Differential involvement of two cortical masticatory areas in modulation of the swallowing reflex in rats

Tsujimura, Takanori; Tsuji, Kojun; Ariyasinghe, Sajjiv; Fukuhara, Tsuyoshi; Yamada, Aki; Hayashi, Hirokazu; Nakamura, Yuki; Iwata, Koichi; Inoue, Makoto

doi:10.1016/j.neulet.2012.09.005

Cited by 32 publications

(20 citation statements)

References 26 publications

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“…Of 34 data, the threshold to evoke swallowing reflex was higher in 7 data of this study than that in the previous studies (Tsuji et al, 2015;Tsujimura et al, 2012). As described in other study (Mostafeezur et al, 2012), it was difficult to keep fixation of electrode to stimulate the SLN in the prone position in this study.…”

Section: Discussioncontrasting

confidence: 49%

“…Thus, the distinct projection patterns of the RPC and the RMC to the Vo, the Vi and the Vc may be related to the distinct effects on the onset latency of the first swallow. Tsujimura et al (2012) found that the Vc was not involved in the suppression of the swallowing reflex by noxious stimulation to the orofacial region. The suppressive effect of swallowing reflex by noxious stimulation was not affected after lesioning of the Vc.…”

Section: Discussionmentioning

confidence: 91%

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Suppression of the swallowing reflex by stimulation of the red nucleus

Satoh

Tsuji

Tsujimura

et al. 2015

Brain Research Bulletin

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 91%

Suppression of the swallowing reflex by stimulation of the red nucleus

Satoh

Tsuji

Tsujimura

et al. 2015

Brain Research Bulletin

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“…However, understanding specific aspects of neural control is still the realm of implanted electrodes, neural stimulation, and lesions, none of which are possible in human subjects. Stimulation studies can provide information on how specific nerves or CNS regions control or inhibit swallowing [13, 43, 46, 47]. Lesion studies can both mimic human injury, and specify the extent of functional involvement of different regions of the brain [17, 45].…”

Section: Animal Research and The Generation Of Performancementioning

confidence: 99%

Animal Models for Dysphagia Studies: What Have We Learnt So Far

et al. 2017

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Research using animal models has contributed significantly to realizing the goal of understanding dysfunction and improving the care of patients who suffer from dysphagia. But why should other researchers and the clinicians who see patients day in and day out care about this work? Results from studies of animal models have the potential to change and grow how we think about dysphagia research and practice in general, well beyond applying specific results to human studies. Animal research provides two key contributions to our understanding of dysphagia. The first is a more complete characterization of the physiology of both normal and pathological swallow than is possible in human subjects. The second is suggesting of specific, physiological, targets for development and testing of treatment interventions to improve dysphagia outcomes.

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“…This phenomenon suggests that the swallowing reflex is inhibited during chewing, because mechanical or chemical stimulation applied to the pharyngeal regions is known to immediately initiate the swallowing reflex[22]. Although we have previously shown that the swallowing reflex is inhibited during cortically evoked rhythmic jaw movements in anesthetized rats[23], whether this is also the case during natural mastication in humans is unclear.In the present study, we used PEStim to study the influence of peripheral inputs on the initiation of swallowing. We also employed the repetitive saliva swallowing test (which…”

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confidence: 99%