Differential pulse, square wave and adsorptive stripping voltammetric quantification of tianeptine in tablets

Gazy, Azza A.; Mahgoub, Hoda; Khamis, E.; Youssef, Rasha M.; Elsayed, M. Abdel-Hady

doi:10.1016/j.jpba.2006.02.039

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…-1.77 V in organic media [26]. On the other hand, the halide group in most organic compounds can be reduced only in alkaline media [27]. Accordingly, the mechanism of electrode reaction can be assigned to proton transfer reactions coupled to electron transfer to reduce azomethine group C=N in tetrazolyl group into saturated bond by consuming 2 electrons and 2 protons, as shown below: Variation of ionic strength at 0.02, 0.04, 0.06, 0.08 and 0.1 M supporting electrolyte BR at pH 7, has no distinct effect on the peak current and potential indicating the reduction is predominantly diffusion controlled.…”

Section: Resultsmentioning

confidence: 99%

Cathodic Stripping Voltammetric Determination of Losartan in Bulk and Pharmaceutical Products

Habib¹,

Weshahy²,

Toubar³

et al. 2007

Port. Electrochim. Acta

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Cathodic stripping voltammetric determination of losartan using hanging mercury drop electrode HMDE was described. The method was based on adsorptive accumulation of the species at HMDE and at pH 7, followed by alternating current AC sweep. The behavior of adsorptive stripping response was studied under various experimental conditions, e.g. type of supporting electrolyte, pH, accumulation time, scan rate and mode of sweep (direct current DC, differential pulse DP, square wave SW and AC). In Britton-Robinson buffer solution, pH 7, a quasi-reversible reaction took place. The reduction response was more sensitive than the oxidation one and it was linear over the concentration range of 0.16-1.2 µg/mL. The determination of the cited compound in oral dosages was achieved using the standard addition method. The average of determinations obtained by square wave adsorptive voltammetric method with its standard deviation was 100.1±3%.

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Section: Resultsmentioning

confidence: 99%

Cathodic Stripping Voltammetric Determination of Losartan in Bulk and Pharmaceutical Products

Habib¹,

Weshahy²,

Toubar³

et al. 2007

Port. Electrochim. Acta

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“…4.0-14.0 and 2.0-10.0 mg ml Ϫ1 for BPB, BCG, BTB and MO methods, respectively; this is good to that reported in another paper. 5) For the BPB method, the regression equation was Aϭ0.066Cϩ1.27ϫ10 Ϫ3 with rϭ0.9999. The limit of quantification (LOQ) was found to be 3.0 mg ml…”

Section: Effect Of Reaction Time and Temperaturementioning

confidence: 99%

“…2) Various methods have been reported in the literature for the analysis of Tia including spectrofluorimetry 3,4) and voltametry. 5) Reverse-phase high performance liquid chromatography/ fluorescence detection, 6) UV detection 7,8) and gas chromatography 9) are also reported for determination of Tia from human biological fluids.…”

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confidence: 99%

“…According to the literature research, [3][4][5][6][7][8][9] Tia has been ionpair associated with bromophenol blue (BPB), bromocresol green (BCG), bromothymol blue (BTB), methyl orange (MO) and determined by a spectrophotometric method for the first time. The proposed method for tianeptine determination has many advantages over other analytical methods due to its rapidity, lower cost and environmental safety.…”

mentioning

confidence: 99%

“…Recoveries were found to be between % 98.67 and 100.23, better than those reported in other paper. 5) A stability study of the colored ion-pair complex was developed and showed that yellow color was stable for 8 h at room temperature.…”

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confidence: 99%

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A New Spectrophotometric Method for the Determination of Tianeptine in Tablets Using Ion-Pair Reagents

Ulu

Aydoğmuş

2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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1635Tianeptine (Tia); 7- [(3-chloro-6,11]-dihydro-6-methyldibenzo [c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,Sdioxide ( Fig. 1) 1) is an antidepressant agent with a novel neurochemical profile. It increases serotonin (5-hydroxytryptamine; 5-HT) uptake in the brain (in contrast to most antidepressant agents) and reduces stress-induced atrophy of neuronal dendrites. Like the selective serotonin reuptake inhibitors (SSRIs) and in contrast with most tricyclic antidepressant agents, tianeptine does not appear to be associated with adverse cognitive, psychomotor, sleep, cardiovascular or bodyweight effects and has a low propensity for abuse. 2)Various methods have been reported in the literature for the analysis of Tia including spectrofluorimetry 3,4) and voltametry. 5)Reverse-phase high performance liquid chromatography/ fluorescence detection, 6) UV detection 7,8) and gas chromatography 9) are also reported for determination of Tia from human biological fluids.According to the literature research, 3-9) Tia has been ionpair associated with bromophenol blue (BPB), bromocresol green (BCG), bromothymol blue (BTB), methyl orange (MO) and determined by a spectrophotometric method for the first time. The proposed method for tianeptine determination has many advantages over other analytical methods due to its rapidity, lower cost and environmental safety. Unlike the gas chromatographic and HPLC procedures, the instrument is simple and is not costly. All statistical values (percentage recoveries, RSD, confidence limits of the slope and intercept, LOD and LOQ) were within the acceptable limits. Economically, all the analytical reagents are inexpensive and available in any analytical laboratory. The proposed method reports a new for the determination of Tia in pharmaceuticals.The present paper thus describes fast, simple, sensitive and validated spectrophotometric method for the determination of Tia. ExperimentalMaterials Tia and 12.5 mg tablets (Stablon ® ) were gifts from Servier (Istanbul, Turkey). BPB, BCG, BTB, and MO were purchased from Merck (Darmstadt, Germany). All chemicals and solvents used were of analytical and pharmaceutical grades. Water was always distilled.Solutions A stock solution of 1.0 mg ml Ϫ1 was prepared by dissolving 100 mg of Tia in 100 ml of water. Working standard solutions of Tia of 100 mg ml Ϫ1 were prepared by appropriate dilution of the stock solution with water and were stored 4°C. A 0.02% (w/v) of BPB, BCG, BTB and MO solutions was prepared by dissolving the accurately weighed amount of 20 mg in 100 ml of distilled water.Phthalate buffer was prepared by dissolving 2.042 g of potassium hydrogen phthalate in 50 ml of water. The pH was adjusted to 3.0 with 0.2 M HCl solution and the volume was made up to 200 ml with water.Apparatus A Shimadzu UV-160A UV-VIS spectrophotometer with 1 cm quartz cells was used. UV-Visible spectra were automatically obtained by Shimadzu UV-160A system software.Methods. General Procedure Into a series of 15 ml glass tubes 1 ml buffer solution of pH 3.0 and 1 ml ...

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Monographs in Electrochemistry

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Differential pulse, square wave and adsorptive stripping voltammetric quantification of tianeptine in tablets

Cited by 6 publications

References 9 publications

Cathodic Stripping Voltammetric Determination of Losartan in Bulk and Pharmaceutical Products

Cathodic Stripping Voltammetric Determination of Losartan in Bulk and Pharmaceutical Products

A New Spectrophotometric Method for the Determination of Tianeptine in Tablets Using Ion-Pair Reagents

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