Direct Voltammetric Specific Recognition of Dopamine Using AlIII-DA Complexes at the Hanging Mercury Drop Electrode

Zhang, Fuping; Zhang, Min; Cheng, Jiongjia; Li, Yang; Ji, Ming; Bi, Shuping

doi:10.2116/analsci.23.1325

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Dysfunction in DA and DA neurons could lead to neurological and psychiatric diseases, such as drug addiction, Parkinson's disease, schizophrenia, hyperprolactinemia and Tourette's syndrome (Belliotti et al, 1999;Zhang et al, 2007). After chronic exposure to several kinds of addictive substances, many molecular and cellular adaptive changes that occur in the DA mesocorticolimbic system may contribute to drug addiction.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Interventions on The Dopamine Motivation System Effectively Disturbed Cue-Induced Memory Reconsolidation Cocaine-Seeking Behavior for Rats

Li¹,

Li²,

Qu³

et al. 2021

Preprint

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Drug addiction is a disorder related to dysfunction in the neural reward memory circuits, and it is characterized by compulsive drug use despite terrible negative consequences. Memory reconsolidation, during which aroused memory is easy to strengthening, weakening or updating, plays an extremely important role in drug addiction. Effectively interfering with the drug memory reconsolidation process would be key in treating drug addiction, but this intervention currently remains impossible. The dopamine motivation system has been widely recognized as an important system for reward, but whether the dopamine motivation system participates in drug memory reconsolidation is unclear. We aimed to explore the role of the dopamine motivation system during the cue-induced cocaine memory reconsolidation process by examining the effect of different pharmacological interventions on the dopamine motivation system during cue-induced cocaine self-administration-related memory reconsolidation drug-seeking behavior. Using a combined behavioral and biological method, our results showed that high concentrations of SCH 23390 and raclopride, or VTA lesions, could effectively disturb subsequent cue-induced cocaine self-administration-related memory reconsolidation drug-seeking behavior in rats. However, low concentrations of SCH 23390 and raclopride could not block this behavior. In summary, only a high dose of dopamine D1 and D2 receptor antagonists, or VTA lesions, could effectively disturb subsequent cue-induced cocaine self-administration-related memory reconsolidation drug-seeking behavior. These findings indicated that pharmacological interventions in the dopamine motivation system could effectively disturb subsequent cue-induced drug memory reconsolidation. Thus, pharmacological interventions on the dopamine motivation system might have therapeutic potential for drug addiction.

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Section: Introductionmentioning

confidence: 99%

Pharmacological Interventions on The Dopamine Motivation System Effectively Disturbed Cue-Induced Memory Reconsolidation Cocaine-Seeking Behavior for Rats

Li¹,

Li²,

Qu³

et al. 2021

Preprint

View full text Add to dashboard Cite

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Anti-fouling In situ Deposited Antimony/Nafion Film Electrode for Electrochemical Stripping Analysis

Zhang,

Zheng,

Zhang

et al. 2013

International Journal of Electrochemical Science

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Electrochemical and Spectrometric Studies of Double-Strand Calf Thymus Gland DNA Denatured by Al(III) at Neutral pH

et al. 2009

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The interaction between double-strand calf thymus gland DNA (ds-DNA) and Al(III) was studied by using differential pulse voltammetry (DPV) at a hanging mercury drop electrode (HMDE), Raman spectrometry and circular dichroism (CD) spectra. It was shown that at neutral pH ds-DNA did not produce any cathodic peak at the HMDE in the potential window from -550 to -2000 mV vs. SCE. However, in the presence of Al(III), a cathodic peak was generated at about -1660 mV, which is ascribed to a reduction of adenine and cytosine residues of single denatured DNA (sd-DNA). It was concluded that ds-DNA was completely denatured to sd-DNA by Al(III) at a neutral pH. The apparent denaturing kinetic velocity constants of ds-DNA by Al(III) were derived from linear increases of the cathodic peak currents with time.3 ≥ 2 × 10 -26 , the precipitation of Al(OH)3 was observed and identified by the Raman spectrum, and inductively coupled plasma atomic emission spectrometry (ICP-AES). CD spectra showed that the B-type of structure conformations of ds-DNA and related sd-DNA did not change with the increment of Al(III) from 5.0 × 10 -7 to 1.0 10 -5 M, but the corresponding absorption strengths increased. The related physiological significances and possible applications of the observations were considered.

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Direct Voltammetric Specific Recognition of Dopamine Using AlIII-DA Complexes at the Hanging Mercury Drop Electrode

Cited by 3 publications

References 35 publications

Pharmacological Interventions on The Dopamine Motivation System Effectively Disturbed Cue-Induced Memory Reconsolidation Cocaine-Seeking Behavior for Rats

Pharmacological Interventions on The Dopamine Motivation System Effectively Disturbed Cue-Induced Memory Reconsolidation Cocaine-Seeking Behavior for Rats

Anti-fouling In situ Deposited Antimony/Nafion Film Electrode for Electrochemical Stripping Analysis

Electrochemical and Spectrometric Studies of Double-Strand Calf Thymus Gland DNA Denatured by Al(III) at Neutral pH

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