Based on our findings, we hypothesize that the neuroprotective effects of BM extract may be at least in part related to its ability to enhance reduced glutathione and antioxidant defenses in brain regions. It is suggested that BM may be effectively exploited as a prophylactic/therapeutic adjuvant for neurodegenerative disorders involving oxidative stress.

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“…In the present study, the fluorescent product DCF was measured using a spectrofluorimeter with excitation at 484 nm and emission at 530 nm as previously described (10). DCFH-DA in the absence of homogenates was used to determine background fluorescence.…”

Section: Methodsmentioning

confidence: 99%

Inhibition of RKIP aggravates thioacetamide‑induced acute liver failure in mice

et al. 2018

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Accumulating evidence has indicated that Raf kinase inhibitor protein (RKIP) is involved in several intracellular signaling pathways; its abnormal expression is associated with tumor progression and metastasis in several human neoplasms. However, the role of RKIP in acute liver injury has remained elusive. In the present study, acute liver failure was induced by thioacetamide in mice, and locostatin was used to interfere with RKIP expression. It was found that RKIP expression was significantly inhibited by locostatin. Down-regulation of RKIP expression resulted in severe liver injury and extensive release of alanine aminotransferase and aspartate aminotransferase. In addition, reduced RKIP expression significantly enhanced the levels of reactive oxygen species and the content of pro-inflammatory factors such as tumor necrosis factor-α as well as interleukin-6 and −1β, and decreased the levels of nuclear factor E2-related factor-2 and heme oxygenase-1. Furthermore, down-regulation of RKIP promoted the activation of the nuclear factor-κB and extracellular signal-regulated kinase signaling pathways. In conclusion, the present study indicates an inverse correlation between RKIP level and the degree of hepatic injury, that is, a decrease in RKIP expression may exacerbate acute liver failure.

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Differential induction of oxidative impairments in brain regions of male mice following subchronic consumption of Khesari dhal (Lathyrus sativus) and detoxified Khesari dhal

Cited by 78 publications

References 46 publications

Protective properties of sesamin against fluoride-induced oxidative stress and apoptosis in kidney of carp (Cyprinus carpio) via JNK signaling pathway

Protective properties of sesamin against fluoride-induced oxidative stress and apoptosis in kidney of carp (Cyprinus carpio) via JNK signaling pathway

Bacopa monnieri Extract Offsets Rotenone-Induced Cytotoxicity in Dopaminergic Cells and Oxidative Impairments in Mice Brain

Inhibition of RKIP aggravates thioacetamide‑induced acute liver failure in mice

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