Differential response of two somatolactin genes to zinc or estrogen in pituitary of Cyprinus carpio

Valenzuela, G; Perez, Andrea I. Loaiza; Navarro, Mauricio A.; Romero, Alex; Figueroa, Jaime; Kausel, Gudrun

doi:10.1016/j.ygcen.2014.09.015

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…In a parallel experiment, a significant increase of vg expression in response to 17b-estradiol was not accompanied by changes in mt expression. This leads to the suggestion that specific stimuli elicit specific physiological responses, activating either the heavy metal response pathway or the estrogen receptor pathway, thereby validating the use of mt and vg as specific biomarker genes (Valenzuela et al 2015). Due to the fact that vg expression did not increase significantly in male fish exposed to STP-effluents at D compared to control, but was at least higher compared to fish exposed downstream of the effluents, estrogenic contaminants cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

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Aquatic pollution from anthropogenic discharges modulates gene expression in liver of rainbow trout (Oncorhynchus mykiss)

Nieto

Leal

Schwaiger³

et al. 2021

Austral j. vet. sci.

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With the aim to characterise the biological impact of anthropogenic discharge in a river, gene expression in fish was evaluated as a biomarker for mixture effects of potential toxic compounds in the aquatic environment. Adult male rainbow trout (Oncorhynchus mykiss) were used as monitoring organisms. Within the German experimental set up, trout were exposed actively for 28 days in biologically purified sewage as well as in river water up-and downstream of the sewage treatment plant (STP) effluent. In a different approach, wild trout were captured in southern Chile near anthropogenic discharges. Fish were taken from river Maullin receiving sewage from a settlement and from river Pescado influenced by effluents from a fish farm. In vivo effects were assessed by RT-qPCR analyses of biomarker gene expression, vitellogenin (vg), metallothionein (mt) and cytochrome 1A (cyp1A) in liver samples with primers amplifying specific sequences previously confirmed by cloning and sequencing. The modulation of expression of marker genes involved in metal stress, reproduction and detoxifying systems in the liver of male rainbow trout revealed organismal response to anthropogenic contamination in two different study areas, such as Chile and Germany, thereby indicating a potential risk on the aquatic ecosystems.

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Section: Discussionmentioning

confidence: 99%

“…Males also produce VG under the influence of estrogenic compounds (Mommsen and Walsh 1988). An overexpression of VG has been observed in male carp as a consequence of exposure to estrogenic compounds (Valenzuela et al 2015) and is considered as part of a feminisation process in male fish (Hamilton et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Aquatic pollution from anthropogenic discharges modulates gene expression in liver of rainbow trout (Oncorhynchus mykiss)

Nieto

Leal

Schwaiger³

et al. 2021

Austral j. vet. sci.

View full text Add to dashboard Cite

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“…Since fish presented reduced growth, the higher expression levels of igf-1 and its receptor in skeletal muscle might be related to a dysregulation in their expression originated by the early exposition to As III . In common carp, a decreased expression of gh mRNA was detected in the pituitary in response to Zn ( 290 ). In rainbow trout, a decreased expression of gh , igf-1 , and igf- 2 was detected in an exposure time-dependent response to Zn and Co ( 291 ).…”

Section: Effect Of Different Pollutants On the Fish Endocrine Network...mentioning

confidence: 99%

The effect of environmental stressors on growth in fish and its endocrine control

Canosa

Bertucci

2023

Front. Endocrinol.

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Fish body growth is a trait of major importance for individual survival and reproduction. It has implications in population, ecology, and evolution. Somatic growth is controlled by the GH/IGF endocrine axis and is influenced by nutrition, feeding, and reproductive-regulating hormones as well as abiotic factors such as temperature, oxygen levels, and salinity. Global climate change and anthropogenic pollutants will modify environmental conditions affecting directly or indirectly fish growth performance. In the present review, we offer an overview of somatic growth and its interplay with the feeding regulatory axis and summarize the effects of global warming and the main anthropogenic pollutants on these endocrine axes.

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Characterization and expression analyses of somatolactin-α and -β genes in rare minnows (Gobiocypris rarus) following waterborne cadmium exposure

Liu

Xie

Wang

et al. 2018

Fish Physiol Biochem

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Using reverse transcription-polymerase chain reaction (RT-PCR) and RACE (rapid amplification of cDNA ends), somatolactin-α (rmSLα) and -β (rmSLβ) were identified from the pituitary gland of rare minnows (Gobiocypris rarus). The full-length cDNAs of these two genes were 1288 and 801 bp, encoding prepeptides of 250 and 228 amino acids residues, respectively. rmSLβ can be detected in the brain (including the pituitary), ovary, testis, and gill, while rmSLα was mainly expressed in the brain. On the other hand, rmSLα was expressed in all the fetal developmental stages; however, rmSLβ can just be detected in the stages since from 14 h post-fertilization (hpf). After exposure to acute waterborne cadmium (Cd), rmSLα was distinctly upregulated in juvenile rare minnows at all detected time points, from 24 to 96 h and 10 days, while rmSLβ was significantly altered only in 96 h or 10-day treatment groups. As for adults, acute Cd exposure caused alterations of both rmSLα and rmSLβ in the brain (containing the pituitary) at the 24 h; subchronic waterborne Cd treatment led to upregulation of rmSLα, while decrease of mSLβ in the brain. Alteration of rmSL transcripts following waterborne Cd exposure further confirmed the endocrine disruption of this heavy metal. Besides, exposure to as low as 5 μg/L Cd caused alteration of rmSLα, which suggested that rmSLα might be a potential biomarker for risk assessment of aquatic Cd.

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Differential response of two somatolactin genes to zinc or estrogen in pituitary of Cyprinus carpio

Cited by 4 publications

References 39 publications

Aquatic pollution from anthropogenic discharges modulates gene expression in liver of rainbow trout (Oncorhynchus mykiss)

Aquatic pollution from anthropogenic discharges modulates gene expression in liver of rainbow trout (Oncorhynchus mykiss)

The effect of environmental stressors on growth in fish and its endocrine control

Characterization and expression analyses of somatolactin-α and -β genes in rare minnows (Gobiocypris rarus) following waterborne cadmium exposure

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