Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats

Wang, Xueqin; Zhong, Xiaolin; Li, Zhibin; Wang, Hongtao; Zhang, Juan; Li, Fangfang; Zhang, Jianyi; Dai, Renke; Zhou, Xin‐Fu; Li, Chang-Qi; Li, Zhiyuan; Bi, Fangfang

doi:10.1186/s12868-015-0150-x

Cited by 40 publications

(35 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there are conflicting reports on the effects of pain on natural food rewards, including sucrose preference, with some studies demonstrating decreased sucrose consumption [1; 48; 50; 81; 93; 99] while others show no change [66; 76; 94]. A study by Schwartz and colleagues used mice with sciatic nerve injury-induced neuropathic pain or CFA-induced inflammation and demonstrated that even though injured animals showed no deficits in sucrose preference, they displayed decreased motivation for food reward in a progressive ratio operant responding task [76].…”

Section: Impact Of Chronic Pain On Motivational and Hedonic Componentmentioning

confidence: 99%

Reward, motivation, and emotion of pain and its relief

Porreca

Navratilova

2017

Pain

133

View full text Add to dashboard Cite

The experience of pain depends on interpretation of context and past experience that guide the choice of an immediate behavioral response and influence future decisions of actions to avoid harm. The aversive qualities of pain underlie its physiological role in learning and motivation. In this review, we highlight findings from human and animal investigations that suggest that both pain, and the relief of pain, are complex emotions that are comprised of feelings and their motivational consequences. Relief of aversive states, including pain, is rewarding. How relief of pain aversiveness occurs is not well understood. Termination of aversive states can directly provide relief as well as reinforce behaviors that result in avoidance of pain. Emerging preclinical data also suggests that relief may elicit a positive hedonic value that results from activation of neural cortical and mesolimbic brain circuits that may also motivate behavior. Brain circuits mediating the reward of pain relief, as well as relief-induced motivation are significantly impacted as pain becomes chronic. In chronic pain states, the negative motivational value of nociception may be increased while the value of the reward of pain relief may decrease. As a consequence, the impact of pain on these ancient, and conserved brain limbic circuits suggest a path forward for discovery of new pain therapies.

show abstract

Section: Impact Of Chronic Pain On Motivational and Hedonic Componentmentioning

confidence: 99%

Reward, motivation, and emotion of pain and its relief

Porreca

Navratilova

2017

Pain

133

View full text Add to dashboard Cite

show abstract

“…However, pain-induced alterations in responses to natural food rewards, including sucrose preference, have been variable, with some studies reporting decreased sucrose consumption [1; 23; 24; 42; 46; 49] or no change [39; 48]. Although no deficits were observed in sucrose preference in mice with either sciatic nerve injury-induced neuropathic pain or CFA-induced inflammation, decreased motivation for food reward using operant responding has been observed [39].…”

Section: Introductionmentioning

confidence: 99%

Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain

Okun

McKinzie

Witkin

et al. 2016

Pain

View full text Add to dashboard Cite

Rewards influence responses to acute painful stimuli, but the relationship of chronic pain to hedonic or motivational aspects of reward is not well understood. Here, we independently evaluated hedonic qualities of sweet or bitter tastants as well as motivation to seek food reward in rats with experimental neuropathic pain induced by L5/6 spinal nerve ligation (SNL). Hedonic response was measured by implantation of intraoral catheters to allow passive delivery of liquid solutions and “liking/disliking” responses were scored according to a facial reactivity scale. SNL rats did not differ from controls in either “liking” or “disliking” reactions to intraoral sucrose or quinine, respectively, at post-surgery day 21, suggesting no differences in perceived hedonic value of sweet or bitter tastants. To assess possible motivational deficits during acute and chronic pain, we employed fixed- and progressive-ratio response paradigms of sucrose pellet presentation in rats with transient inflammatory or chronic neuropathic pain. Assessment of response acquisition and break points under the progressive ratio schedule revealed no differences between sham and SNL rats for up to 120 days post-injury. However, rats with inflammation showed decrements in lever pressing and break points on post-CFA days 1 and 2 that normalized by day 4, consistent with transient ongoing pain. Thus, while acute, ongoing inflammatory pain may transiently reduce reward motivation, we did not detect influences of chronic neuropathic pain on hedonic or motivational responses to food rewards. Adaptations that allow normal reward responding to food regardless of chronic pain may be of evolutionary benefit to promote survival.

show abstract

“…Behavioural alterations have been described in rat models of peripheral traumatic nerve injury (Hu et al., 2007; Blackbeard et al., 2012; Galan‐Arriero et al., 2015; Wang et al., 2015; Avila‐Martin et al., 2015; Grégoire et al., 2012), neuropathic viral infection (Hasnie et al., 2007; Wallace et al., 2007a) and drug‐induced neuropathies (Wallace et al., 2007b; Huang et al., 2013). …”

Section: Introductionmentioning

confidence: 99%

“…In animal models, the effect of nociceptive stimuli on the affective and cognitive experience can be approximated using ethologically relevant behaviours such as burrowing (Andrews et al, 2012) and thigmotaxis (Huang et al, 2013). Behavioural alterations have been described in rat models of peripheral traumatic nerve injury (Hu et al, 2007;Blackbeard et al, 2012;Galan-Arriero et al, 2015;Wang et al, 2015;Avila-Martin et al, 2015;Gr egoire et al, 2012), neuropathic viral infection (Hasnie et al, 2007;Wallace et al, 2007a) and drug-induced neuropathies (Wallace et al, 2007b;Huang et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Enhanced c‐Fos expression in the central amygdala correlates with increased thigmotaxis in rats with peripheral nerve injury

Morland

Novejarque

Spicer

et al. 2016

European Journal of Pain

View full text Add to dashboard Cite

BackgroundPain is associated with affective, cognitive and sensory dysfunction. Animal models can be used to observe ethologically relevant behaviours such as thigmotaxis, giving insight into how ongoing sensory abnormalities influence natural rodent behaviours. The amygdala is a complex group of nuclei implicated in the integration and generation of emotional behavioural responses, including those associated with pain, and a region known as the central amygdala is particularly associated with generation of behavioural responses, due to its links to the descending pain modulation pathways; as such, study of amygdalar c‐Fos immunoreactivity can help identify the neuronal circuits involved.MethodThis study investigated changes in both nociceptive evoked responses and open field behaviour following spinal nerve transection (SNT) in male Wistar rats, and attempted to correlate these with changes in central amygdala c‐Fos immunoreactivity.ResultsFourteen days after SNT, mechanical hypersensitivity was present in the hind paw ipsilateral to site of injury. Thigmotactic behaviour was significantly increased in both SNT and sham surgery animals, with c‐Fos immunoreactivity in the central amygdala significantly greater in SNT animals compared to both sham and naive groups. Activation was greatest in the capsular and lateral subnuclei of the central amygdala, and in the caudal‐most regions. There was a strong correlation between thigmotactic behaviour and central amygdala activation following SNT surgery not seen in sham animals suggesting a role for the amygdala in behavioural responses to peripheral nerve injury.ConclusionsThis study provides evidence to support the role of the amygdala in thigmotactic open field behaviour following SNT.What does this study add?Thigmotaxis and amygdala activation are positively correlated in rats following spinal nerve transection.Behavioural changes seen in sham animals did not correlate with amygdala activation, suggesting amygdala activation is related to nociceptive input.Evoked measures, such as hindpaw withdrawal, are not correlated with either thigmotaxis or amygdala activation, emphasizing the importance of complex behaviours when studying pain.

show abstract

Differential roles of hippocampal glutamatergic receptors in neuropathic anxiety-like behavior after partial sciatic nerve ligation in rats

Cited by 40 publications

References 66 publications

Reward, motivation, and emotion of pain and its relief

Reward, motivation, and emotion of pain and its relief

Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain

Enhanced c‐Fos expression in the central amygdala correlates with increased thigmotaxis in rats with peripheral nerve injury

Contact Info

Product

Resources

About