Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors

Wang, W.T.; Catto, James W.F.; Meuth, Mark

doi:10.1038/onc.2014.221

Cited by 18 publications

(20 citation statements)

References 159 publications

(180 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1, 2 SDAS is widely used as a measure of microstructural refinement, 3 but changes in SDAS are also accompanied by several other microstructural changes. [4][5][6][7] A decreasing SDAS generally increases the yield strength (YS), 4,5,7 the ultimate tensile strength (UTS) 1, 2, 5-9 and the ductility 1, 3, 5-7 of the material, but the trends may have variations due to concurrent changes in size and shape of eutectic Siparticles. [9][10][11] The plastic behaviour and fracture of cast aluminium alloys is furthermore highly affected by the characteristics [12][13][14] and damage 11,[15][16][17][18] of the Si-particles, where especially ductility 13 and strain hardening rate is increased with increased aspect ratio of the Si-particles.…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11] The plastic behaviour and fracture of cast aluminium alloys is furthermore highly affected by the characteristics [12][13][14] and damage 11,[15][16][17][18] of the Si-particles, where especially ductility 13 and strain hardening rate is increased with increased aspect ratio of the Si-particles. 15,16,19,20 Damage of the Si-particles consists of three stages: cracking or debonding, microcrack formation and growth, and local linkage of microcracks, 6,21 and both cracked 6,11,17,18 and debonded 18,22 particles may initiate global fracture. Particle fracture is caused by incompatibility stresses between particle and matrix, 18,22 and in general larger and longer particles are more likely to crack.…”

Section: Introductionmentioning

confidence: 99%

“…Particle fracture is caused by incompatibility stresses between particle and matrix, 18,22 and in general larger and longer particles are more likely to crack. 6,17 The probability of particle-cracking, ppc, can be described by Weibull statistics as 11…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Simulation of mechanical behaviour of cast aluminium components

Olofsson

2012

International Journal of Cast Metals Research

View full text Add to dashboard Cite

A literature review on methods to consider mechanical behaviour of cast aluminium alloys in finite element method (FEM) simulations of cast aluminium components has been performed. The mechanical behaviour is related to several microstructural parameters achieved during the casting process. Three different methods to consider these microstructural parameters are introduced. One method predicts the mechanical behaviour of the component using casting process simulation software. The other two methods implements numerical models for mechanical behaviour of cast aluminium into the FEM simulation. Applications of the methods are shown, including combinations with statistical methods and geometry optimisation methods. The methods are compared, and their different strengths and drawbacks are discussed.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Simulation of mechanical behaviour of cast aluminium components

Olofsson

2012

International Journal of Cast Metals Research

View full text Add to dashboard Cite

show abstract

“…A high local cooling rate gives a fine microstructure with a small secondary dendrite arm spacing (SDAS), while a lower cooling rate gives a coarser microstructure and a larger SDAS. 5,6) An increased cooling rate also refines the eutectic Si-particles 7) and strengthens the dendrites with Si. 8) The yield strength of ascast (not heat-treated) aluminium generally increases with higher cooling rate, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…decreasing SDAS. [8][9][10] Ultimate tensile strength and elongation to fracture also generally increases with higher cooling rates [5][6][7][8][9] but the trends may have variations due to concurrent changes in the morphology of the eutectic Si-particles. 11,12) Also the parameters of the Hollomon equation are found to be related to the microstructural refinement and generally decreases as the SDAS increases.…”

Section: Introductionmentioning

confidence: 99%

Closed Chain Simulations of a Cast Aluminium Component - Incorporating Casting Process Simulation and Local Material Characterization into Stress-strain Simulations

Olofsson¹,

Svensson²

2014

ISIJ Int.

View full text Add to dashboard Cite

The coupling between simulations of solidification, microstructure and local mechanical behaviour and simulation of stress-strain behaviour is studied by applying a recently developed simulation strategy to a high pressure die cast aluminium component. In the simulation strategy, named a closed chain of simulations for cast components, the mechanical behaviour throughout the component is determined locally by a casting process simulation. The entire casting process, including mould filling and solidification, is simulated to predict the formation of microstructure and residual stresses throughout the component, and material characterization models are applied to relate microstructural features to local elastic and plastic mechanical material behaviour. The local material behaviour is incorporated into a finite element method (FEM) stress-strain simulation of a realistic load case of the component in service.In the current contribution the influences of local variations in mechanical behaviour and residual stresses on the component behaviour are investigated. The simulation results for local microstructure and mechanical behaviour are compared to experimental results, and the predicted local mechanical behaviour is incorporated on an element level into the FEM simulation. The numerical effect of the variations in mechanical behaviour is quantified by comparing the results achieved using local behaviour and homogeneous behaviour. The influence of residual stresses predicted by the casting process simulation on the component behaviour is also studied.The casting process simulation is found to accurately predict the local variations in microstructure throughout the component, and the local variations in mechanical behaviour are well described. The numerical results show that casting process simulation and modelling of microstructure formation, material behaviour and residual stresses are important contributions to correctly predict the behaviour of a cast aluminium component in service. This motivates the use of the proposed simulation strategy, and show the importance of incorporating materials science and casting process simulations into structural analyses of cast components. It is discussed that integration of these areas, e.g. using the closed chain of simulations, is important in order to increase the accuracy of FEM simulations and the product development efficiency in the future.

show abstract

Physico-Mechanical and Electrical Properties of Aluminum-Based Composite Materials with Carbon Nanoparticles

Vorozhtsov¹,

Eskin²,

Vorozhtsov³

et al. 2014

Light Metals 2014

View full text Add to dashboard Cite

Nanocomposite materials with the matrix of an A356 alloy reinforced with 0.2 and 1 wt% of high-elastic nanodiamonds were produced by ultrasonic dispersion of nanoparticles in the melt followed by casting in a metallic mold. The structure as well as the physical and mechanical properties of the cast samples were examined using optical and scanning electron microscopy, hardness and tensile testing. It is shown that the hardness, Young's modulus and electrical resistivity increase with introduction of nanodiamond particles.

show abstract

Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors

Cited by 18 publications

References 159 publications

Simulation of mechanical behaviour of cast aluminium components

Simulation of mechanical behaviour of cast aluminium components

Closed Chain Simulations of a Cast Aluminium Component - Incorporating Casting Process Simulation and Local Material Characterization into Stress-strain Simulations

Physico-Mechanical and Electrical Properties of Aluminum-Based Composite Materials with Carbon Nanoparticles

Contact Info

Product

Resources

About