2018
DOI: 10.1016/j.redox.2017.12.007
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Differential mitochondrial dinitrosyliron complex formation by nitrite and nitric oxide

Abstract: Nitrite represents an endocrine reserve of bioavailable nitric oxide (NO) that mediates a number of physiological responses including conferral of cytoprotection after ischemia/reperfusion (I/R). It has long been known that nitrite can react with non-heme iron to form dinitrosyliron complexes (DNIC). However, it remains unclear how quickly nitrite-dependent DNIC form in vivo, whether formation kinetics differ from that of NO-dependent DNIC, and whether DNIC play a role in the cytoprotective effects of nitrite.… Show more

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Cited by 17 publications
(14 citation statements)
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“…FeNOs, most likely heme-NO, are also formed upon treatment of liver homogenates with exogenous NO derived from ProliNONOate as demonstrated in Figure S9. It is however worth noting that Thomas et al have recently found that the rat liver has at least 8-fold higher concentrations of DNICs, measured by EPR, compared to NO detected via a ferricyanide-based chemiluminescence assay, which they specified as heme-nitrosyl [34]. Since we demonstrate that the ferricyanide assay can quantitatively release NO from both B- and MDNICs as well as heme-nitrosyl, and since EPR detects only MDNICs, one might expect their chemiluminescence concentrations to be at least equal to or higher than their EPR concentrations.…”
Section: Resultsmentioning
confidence: 99%
“…FeNOs, most likely heme-NO, are also formed upon treatment of liver homogenates with exogenous NO derived from ProliNONOate as demonstrated in Figure S9. It is however worth noting that Thomas et al have recently found that the rat liver has at least 8-fold higher concentrations of DNICs, measured by EPR, compared to NO detected via a ferricyanide-based chemiluminescence assay, which they specified as heme-nitrosyl [34]. Since we demonstrate that the ferricyanide assay can quantitatively release NO from both B- and MDNICs as well as heme-nitrosyl, and since EPR detects only MDNICs, one might expect their chemiluminescence concentrations to be at least equal to or higher than their EPR concentrations.…”
Section: Resultsmentioning
confidence: 99%
“…We have not investigated the source of the iron contribution to the FeNO species, which could be anything from deoxyhaemoglobin, other placental haeme proteins, or dinitrosyl iron complexes, which are poorly characterized in most tissues but have also been reported to form in tissue following nitrite reduction (Thomas et al . 2018). The latter two options represent species that are involved in many cellular signalling pathways such as gene expression and protein synthesis (Vasudevan et al .…”
Section: Discussionmentioning
confidence: 99%
“…[17][18][19][20] In particular, dinitrosyl complexes of iron have been proved to be biological intermediates formed during non-heme interaction with iron. 21 Due to the biomimetic action of molybdenum in nitrite reduction it is assumed that a NO-labeled complex of molybdenum could act as an intermediate in the natural nitrogen xation process. 22 Recently NO assisted Mo-mediated catalysis has proven helpful in hydrodesulfurization.…”
Section: Introductionmentioning
confidence: 99%