2010
DOI: 10.1016/j.vetimm.2010.06.009
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Differential levels of mRNA transcripts encoding immunologic mediators in mammary gland secretions from dairy cows with subclinical environmental Streptococci infections

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Cited by 20 publications
(13 citation statements)
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“…Considering the prominent role of neutrophils in the control of MG infections and the importance of the IL-17 immune axis in neutrophilic inflammation, we hypothesized that IL-17 and IL-17-producing cells could be among the effective components of the immune response to infection in the MG. Only a few circumstantial indications suggest that IL-17A is involved in mastitis, such as the presence of IL-17A in milk or IL-17A mRNA in milk cells or mammary tissue of mastitic cows (27,29,30). To gain a more direct evidence of the implication of IL-17A in the course of mastitis, we used a mouse model of E. coli mastitis with an E. coli strain that has been used extensively in experimentally induced MG infections in dairy cows (34)(35)(36) and mice (32,37,38).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Considering the prominent role of neutrophils in the control of MG infections and the importance of the IL-17 immune axis in neutrophilic inflammation, we hypothesized that IL-17 and IL-17-producing cells could be among the effective components of the immune response to infection in the MG. Only a few circumstantial indications suggest that IL-17A is involved in mastitis, such as the presence of IL-17A in milk or IL-17A mRNA in milk cells or mammary tissue of mastitic cows (27,29,30). To gain a more direct evidence of the implication of IL-17A in the course of mastitis, we used a mouse model of E. coli mastitis with an E. coli strain that has been used extensively in experimentally induced MG infections in dairy cows (34)(35)(36) and mice (32,37,38).…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, a few circumstantial evidences suggest that IL-17 has a bearing on mastitis. In a few published experiments, IL-17A mRNA has been detected in milk leukocytes and bovine mammary tissues infected by Staphylococcus aureus, Streptococcus uberis, or E. coli (27)(28)(29)(30). This suggests that MECs are exposed to IL-17A during intramammary infections.…”
mentioning
confidence: 95%
“…These cells respond by producing self-defense proteins and chemokines that attract and activate particularly neutrophils but also other leukocytes such as Th1 cells (Kolls and Khader, 2010). Transcripts of IL-17A were found in leukocytes attracted in milk by chronic S. aureus or streptococcal mastitis (Bruno et al, 2010;Tao and Mallard, 2007) or by immune-mediated mammary inflammation . Human and bovine MEC express the receptor for IL-17A and IL-17F, and bovine MEC respond to these two cytokines by producing antibacterial factors and chemokines (Bougarn et al, 2011).…”
Section: The Adaptive Cellular Immune Responsementioning
confidence: 99%
“…It has been shown recently that IL‐17 plays a pro‐inflammatory role in bovine mastitis (Tao & Mallard ; Bruno et al . ). Pro‐inflammatory cytokines can induce an antimicrobial response by epithelial cells and recruit neutrophils and dendritic cells to the infection site (reviewed by Kolls et al .…”
Section: List Of Eqtls Located On Bovine Chromosome 6 (Eqbta6) Signimentioning
confidence: 97%