Differential induction of P‐selectin expression on platelets by two cell separators during plateletpheresis and the effect of gender on the release of soluble P‐selectin

Abstract

This trial shows 1) that initial activation of platelets obtained with the MCS 3P is less than that of platelets obtained with the CS 3000 Plus; 2) that the increase in cP-selectin is a more sensitive marker for initial platelet activation than the expression of P-selectin on the surface; and 3) that the relative amount of cP-selectin is higher in women than in men given the same stimulus. Differences in platelet activation by various cell separators and the sex of the donor may contribute to variability of PC quality.

Evaluation of Different Preparation Procedures of Pathogen Reduction Technology(Mirasol®)-Treated Platelets Collected by Plateletpheresis

“…This resulted in an increased formation of platelet-leucocyte aggregation through the PSGL-1 receptor and subsequent clearance from the circulation [19][20][21]. Some investigators have suggested that soluble sCD62p is a more sensitive marker for platelet activation than CD62p surface expression [22]. We could not detect any difference in sCD62p levels due to PRT, but we found increased baseline levels and decreased activation capacity that was more prominent after PRT treatment.…”

Platelet indexes in relation to target organ damage in high-risk hypertensive patients

“…Increased MPV has been described (30), although not all studies confirm this (31). Raised MPV is also a risk factor for MI (32) and, in addition, is a marker of platelet activation (33)(34)(35). However, the link between other aspects of platelet physiology in hypertension and the presence of TOD has not been previously documented (i.e., raised MPV and MPM and lower MPG).…”

Extracorporeal Plateletpheresis Induces the Interaction of Activated Platelets with White Blood Cells

“…This process has also been observed in other studies. During cardiopulmonary bypass, hemodialysis, plasmapheresis and plateletpheresis, progressive platelet activation can be detected [21, 27, 28, 29, 30]. Several factors may explain this process.…”