Differential regulation of membrane associated-growth hormone binding protein (MA-GHBP) and growth hormone receptor (GHR) expression by growth hormone (GH) in mouse liver

González, Lorena; Curto, Lucrecia María; Miquet, Johanna G.; Bartke, Andrzej; Turyn, Daniel; Sotelo, Ana I.

doi:10.1016/j.ghir.2006.12.002

Cited by 27 publications

(23 citation statements)

References 62 publications

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“…Whether this is specific to guinea pigs or common to all hystricomorph rodents is currently unknown. In addition to being present as membrane bound dimers, the GHR mRNA can undergo proteolytical cleavage in humans and rabbits, or alternative processing in rodents, to generate growth hormone binding protein (GHBP) that circulates in the blood (Edens and Talamantes 1998;González et al, 2007 ).…”

Section: Reconciling Ghr/igf1r Evolution With Life-history Traits In mentioning

confidence: 99%

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Molecular evolution of growth hormone and insulin-like growth factor 1 receptors in long-lived, small-bodied mammals

Davies

Tsagkogeorga

Bennett

et al. 2014

Gene

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Mammals typically display a robust positive relationship between lifespan and body size.Two groups that deviate markedly from this pattern are bats and the African mole-rats; with members of both groups being extremely long-lived given their body size, with the maximum documented lifespan for many species exceeding 20 years. A recent genomics study of the exceptionally long-lived Brandt's bat, Myotis brandtii (41 years), suggested its longevity and small body size may be at least partly attributed to key amino acid substitutions in the transmembrane domains of the receptors of growth hormone (GH) and insulin-like growth factor 1 (IGF1). However, whereas elevated longevity is likely to be common across all 19 bat families, the reported amino acid substitutions were only observed in two closely related bat families. To test the hypothesis that an altered GH/IGF1 axis relates to the longevity of African mole-rats and bats, we compared and analysed the homologous coding gene sequences in genomic and transcriptomic data from 26 bat species, five mole-rats and 38 outgroup species. Phylogenetic analyses of both genes recovered the majority of nodes in the currently accepted species tree with high support. Compared to other clades, such as primates and carnivores, the bats and rodents had longer branch lengths. The single 24 amino acid transmembrane domain of IGF1R was found to be more conserved across mammals compared to that of GHR.Within bats, considerable variation in the transmembrane domain of GHR was found, including a previously unreported deletion within the Emballonuridae. The transmembrane domains of rodents were found to be more conserved, with mole-rats lacking uniquely conserved amino acid substitutions. Molecular evolutionary analyses showed that both genes were under purifying selection in bats and mole-rats. Our findings suggest that while the previously documented mutations may confer some additional lifespan to Myotis bats, other, as yet unknown, genetic differences are likely to account for the long lifespans observed in many bat and mole-rat species.

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Section: Reconciling Ghr/igf1r Evolution With Life-history Traits In mentioning

confidence: 99%

“…In mice and other rodents, GHBP can also be present as a membrane-associated form (González et al, 2007 ). All three forms bind with GH with a high affinity and so are all likely to play interrelated roles in the regulation of this hormone.…”

Section: Reconciling Ghr/igf1r Evolution With Life-history Traits In mentioning

confidence: 99%

Molecular evolution of growth hormone and insulin-like growth factor 1 receptors in long-lived, small-bodied mammals

Davies

Tsagkogeorga

Bennett

et al. 2014

Gene

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“…Because the stimulation and inhibition of Ghrh and Ss1/Ss2 expression by UII respectively were observed 3 h after i.p. injection, the stimulation of Gh expression by UII was observed 6 and 12 h after injection, and the GH-induced GHR expression in the liver is a welldocumented phenomenon in mammals (Gonzalez et al 2007, Jiang et al 2007, we speculated that the stimulation of Ghr1 and Ghr2 expression by UII is the result of the increase in GH levels in the pituitary. GH is the principal regulator of IGF synthesis, and GH treatment in vivo and in vitro stimulates the mRNA expression of IGF1 and IGF2 in a variety of tissues, including those of fish and other vertebrates (Reindl & Sheridan 2012).…”

Section: Discussionmentioning

confidence: 94%

UII and UT in grouper: cloning and effects on the transcription of hormones related to growth control

Sun

Duan

et al. 2013

Journal of Endocrinology

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Urotensin II (UII) is a cyclic peptide that was originally extracted from the caudal neurosecretory system (CNSS) of fish. UII is well known to exhibit cardiovascular, ventilatory, and motor effects in vertebrates. Studies have reported that UII exerts mitogenic effects and can act as an autocrine/paracrine growth factor in mammals. However, similar information in fish is limited. In this study, the full-length cDNAs of UII and its receptor (UT) were cloned and characterized in the orange-spotted grouper. UII and UT were expressed ubiquitously in various tissues in grouper, and particularly high levels were observed in the CNSS, CNS, and ovary. A functional study showed that UT was coupled with intracellular Ca 2C mobilization in HEK293 cells. Studies carried out using i.p. injections of UII in grouper showed the following: i) in the hypothalamus, UII can significantly stimulate the mRNA expression of ghrh and simultaneously inhibit the mRNA expression of somatostatin 1 (ss1) and ss2 3 h after injection; ii) in the pituitary, UII also significantly induced the mRNA expression of gh 6 and 12 h after injection; and iii) in the liver, the mRNA expression levels of ghr1/ghr2 and igf1/igf2 were markedly increased 12 and 3 h after the i.p. injection of UII respectively. These results collectively indicate that the UII/UT system may play a role in the promotion of the growth of the orange-spotted grouper.

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“…Growth hormone can also affect the expression level of GHR. Growth hormone deficiency was associated with diminished body weight and GHR expression, while increased GH concentration led to increased GHR expression (González et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Expression profiles of growth hormone receptor and insulin-like growth factor I in cattle and yak tissues revealed by quantitative real-time PCR

et al. 2013

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The goals of this study were to compare the mRNA expression profiles of growth hormone recep tor (GHR) and insulin-like growth factor I (IGF-I) in various tissues of cattle and the semi-wild yak (Datong yak) and to find out whether the mRNA levels of the two genes are correlated. The mRNA levels of GHR and IGF-I in heart, lung, liver, spleen, pancreas, kidney, muscle, mammary gland and ovary of cattle and yak were investigated by using quantitative real-time po ly mer ase chain reaction (PCR). The experiments showed that the transcript levels of the two genes were sig nif i cant ly higher in liver (P<0.05) than in the other tissues for both species and that IGF-I levels varied more among tissues (P<0.01) than did GHR levels. The GHR tran script level in pancreas was higher in yak (P<0.05) than in cattle. There was no statistically sig nif i cant difference in IGF-I tran script levels among all the tissues of both bovine groups. Growth hormone receptor and IGF-I transcript levels were positively correlated in mammary gland (P<0.01), lung (P<0.05) and muscle (P<0.05) in yak, negatively correlated in cattle heart (P<0.05) and not correlated in the other tissues. The results indicate that the two genes are reg u lated differently in various tissues under normal physiological conditions in these two bovine species.

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Differential regulation of membrane associated-growth hormone binding protein (MA-GHBP) and growth hormone receptor (GHR) expression by growth hormone (GH) in mouse liver

Cited by 27 publications

References 62 publications

Molecular evolution of growth hormone and insulin-like growth factor 1 receptors in long-lived, small-bodied mammals

Molecular evolution of growth hormone and insulin-like growth factor 1 receptors in long-lived, small-bodied mammals

UII and UT in grouper: cloning and effects on the transcription of hormones related to growth control

Expression profiles of growth hormone receptor and insulin-like growth factor I in cattle and yak tissues revealed by quantitative real-time PCR

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