Differential spectral photic damage to primate cones

Sperling, Harry G.; Johnson, Clement; Harwerth, Ronald S.

doi:10.1016/0042-6989(80)90049-8

Cited by 113 publications

(36 citation statements)

References 12 publications

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“…The physiological significance of the presence of these xanthophyll pigments in the retina and particularly in the macula remains uncertain. LUT and ZEA are believed to help filter out damaging blue light, to improve visual acuity by attenuating light scattering and chromatic aberrations, or to quench harmful photochemically induced free radicals (18)(19)(20)(21). A direct neuroprotection of xanthophylls on photoreceptors was also reported recently (22).…”

mentioning

confidence: 99%

Xanthophylls are preferentially taken up compared with β-carotene by retinal cells via a SRBI-dependent mechanism*

During

Doraiswamy

Harrison

2008

Journal of Lipid Research

150

122

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The purpose of this study was to investigate the mechanisms by which carotenoids [xanthophylls vs. bcarotene (b-C)] are taken up by retinal pigment epithelial (RPE) cells. The human RPE cell line, ARPE-19, was used. When ARPE-19 cells were fully differentiated (7-9 weeks), the xanthophylls lutein (LUT) and zeaxanthin (ZEA) were taken up by cells to an extent 2-fold higher than b-C (P , 0.05). At 9 weeks, cellular uptakes were 1.6, 2.5, and 3.2%, respectively, for b-C, LUT, and ZEA. Similar extents were observed when carotenoids were delivered in either Tween 40 or "chylomicrons" produced by Caco-2 cells. Differentiated ARPE-19 cells did not exhibit any detectable b-C 15,15′-oxygenase activity or convert exogenous b-C into vitamin A. When using specific antibodies against the lipid transporters cluster determinant 36 (CD36) and scavenger receptor class B type I (SR-BI), cellular uptake of b-C and ZEA were significantly decreased (40-60%) with anti-SR-BI but not with anti-CD36. Small interfering RNA transfection for SR-BI led to marked knockdown of SR-BI protein expression (?90%), which resulted in decreased b-C and ZEA uptakes by 51% and 87%, respectively. Thus, the present data show that RPE cells preferentially take up xanthophylls versus the carotene by a process that appears to be entirely SR-BI-dependent for ZEA and partly so for b-C. This mechanism may explain, in part, the preferential accumulation of xanthophylls in the macula of the retina.-During, A., S. Doraiswamy, and E. H. Harrison. Xanthophylls are preferentially taken up compared with b-carotene by retinal cells via a SRBI-dependent mechanism.

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mentioning

confidence: 99%

Xanthophylls are preferentially taken up compared with β-carotene by retinal cells via a SRBI-dependent mechanism*

During

Doraiswamy

Harrison

2008

Journal of Lipid Research

150

122

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“…No change in the magnitude of DMO was detected using clinical assessment (i. e. contact, or Volk, lens fundus biomicroscopy), however, an objective morphological technique based upon the analysis of the Z-profile of a scanning laser tomographer [36] showed a post-operative increase in the magnitude of DMO in 18 of the 24 patients at visit 3 relative to visits 2 and 7 [37,38]. In addition, reversible photic damage has been found in primate cones [39,40].…”

Section: Discussionmentioning

confidence: 99%

Influence of laser photocoagulation for clinically significant diabetic macular oedema (DMO) on short-wavelength and conventional automated perimetry

et al. 1998

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“…Une atteinte couvrant 2" du champ visuel et centrée sur la fovéa, sufîït à réduire l'acuité visuelle de 50%; si la lésion couvre S", l'acuité sera diminuée d'environ 70%. Cette diminution de l'acuité visuelle est toujours le signe d'une atteinte de la région maculaire, qu'elle soit la conséquence d'une lésion anatomique ou d'un simple éblouissement (Hanverth et Sperling, 1971 ;Sperling, 1980;Zwick et al, 1983 ;Zwick, 1989). À l'inverse, une lésion de la rétine péri-phérique, qui ne provoque qu'un éblouissement passager, ne modifie pas l'acuité ou le sens chromatique.…”

Section: Dans Le Visible (400 a 760 Nm) Et L'infrarouge A (760 A 1400unclassified

Rayonnement laser : risques oculaires et normes de protection

et al. 2000

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RÉSUMÉLes propriétés optiques des tissus biologiques conditionnent de manière importante le risque d'atteinte par le faisceau laser. Les rayonnementii, émis dans I'ultraviolet mais aussi l'infrarouge B et C, représentent un danger pour le segment anté-rieur de l'oeil. Selon la longueur d'onde, le rayonnement est absorbé préférentiel-lement ou exclusivement par la cornée ou le cristallin. The risk for biological tissues to be damaged by a laser beam is mainly determined by their optical properties. Laser radiations emitted in ultraviolet and infrared B and C represent a hazard for the anterior segment of the eye. Depending the wavelength, laser radiation is absorbed by the cornea, the lem or hotb. The lower damage thresholds are reported at the retinal level, in the spectral range of 400 to 1400 nm. The exposure limit values, recommended by laser safety standards, are evaluated with wavelength, exposure duration, puise repetition frequency and the size of the visual angle subtending the source. The fast evolution of laser producîs induces a continuous revision of guidelines.

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Differential spectral photic damage to primate cones

Cited by 113 publications

References 12 publications

Xanthophylls are preferentially taken up compared with β-carotene by retinal cells via a SRBI-dependent mechanism*

Xanthophylls are preferentially taken up compared with β-carotene by retinal cells via a SRBI-dependent mechanism*

Influence of laser photocoagulation for clinically significant diabetic macular oedema (DMO) on short-wavelength and conventional automated perimetry

Rayonnement laser : risques oculaires et normes de protection

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