Differential response to resistance training in CHF according to ACE genotype

Williams, Andrew D.; Anderson, Mitchell; Selig, Steve E; Carey, Michael; Febbraio, Mark A.; Hayes, Alan; Toia, Deidre; Harrap, Stephen B; Hare, David

doi:10.1016/j.ijcard.2010.02.012

Cited by 8 publications

(5 citation statements)

References 31 publications

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“…It is acknowledged that a limitation of this study is sample size and that more participants should be investigated or added to the dataset for firm conclusions to be drawn. However, it is worth noting that previous studies such as de Souza et al (2013), Folland et al (2000, Santana et al (2011), andWilliams et al (2011) have found positive ACE results/associations with sample sizes smaller than in the present study (range n = 27 to n = 41).…”

Section: Discussioncontrasting

confidence: 65%

The influence of angiotensin converting enzyme and bradykinin receptor B₂ gene variants on voluntary fluid intake and fluid balance in healthy men during moderate-intensity exercise in the heat

Yau

Moss

James

et al. 2015

Appl. Physiol. Nutr. Metab.

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Angiotensin converting enzyme (ACE) and bradykinin receptor B2 (B2R) genetic variation may affect thirst because of effects on angiotensin II production and bradykinin activity, respectively. To examine this, 45 healthy Caucasian men completed 60 min of cycle exercise at 62% ± 5% peak oxygen uptake in a room heated to 30.5 ± 0.3 °C with ad libitum fluid intake. Blood samples were collected pre-, mid-, and immediately post-cycle. Fluid intake, body mass loss (BML), sweat loss (determined via changes in body mass and fluid intake), and thirst sensation were recorded. All participants were genotyped for the ACE insert fragment (I) and the B2R insert sequence (P). Participants were homozygous for the wild-type allele (WW or MM), heterozygous (WI or MP) or homozygous for the insert (II or PP). No differences between genotype groups were found in mean (±SD) voluntary fluid intake (WW: 613 ± 388, WI: 753 ± 385, II: 862 ± 421 mL, p = 0.31; MM: 599 ± 322, MP: 745 ± 374, PP: 870 ± 459 mL, p = 0.20), percentage BML or any other fluid balance variables for both the ACE and B2R genes, respectively. Mean thirst perception in the B2R PP group, however, was higher (p < 0.05) than both MM and MP at 30, 45, and 60 min. In conclusion, the results of this study suggest that voluntary fluid intake and fluid balance in healthy men performing 60 min of moderate-intensity exercise in the heat are not predominantly influenced by ACE or B2R genetic variation.

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Section: Discussioncontrasting

confidence: 65%

The influence of angiotensin converting enzyme and bradykinin receptor B₂ gene variants on voluntary fluid intake and fluid balance in healthy men during moderate-intensity exercise in the heat

Yau

Moss

James

et al. 2015

Appl. Physiol. Nutr. Metab.

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“…A χ 2 test was used to determine whether the observed genotype frequency was in Hardy-Weinberg equilibrium (expected frequency of alleles: (p²+2pq+q²=1), where p is the more common allele and q is the less common allele). 26 The reliability of the 10RM load assessments was determined with the ICC and the reliability was categorized as "excellent" for ICC values in the range of 0.8-1.0 and "good" for 0.6-0.8, whereas values <0.6 were "poor." 27 A one-way analysis of variance (ANOVA) was used to test the differences in age, body composition, exercise load (10RM) and hemodynamic variables before the first exercise set among the ACE I/D gene polymorphisms (i.e.…”

Section: Discussionmentioning

confidence: 99%

The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises

Freire

Machado

Ribeiro

et al. 2014

J Renin Angiotensin Aldosterone Syst

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Hypothesis/introduction: The association of ACE I/D polymorphism and hemodynamic response to exercise have been limited to primarily aerobic exercises. We hypothesized that D allele carriers would show greater hemodynamic response to resistance exercise, as has been observed with aerobic. This study aimed to investigate the association of ACE I/D polymorphism and hemodynamic (blood pressure (BP), heart rate (HR) and rate-pressure product (RPP)) response to resistance exercise in young healthy subjects. Materials and methods: ACE I/D polymorphisms were studied by PCR analysis from 75 healthy men. Subjects completed a resistance exercise session of three sets of 10 knee extension repetitions with loads of 50, 75 and 100% of 10RM and two-minute rest intervals. Hemodynamic measures were recorded before and immediately after each set. Analysis of variance was used to identify significant differences among ACE genotypes. Results: ACE I/D polymorphism is associated with hemodynamic response to resistance exercise, as healthy subjects with ACE D allele were prone to higher responses. In addition, this phenotypic difference seems to be a load-dependent trend. Conclusion: ACE DD carriers exhibit greater heart work during resistance exercise. Future studies should focus on the influence of resistance training period with different workloads on the hemodynamic response in healthy individuals with different ACE genotypes.

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“…Concerning the 287bp insertion/deletion (I/D) polymorphism, a body of evidence associates the D allele to a lower aerobic fitness 1,2 with some studies associating it to power-demanding exercises 3,4 . In contrast, the I allele has been related to an improved endothelium-dependent vasodilation 5 , higher percentage of the most efficient type I muscle fibers 6 , thus suggesting that type II carriers would present higher VO 2max .…”

Section: Introductionmentioning

confidence: 99%

A influência do genótipo da ECA sobre a aptidão cardiovascular de jovens do sexo masculino moderadamente ativos

Almeida¹,

Boullosa²,

Pardono³

et al. 2012

Arq. Bras. Cardiol.

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Differential response to resistance training in CHF according to ACE genotype

Cited by 8 publications

References 31 publications

The influence of angiotensin converting enzyme and bradykinin receptor B₂ gene variants on voluntary fluid intake and fluid balance in healthy men during moderate-intensity exercise in the heat

The influence of angiotensin converting enzyme and bradykinin receptor B₂ gene variants on voluntary fluid intake and fluid balance in healthy men during moderate-intensity exercise in the heat

The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises

A influência do genótipo da ECA sobre a aptidão cardiovascular de jovens do sexo masculino moderadamente ativos

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Differential response to resistance training in CHF according to ACE genotype

Cited by 8 publications

References 31 publications

The influence of angiotensin converting enzyme and bradykinin receptor B2 gene variants on voluntary fluid intake and fluid balance in healthy men during moderate-intensity exercise in the heat

The influence of angiotensin converting enzyme and bradykinin receptor B2 gene variants on voluntary fluid intake and fluid balance in healthy men during moderate-intensity exercise in the heat

The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises

A influência do genótipo da ECA sobre a aptidão cardiovascular de jovens do sexo masculino moderadamente ativos

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Product

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The influence of angiotensin converting enzyme and bradykinin receptor B₂ gene variants on voluntary fluid intake and fluid balance in healthy men during moderate-intensity exercise in the heat

The influence of angiotensin converting enzyme and bradykinin receptor B₂ gene variants on voluntary fluid intake and fluid balance in healthy men during moderate-intensity exercise in the heat