Differential pulse voltammetric indirect determination of aluminium in drinking waters, blood, urine, hair, and medicament samples using l-dopa under alkaline conditions

Abstract

The differential pulse voltammetric (DPV) indirect determination of aluminium using L-dopa under alkaline conditions on a glassy carbon working electrode was studied. The proposed method relies on the linear decrease of the DPV anodic peak current of L-dopa with increase in the concentration of aluminium added. Under the optimum experimental conditions (pH 8.5, 0.08 M NH4Cl-NH3.H2O buffer solution, and 4 x 10(-4) M L-dopa), the linear range is 2-18 x 10(-7) M AlIII. The detection limit is 7.6 x 10(-8) M and the relative standard deviation for 8 x 10(-7) M AlIII is 3.5% (n = 8). A number of foreign species were examined as potential interferents. The method was applied to the determination of aluminium in drinking waters, synthetic renal dialysate, sodium chloride injection, sucrafate, hydrothorax, blood, urine and hair samples. The physiological significance is discussed.

Application ofL-Dopa as an Electroactive Ligand for Indirect Determination of Aluminum in Biological Samples by Differential Pulse Voltammetry

“…Figure 1 shows that there is no current peak appearing in the potential range studied in the supporting electrolyte. The DPV anodic peak of L-dopa yields at þ436 mV, which is more negative than that at acidic pH [21] and more positive than that at basic pH [22,23] and also in agreement with that of the publication [25]. This reflects its known oxidation property at different pH.…”

“…Based on this knowledge, we have proposed L-dopa as a potential ligand and studied the differential pulse voltammetric indirect determination of aluminum in biological samples in acid pH (3.6-5.6) [21] and basic pH (7.6-9.2) [22,23]. Under the optimum experimental conditions, the corresponding detection limits were 3.5610 À7 M Al III (pH 4.8, 6610 À4 M L-dopa, 0.06 M NaAc-HAc) [21] and 7.6610 À8 M Al III (pH 8.5, 4610 À4 M L-dopa, 0.08 M NH 4 Cl-NH 3 Á H 2 O) [22,23], respectively. However, Kiss et al [24] has shown that the maximum content of 1:1, 1:2, and 1:3 aluminum noradrenaline complex present at pH are about 4.4, 6.4, and 8.5 respectively.…”

Direct Voltammetric Specific Recognition of Dopamine Using AlIII-DA Complexes at the Hanging Mercury Drop Electrode

“…Unlike the cases at solid electrodes, [30][31][32][33][34][35] the Al III -DA complex at HMDE can be directly observed on the LSV voltammogram. This success has practical meaning in pathologic research of neurodegenerative disorders in the future.…”

Highly Sensitive Aluminium(III) Ion Sensor Based on a Self-assembled Monolayer on a Gold Nanoparticles Modified Screen-printed Carbon Electrode

“…[11][12][13][14] An alternative way to conduct the electroanalysis of aluminium ion was through indirect electrochemical determination using electroactive aluminium chelators. [15][16][17][18][19] Chemically modified electrodes with the adsorption of dyes, such as pyrocatechol violet and alizarin, have been widely exploited for voltammetry determinations of aluminium.…”