Differential pulse voltammetric determination of salbutamol sulfate in syrup pharmaceutical formulation using poly(4-amino-3-hydroxynaphthalene sulfonic acid) modified glassy carbon electrode

Abstract

A new method for determination of salbutamol sulfate has been developed using poly(4-amino-3-hydroxynaphthalene sulfonic acid/GCE. Cyclic voltammetric investigation of the electrochemical behavior of salbutamol sulfate at the polymer modified glassy carbon unveiled electrocatalytic activity of the modifier towards irreversible oxidation of salbutamol sulfate. Dependence of peak current predominantly on scan rate than on square root of scan rate, and peak potential shift with pH demonstrated that oxidation of salbutamol sulfate at the polymer modified electrode follows adsorption reaction kinetics with proton participation.Under optimized solution and differential pulse voltammetric parameters, the oxidative peak current showed linear dependence on salbutamol sulfate concentration in the range 0.2 to 8 μM with method detection limit (3s/m) and determination coefficient (R2) of 6.8 × 10−8 M and 0.99786, respectively. Low method detection limit, relatively wide linear range, and recovery results of spiked standard salbutamol sulfate in syrup samples in the range 96.7–98.9% validated the method for determination of salbutamol sulfate in pharmaceutical formulations.Differential pulse voltammetric analysis of salbutamol sulfate syrup formulation for its salbutamol sulfate content revealed 98.8 to 99.3% of the labeled value confirming the applicability of the developed method for determination of salbutamol sulfate in real samples.

An overview of recent developments of carbon-based sensors for the analysis of drug molecules

“…A rapid and effective electrochemical method for the determination of SAL was introduced by Abdol et al [137], using iron titanate nanopowder-modified CPE in phosphate nitrate solution having pH 7. Meareg et al [138] determined the electrochemical behavior of SAL at poly(4-amino-3-hydroxynaphthalene) sulfonic acid modified GCE in PBS of pH 7.0 and CV technique. The electrode reaction of SAL was observed to be ADS controlled.…”

Impact of nano-morphology, lattice defects and conductivity on the performance of graphene based electrochemical biosensors

“…Innovatively, DPV was used to sense salbutamol sulfate (SBS), a bronchodilator for asthma treatment banned by anti-doping agencies due to ergogenic action and side-effects including tachycardia and arrhythmia at high doses. The peak current response to SBS concentration covered a 0.2 to 8 µM linear range with a detection limit of 6.8 × 10 −8 M [21]. Chlorpromazine, used to treat depression, bipolar disorder and schizophrenia, can have serious overdose side-effects, including interpalpebral conjunctiva and cataracts.…”

Spectrophotometric Assay of Salbutamol Sulphate in Pharmaceutical Preparations by Coupling with Diazotized ρ-bromoaniline

“…Many methods have been reported for the determination of SBS, these include HPLC, Reverse phase high performance liquid chromatography (4,6,7,8) , achiral supercritical fluid chromatography (9), ion pair liquid chromatography (10),atomic absorption spectrophotometric (11), Differential pulse voltammetric (12), titrimetric method (13), continuous/stopped flow injection method (14), spectrophotometric methods (1, 15,16), first-order derivative spectroscopy (17) and Second Order Derivative method (18). The purpose of the present study is to develop a simple and sensitive method for the determination of salbutamol sulphate in pharmaceutical preparations using diazotization coupling reaction.…”