1998
DOI: 10.1016/s0981-9428(98)80081-8
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Differential localization and accumulation of the plant double stranded RNA-dependent protein kinase during virus infection

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Cited by 4 publications
(4 citation statements)
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“…The model further predicts that virus infection, at least in the absence of interferon treatment, may lead not only to an increase in the proportion of PKR that is phosphorylated but also to a reduction in the amount of PKR associated with ribosomes. Although this has not yet been tested in mammalian cells, both effects have recently been observed in a plant system infected with tobacco mosaic virus [41].…”
Section: Discussionmentioning
confidence: 99%
“…The model further predicts that virus infection, at least in the absence of interferon treatment, may lead not only to an increase in the proportion of PKR that is phosphorylated but also to a reduction in the amount of PKR associated with ribosomes. Although this has not yet been tested in mammalian cells, both effects have recently been observed in a plant system infected with tobacco mosaic virus [41].…”
Section: Discussionmentioning
confidence: 99%
“…(76) An analogue of PKR, pPKR, has been identified in plants. (77) Strikingly, pPKR protein levels increase upon virus infection and pPKR becomes phosphorylated in the same way as mammalian PKR. (77) (78,79) which is thought to be initiated by duplex RNAs formed during virus replication.…”
Section: Rna Degrading Enzymesmentioning
confidence: 99%
“…(77) Strikingly, pPKR protein levels increase upon virus infection and pPKR becomes phosphorylated in the same way as mammalian PKR. (77) (78,79) which is thought to be initiated by duplex RNAs formed during virus replication. Although both mammalian enzymes are active when expressed in plants, cell death does not occur when 2-5ase or RNaseL is expressed alone, which suggests that plants lack functional homologues of these enzymes.…”
Section: Rna Degrading Enzymesmentioning
confidence: 99%
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