Differential roles of ERK, JNK and p38 MAPK in pain-related spatial and temporal enhancement of synaptic responses in the hippocampal formation of rats: Multi-electrode array recordings

Liu, Ming-Gang; Wang, Ruirui; Chen, Xuefeng; Zhang, Fu-Kang; Cui, Xiuyu; Chen, Jun

doi:10.1016/j.brainres.2011.01.076

Cited by 53 publications

(41 citation statements)

References 73 publications

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“…6). This augmented LTP is dependent on the peripherally painful state and activation of mGluR5, ERK and JNK, but with negative modulation by mGluR1 and p38 MAPK in the EC-DG and EC-CA1 pathways [32,33] . Overall, using MEAs to record LTP has the following advantages: (1) it can reveal the spatial proper-ties of LTP distribution in different microcircuits or layers within a single slice; (2) it provides a much longer period of LTP recording than conventional electrophysiological techniques; and (3) it maps LTP induction within a wider scope and reveals its alteration under pathological conditions.…”

Section: Examples Of Ltp Recording Using Mea Techniquesmentioning

confidence: 95%

“…5) [31] . In addition, mGluR1 and p38 MAPK appear to be involved in the tonic inhibition of EC-DG and EC-CA1 synaptic enhancement, while ERK may mediate persistent painassociated spatial extension [32,33] . Moreover, the enhancing effects on the spatial organization of network synaptic con- physiology and in vitro patch clamp recording), and further highlight the superiority of multisite recording using MEA techniques.…”

Section: Experimental Setupsmentioning

confidence: 99%

“…It is well-suited for studying synaptic plasticity [21,[31][32][33] , single unit activity [49,50] , rhythmic activity [17,45,51] , and pharmacological drug testing [23,46,52] . Furthermore, powerful analytical softwares (e.g.…”

Section: Examples Of Ltd Recording Using Meas Besidesmentioning

confidence: 99%

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Use of multi-electrode array recordings in studies of network synaptic plasticity in both time and space

Liu

Chen

et al. 2012

Neurosci. Bull.

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Simultaneous multisite recording using multi-electrode arrays (MEAs) in cultured and acutely-dissociated brain slices and other tissues is an emerging technique in the field of network electrophysiology. Over the past 40 years, great efforts have been made by both scientists and commercial concerns, to advance this technique. The MEA technique has been widely applied to many regions of the brain, retina, heart and smooth muscle in various studies at the network level.The present review starts from the development of MEA techniques and their uses in brain preparations, and then specifically concentrates on the use of MEA recordings in studies of synaptic plasticity at the network level in both the temporal and spatial domains. Because the MEA technique helps bridge the gap between single-cell recordings and behavioral assays, its wide application will undoubtedly shed light on the mechanisms underlying brain functions and dysfunctions at the network level that remained largely unknown due to the technical difficulties before it matured.

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Section: Examples Of Ltp Recording Using Mea Techniquesmentioning

confidence: 95%

Section: Experimental Setupsmentioning

confidence: 99%

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Use of multi-electrode array recordings in studies of network synaptic plasticity in both time and space

Liu

Chen

et al. 2012

Neurosci. Bull.

Self Cite

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“…The extracellular signal-regulated protein kinase 1/2 (ERK1/2) and another type of mitogen-activated protein kinase, p38 MAPK, have been postulated to be involved in TRP-associated responses to noxious temperatures in sensory neurons (13,27,28). The impact of kinases such as p38 and ERK1/2 on the regulation of TRPA1 synthesis and/or activity upon cold and heat needs to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Differential Expression and Functionality of TRPA1 Protein Genetic Variants in Conditions of Thermal Stimulation

May

Baastrup

Nientit

et al. 2012

Journal of Biological Chemistry

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Background: TRPA1 is a calcium channel expressed in polymodal nociceptors sensitive to noxious cold temperature. Results: Cold triggered calcium influx in cells expressing wild type TRPA1, but not variant Lys-179. Conclusion:The impaired cold sensitivity of variant TRPA1 protein might result in altered sensory responses of nociceptors. Significance: The understanding of molecular basis of sensory phenotypes is critical for adequate therapy of pain patients.

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“…[9][10][11][12] Researchers have made a lot of progresses and achievements in the studies of cardiac electrical characteristics by using MEA. Most of the methods, however, needed to culture cardiac cells 13,14 and to use outside electrical stimulation.…”

Section: Introductionmentioning

confidence: 99%

Effects of Acute Hyperglycemia and Insulin Intervention on the Spontaneous Field Potential of Sinoatrial Node Tissue by Using Microelectrode Arrays

Feng

Cao

Zhang

2015

J. Mech. Med. Biol.

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Traditional studies on the relationship between hyperglycemia and heart diseases generally focused on the impact of chronic and long-term effect of diabetes on cardiac functions. Most of the methods were culturing myocardial cells and giving outside stimulations. However, recent studies show that acute hyperglycemia might play a significant role in spontaneous cardiac electrophysiology. In this research we applied microelectrode arrays (MEA) to record the spontaneous sinoatrial node field potentials of C57/BL6J mice and analyzed the effects of different glucose concentrations in time domain and frequency domain by using statistical method, vector maps and fast Fourier transform (FFT). Meanwhile, we studied the effects of insulin interference in the experimental process. When the concentration of the glucose solution was greater than 40 mmol/L, the spontaneous sinoatrial node field potential changed markedly. In the time domain, the amplitude decreased rapidly and the conductive characteristics were disordered. In the frequency domain, the two spectrum peaks decreased rapidly. These changes were irreversible. However, insulin preconditioning could inhibit the impact of high glucose.

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Differential roles of ERK, JNK and p38 MAPK in pain-related spatial and temporal enhancement of synaptic responses in the hippocampal formation of rats: Multi-electrode array recordings

Cited by 53 publications

References 73 publications

Use of multi-electrode array recordings in studies of network synaptic plasticity in both time and space

Use of multi-electrode array recordings in studies of network synaptic plasticity in both time and space

Differential Expression and Functionality of TRPA1 Protein Genetic Variants in Conditions of Thermal Stimulation

Effects of Acute Hyperglycemia and Insulin Intervention on the Spontaneous Field Potential of Sinoatrial Node Tissue by Using Microelectrode Arrays

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