Differential Pulse Voltammetric Determination of Uric Acid on Carbon‐Coated Iron Nanoparticle Modified Glassy Carbon Electrodes

Abstract

A carbon-coated iron nanoparticles (CIN, a new style fullerence related nanomaterial) modified glassy carbon electrode (CIN/GCE) has been developed for the determination of uric acid (UA). Electrochemical behaviors of UA on CIN/GCE were explored by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). It was found that the voltammetric response of UA on CIN/GC was enhanced dramatically because of the strong accumulation effect of CIN and the large working area of the CIN/GC electrode. The parameters including the pH of supporting electrolyte, accumulation potential and time, that govern the analytical performance of UA have been studied and optimized. The DPV signal of UA on CIN/GCE increased linearly with its concentration in the range from 5.0 Â 10 À7 to 2.0 Â 10 À5 M, with a detection limit of 1.5 Â 10 À7 M (S/N ¼ 3). The CIN/GCE was used for the determination of UA in samples with satisfactory results. The proposed CIN/GCE electrochemical sensing platform holds great promise for simple, rapid, and accurate detection of UA.

Preparation of selective and sensitive electrochemically treated pencil graphite electrodes for the determination of uric acid in urine and blood serum

“…Electrochemical studies of UA were mainly concentrated on the modified electrodes. In this manner, the modification of glassy carbon (GC) with covalently linked poly(vinyl alcohol) (Li and Lin, 2006), ribo nucleic acid (RNA) (Kang and Lin, 2006), poly(acrylic acid)-multiwalled carbon nanotube composite (Liu et al, 2007) and carbon coated iron nanoparticles (Wang et al, 2008) have been achieved and their electroanalytical performances were tested in the determination of UA.…”

Electrochemical Sensing of Uric Acid Using Glassy Carbon Modified with Multiwall Carbon Nanotubes Dispersed in Polyethylenimine

“…The presence of abnormal UA levels is a sign of gout, hyperuricemia or LeschNyhan syndrome. Therefore, simple, fast and sensitive methods are highly required for the quantification of this bioanalyte 1.…”

Electrochemical Behavior of Herbal Antitumor Drug Aloe‐Emodin at Carbon‐Coated Nickel Magnetic Nanoparticles Modified Glassy Carbon Electrode

“…All these slope values of E p versus pH in this paper were approximately close to the theoretical value of À57.6 mV pH À1 at 18 8C for a reversible proton-coupled single electron transfer. The slope of the linear dependences described by equation showed that the electron transfer was accompanied by the transfer of an equal number of protons [25]. In the range of pH 0.5À3.0, i p reached its maximum value at pH 1.0.…”

“…Magnetic carbon-coated nickel nanoparticles were prepared by the modified Alternating Current (AC) arc discharge method [24,25]. CNN were purified before use.…”

“…Thereby it can be quite useful in the research of the oxidation and reduction mechanism of biological molecules and the preparation of nanometer biological device. One recent development in this area is carbon-coated metal nanoparticles [24,25] with magnetic properties. Among these magnetic nanoparticles, carbon-coated nickel nanoparticles are the new magnetic material.…”