Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women With Early and Advanced Endometriosis

Khan, Khaleque Newaz; Yamamoto, Kazuo; Fujishita, Akira; Muto, Hideki; Koshiba, Akemi; Kuroboshi, Haruo; Saito, Shigeru; Teramukai, Satoshi; Nakashima, Masahiro; Kitawaki, Jo

doi:10.1210/jc.2019-00350

Cited by 66 publications

(54 citation statements)

References 49 publications

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“…Most studies suggest the proportion of Tregs is significantly increased in peritoneal fluid from women with endometriosis compared with control women (157,158,161). One study reported that the number of Tregs was increased in the peritoneal fluid and decreased in the peripheral blood, and another study found the number of Tregs was higher in peritoneal fluid than in peripheral blood, both indicating that active translocation of Tregs occurs from circulation to the local peritoneal cavity (158,162). However, some studies failed to find any difference in the proportion of Tregs in patients with endometriosis when compared with women without endometriosis (159).…”

Section: Endometriosismentioning

confidence: 99%

Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases

2020

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Regulatory T cells (Tregs) are a specialized subset of T lymphocytes that function as suppressive immune cells and inhibit various elements of immune response in vitro and in vivo. While there are constraints on the number or function of Tregs which can be exploited to evoke an effective anti-tumor response, sufficient expansion of Tregs is essential for successful organ transplantation and for promoting tolerance of self and foreign antigens. The immune-suppressive property of Tregs equips this T lymphocyte subpopulation with a pivotal role in the establishment and maintenance of maternal tolerance to fetal alloantigens, which is necessary for successful pregnancy. Elevation in the level of pregnancy-related hormones including estrogen, progesterone and human chorionic gonadotropin promotes the recruitment and expansion of Tregs, directly implicating these cells in the regulation of fetal-maternal immune tolerance. Current studies have provided evidence that a defect in the number or function of Tregs contributes to the etiology of several reproductive diseases, such as recurrent spontaneous abortion, endometriosis, and pre-eclampsia. In this review, we provide insight into the underlying mechanism through which Tregs contribute to pregnancy-related immune tolerance and demonstrate the association between deficiencies in Tregs and the development of reproductive diseases.

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Section: Endometriosismentioning

confidence: 99%

Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases

2020

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“…Ectopic Foxp3 expression can phenotypically convert effector T cells to regulatory T cells [37]. A recent research found that endometriosis is related to changes in Treg and Th17 cells in the pelvis, leading to the survival and implantation of ectopic endometrial lesions [38]. The percentage of CD25 + FOXP3 + Treg cells is significantly increased in the peritoneal fluid of women with endometriosis [39].…”

Section: Discussionmentioning

confidence: 99%

Integrated Bioinformatics Analysis Reveals Function and Regulatory Network of miR-200b-3p in Endometriosis

Xie

et al. 2020

BioMed Research International

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Objective. MicroRNAs play vital roles in the development of endometriosis. It is reported that miR-200b-3p is downregulated in endometriosis, although its mechanisms in this disease remain still unclear. Therefore, the purpose of this study was to explore the function and potential regulatory network of miR-200b-3p in endometriosis through database analysis. Methods. The endometriosis gene expression profiles were downloaded from the GEO database to screen differentially expressed genes (DEGs). The predicted and validated target genes of miR-200b-3p were obtained from miRWalk and miRTarBase database. Then, a comparison was performed between miR-200b-3p target genes and DEGs. GO enrichment and KEGG pathway analysis of the target genes was performed using clusterProfiler package. STRING was used to predict the protein-protein interaction among the proteins encoded by the target genes. Then, TransmiR, LncBase, StarBase, PROMO, and AnimalTFDB were employed to identify interactive transcription factors and lncRNAs of miR-200b-3p. Results. miR-200b-3p was associated with the transcription factors DNMT1, EZH2, HNF1B, JUN, MYB, ZEB1, and ZEB2 during the pathogenesis of endometriosis. The downstream 110 target genes were involved in the biological processes of positive regulation of MAPK cascade, muscle cell proliferation, organ growth, vasculogenesis, and axon development. KEGG analysis revealed that the main pathways related to miR-200b-3p were microRNAs in cancer, PI3K-Akt signaling pathway, colorectal cancer, and tight junction. In addition, four lncRNAs such as MALAT1, NEAT1, SNHG22, and XIST interacted with miR-200b-3p and were associated with transcription factors FOXP3 and YY1. Conclusion. The predicted target genes and molecular regulatory network of miR-200b-3p in endometriosis not only revealed its biological function but also provided a valuable guideline for further research.

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“…However, OE is an inflammatory disease, which involves multiple organs, including the ovary and the uterus 12 . The peripheral subsets of immune cells are also considered suitable for evaluating the inflammatory status of OE 13 , 14 . Therefore, the number of peripheral CD56+ NKG2D+ NK cells can be used as a preoperative biomarker in OE patients.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, OE is often considered an inflammatory disease 12 . Notably, dysfunction of various lymphocyte subpopulations is pivotal for the pathogenesis of endometriosis 13 , 14 . For example, the imbalance of helper T cells (Th), B cells and Natural Killer (NK) cells, can lead to inflammation and further development of the ovarian lesions in OE 12 .…”

Section: Introductionmentioning

confidence: 99%

Circulating CD56+ NKG2D+ NK cells and postoperative fertility in ovarian endometrioma

Liu

2020

Sci Rep

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The current biomarkers for postoperative fertility assessment caused by ovarian endometrioma (OE) are insufficient. The present study hypothesized that the peripheral lymphocyte subpopulation can be used as a candidate biomarker of postoperative infertility in OE. The association of the number of circulating CD4/CD8 T, NK, and γδ T cells with postoperative fertility was assessed in 33 OE patients aged 20 ~ 40 years between June 2018 and January 2019. Concomitantly, 68 healthy female subjects were recruited. The changes in the baseline immune characteristics between the two groups were compared. The data demonstrated significant differences in the ratio of CD4/CD8 T cells and the number of CD56+ NKG2D+ NK cells and γδ T cells between OE patients and control subjects. The patients were followed-up till December 2019 and the number of CD56+ NKG2D+ NK cells in the cases was a significant predictor for postoperative fertility as determined by different COX regression models (crude HR = 0.220, 95% CI = 0.059–0.822; adjusted HR = 0.127, 95% CI = 0.024–0.675). A significant delay to successful pregnancy was noted in OE patients (median time, 173 vs. 99 days, log-rank P = 0.013). The present findings suggested that CD56+ NKG2D+ NK cells are a candidate biomarker of postoperative fertility in OE patients. Larger population studies are warranted.

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Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women With Early and Advanced Endometriosis

Cited by 66 publications

References 49 publications

Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases

Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases

Integrated Bioinformatics Analysis Reveals Function and Regulatory Network of miR-200b-3p in Endometriosis

Circulating CD56+ NKG2D+ NK cells and postoperative fertility in ovarian endometrioma

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