Differential modulation of cell recruitment and acute edema in a model of Polybia paulista venom-induced inflammation

Paula, Leandro Raphael N. de.; Santos, Wagner Ferreira dos; Malheiro, Adriana; Carlos, Daniela; Faccioli, Lúcia Helena

doi:10.1016/j.intimp.2005.08.002

Cited by 17 publications

(6 citation statements)

References 32 publications

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“…Envenomation is known to be accompanied by egress of neutrophils from the bone marrow into the blood, increasing the number of circulating neutrophils [ 22 , 41 ]. This phenomenon has also been observed in animal models, as injection of a variety of venoms to mice or rats resulted in an increase of neutrophil population and a massive recruitment to the inoculation site [ 24 , 41 , 43 ].…”

Section: Introductionmentioning

confidence: 84%

“…They include phospholipase A2 (PLA2) that cleaves plasma membrane phospholipids to release arachidonic acid; L-amino acid oxidase (LAAO) that catalyzes the deamination of L-amino acids to the corresponding a-ketoacids and production of hydrogen peroxide and ammonia; metalloproteinases that degrade membrane proteins; a family of peptides called disintegrins that bind to various cellular integrins; mastoparan that stimulates heterotrimeric G-proteins (Gi) and upregulate cellular functions; and parabutoporin thyat has antimicrobial properties and can modulate cell functions. These molecules are known to induce a variety of immune responses, including mastocyte degranulation, T cell activation, inflammasome activation in macrophages, and neutrophil activation [ 21 - 24 ]. In this review, after an overview of neutrophil ROS production, a key inflammatory function, we will summarize the most characterized effects of venom components on this neutrophil function and the known mechanism of action.…”

Section: Introductionmentioning

confidence: 99%

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Effects of venoms on neutrophil respiratory burst: a major inflammatory function

El-Benna

Hurtado-Nédelec

Gougerot‐Pocidalo

et al. 2021

J. Venom. Anim. Toxins incl. Trop. Dis

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Neutrophils play a pivotal role in innate immunity and in the inflammatory response. Neutrophils are very motile cells that are rapidly recruited to the inflammatory site as the body first line of defense. Their bactericidal activity is due to the release into the phagocytic vacuole, called phagosome, of several toxic molecules directed against microbes. Neutrophil stimulation induces release of this arsenal into the phagosome and induces the assembly at the membrane of subunits of the NAPDH oxidase, the enzyme responsible for the production of superoxide anion that gives rise to other reactive oxygen species (ROS), a process called respiratory burst. Altogether, they are responsible for the bactericidal activity of the neutrophils. Excessive activation of neutrophils can lead to extensive release of these toxic agents, inducing tissue injury and the inflammatory reaction. Envenomation, caused by different animal species (bees, wasps, scorpions, snakes etc.), is well known to induce a local and acute inflammatory reaction, characterized by recruitment and activation of leukocytes and the release of several inflammatory mediators, including prostaglandins and cytokines. Venoms contain several molecules such as enzymes (phospholipase A2, L-amino acid oxidase and proteases, among others) and peptides (disintegrins, mastoporan, parabutoporin etc.). These molecules are able to stimulate or inhibit ROS production by neutrophils. The present review article gives a general overview of the main neutrophil functions focusing on ROS production and summarizes how venoms and venom molecules can affect this function.

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Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Effects of venoms on neutrophil respiratory burst: a major inflammatory function

El-Benna

Hurtado-Nédelec

Gougerot‐Pocidalo

et al. 2021

J. Venom. Anim. Toxins incl. Trop. Dis

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show abstract

“…Histamine is responsible for local pain, as well as for the activation of complementary and endothelial cells, leukocyte recruitment and edema formation at the site of inflammation (Paula et al, 2006). Recent studies indicate that serotonin, as a neurotransmitter in the central nervous system, can modulate inflammatory response through its action on immune cells and mediators (Maleki et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Antioedematogenic effect of marrubiin obtained from Marrubium vulgare

Stulzer

Tagliari

Zampirolo

et al. 2006

Journal of Ethnopharmacology

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“…A dor e o inchaço foram os sintomas mais comuns nos casos de envenenamento por Hymenoptera, causado por componentes vasoativos do veneno (FITZGERALD e FLOOD, 2006). Normalmente ocorreu em indivíduos não alérgicos, o que corresponde à maioria da população (BOUSQUET et al, 1984;PAULA et al, 2006).…”

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Ocorrência De Acidentes Causados Por Ferroadas De Vespas Na Cidade De Ponta Grossa – Paraná

Oliveira¹,

Reche²,

Bittencourt³

2020

Publ. Biologicas

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A vespa Polybia paulista é comum no Brasil, especialmente no estado de São Paulo, podendo ser encontrada nos estados de Goiás, Mato Grosso, Paraná e Minas Gerais. Constrói seus ninhos em áreas urbanizadas, o que resulta numa maior probabilidade de ocorrer acidentes envolvendo essas espécies de artrópodes. O presente trabalho teve como objetivo realizar a coleta de dados sobre a incidência de acidentes causados por ferroadas de vespas, especificamente no município de Ponta Grossa, no estado do Paraná, conhecer os principais sintomas apresentados nos episódios de ferroadas e a porcentagem de pessoas que desenvolveram hipersensibilidade quando expostas ao veneno. Para isso, foi realizado um inquérito epidemiológico, por meio da aplicação de questionário em onze vilas da cidade, situadas próximas às áreas verdes. Os dados obtidos foram tabulados no Microsoft Office Excel e analisados com a utilização do programa EpiInfo, mediante análises exploratórias e estratificadas. Os resultados mostraram que dos 915 moradores entrevistados, 37,81% já haviam sido ferroados por vespas, dos quais somente 4,60% desenvolveram hipersensibilidade, mesmo com a presença de somente 22 (2,40%) ninhos da vespa Polybia paulista nas residências visitadas. Os locais do corpo mais atingidos por ferroadas foram as mãos (17,27%) e os braços (10,20%). De acordo com os resultados, pôde-se concluir que, nos bairros selecionados para o estudo, apesar da pequena quantidade de ninhos de vespa encontrados nas residências, detectou-se a ocorrência de número significativo de ferroadas, sendo os homens, os mais suscetíveis.

show abstract

Differential modulation of cell recruitment and acute edema in a model of Polybia paulista venom-induced inflammation

Cited by 17 publications

References 32 publications

Effects of venoms on neutrophil respiratory burst: a major inflammatory function

Effects of venoms on neutrophil respiratory burst: a major inflammatory function

Antioedematogenic effect of marrubiin obtained from Marrubium vulgare

Ocorrência De Acidentes Causados Por Ferroadas De Vespas Na Cidade De Ponta Grossa – Paraná

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