Differential subjective effects of d-amphetamine by gender, hormone levels and menstrual cycle phase

White, Tara L.; Justice, Angela; Wit, Harriet de

doi:10.1016/s0091-3057(02)00818-3

Cited by 228 publications

(206 citation statements)

References 45 publications

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“…Evans et al, 1999;Kosten et al, 1996;Lukas et al, 1996;Sofuoglu et al, 1999Sofuoglu et al, , 2000White et al, 2002). In the present experiment, differences between women and men were noted on only three of 28 subject-rated items.…”

Section: Discussioncontrasting

confidence: 58%

“…Women have been shown to have an enhanced response (i.e. increased ratings of stimulant-like effects) to d-amphetamine (15 mg) during the follicular phase compared to the luteal phase of their menstrual cycle and this effect is positively correlated with salivary estradiol levels (White et al, 2002). Further, administration of estradiol (0.25 mg) has been shown to enhance the discriminative-stimulus effects of a low dose of damphetamine in women (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Results from several studies suggest that men may be more sensitive to the behavioral and physiological effects of stimulants such as d-amphetamine and cocaine (e.g. Lukas et al, 1996;Sofuoglu et al, 1999Sofuoglu et al, , 2000White et al, 2002). In one study, for example, men achieved significantly higher plasma cocaine levels and reported a greater number of euphoric events compared to women following administration of 0.9 mg/kg intranasal cocaine (Lukas et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

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Similar discriminative-stimulus effects of d-amphetamine in women and men

Vansickel

Lile

Stoops

et al. 2007

Pharmacology Biochemistry and Behavior

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The results of controlled non-human animal and human laboratory studies are mixed regarding whether women and men respond differently to stimulant drugs. In order to assess potential gender differences in the effects of d-amphetamine, we conducted a retrospective-analysis of six studies conducted in our laboratory that used identical procedures and measures. Thirteen women and fourteen men learned to discriminate 15 mg oral d-amphetamine. After acquiring the discrimination (i.e., =80% correct responding on 4 consecutive sessions), the effects of a range of doses of damphetamine (0, 2.5, 5, 10, and 15 mg) alone and in combination with other drugs, were assessed. Only data from sessions in which d-amphetamine was administered alone were included in this analysis. d-Amphetamine functioned as a discriminative-stimulus and dose-dependently increased drug-appropriate responding. Women and men did not differ in their ability to discriminate damphetamine. Women and men differed on participant-ratings of high (women < men), nausea (women > men) and sluggish (women < men), women also experienced greater increases in diastolic pressure than men. Because the results of this study may have been confounded by the training procedures, future research should use other behavioral arrangements (e.g. drug self-administration) to determine if women and men respond differently to the effects of d-amphetamine.

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Similar discriminative-stimulus effects of d-amphetamine in women and men

Vansickel

Lile

Stoops

et al. 2007

Pharmacology Biochemistry and Behavior

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“…In contrast to estradiol, salivary progesterone levels were negatively correlated with the positive subjective effects of psychomotor stimulant drugs (White et al, 2002). Furthermore, in OVX female rats treated with estradiol, progesterone administration inhibited cocainemediated behaviors such as estradiol-enhanced locomotor activity and sensitization of cocaine-induced stereotyped behavior (Peris et al, 1991;Quinones-Jenab et al, 2000).…”

Section: Introductionmentioning

confidence: 90%

“…For example, females report a greater subjective response to both cocaine (Evans et al, 2002;Sofuoglu et al, 1999) and amphetamine (AMPH) (Justice and de Wit, 1999;White et al, 2002) in the follicular phase of the menstrual cycle, when estradiol is predominant, as compared to the luteal phase, when both estradiol and progesterone are elevated. Furthermore, AMPH-induced subjective effects are positively correlated with salivary estradiol levels and negatively correlated with progesterone levels (White et al, 2002). These results suggest that, in women, estradiol may potentiate the subjective responses to psychomotor stimulants compared to the effects of estradiol and progesterone together.…”

Section: Introductionmentioning

confidence: 99%

Sex Differences and Hormonal Influences on Acquisition of Cocaine Self-Administration in Rats

Jackson

Robinson

Becker

2005

Neuropsychopharmacol

285

272

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Men and women differ in their response to cocaine, and a woman's response varies with the menstrual cycle. For example, women have greater subjective responses to cocaine in the follicular phase of the menstrual cycle when estradiol is predominant, than they do during the luteal phase when both estradiol and progesterone are elevated. Similarly, female rats show significantly more cocaine-induced locomotor behavior and cocaine self-administration during behavioral estrus, shortly after estradiol peaks, than during other stages of the cycle, and estradiol administration to ovariectomized (OVX) females enhances the acquisition of cocaine self-administration. The purpose of this study was to expand upon these findings by studying the effects of progesterone administration to females, and estradiol administration to males, on acquisition of cocaine self-administration. We report here that there are both sex differences in and effects of circulating ovarian hormones on acquisition of cocaine self-administration. We demonstrate that although estradiol administration enhances acquisition of cocaine self-administration in OVX female rats, concurrent administration of progesterone with estradiol inhibits this effect of estradiol. In a separate experiment, we demonstrate that estradiol administration does not enhance acquisition of cocaine self-administration in castrated male rats. We conclude that (1) there is a sex difference in the effects of estradiol on cocaine selfadministration: it facilitates acquisition in female, but not male rats; and that (2) in females concurrent progesterone treatment counteracts the facilitory effect of estradiol on cocaine self-administration.

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Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa

Bailer

Narendran

Frankle

et al. 2011

Intl J Eating Disorders

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Objective Genetic, pharmacologic, and physiological data suggest that individuals with anorexia nervosa (AN) have altered striatal dopamine (DA) function. Method We used an amphetamine challenge and positron emission tomography [11C]raclopride paradigm to explore DA striatal transmission in 10 recovered (REC) AN compared to 9 control women (CW). Results REC AN and CW were similar for baseline, post-amphetamine [11C]raclopride binding potential (BPND) and change (Δ) in BPND for all regions. In CW, ventral striatum Δ BPND was associated with euphoria (r = − .76; p = .03), which was not found for REC AN. Instead, REC AN showed a significant relationship between anxiety and Δ BPND in the pre-commissural dorsal caudate (r = −.62, p = .05). Discussion REC AN have a positive association between endogenous DA release and anxiety in the dorsal caudate. This finding could explain why food-related DA release produces anxiety in AN, whereas feeding is pleasurable in healthy participants.

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Differential subjective effects of d-amphetamine by gender, hormone levels and menstrual cycle phase

Cited by 228 publications

References 45 publications

Similar discriminative-stimulus effects of d-amphetamine in women and men

Similar discriminative-stimulus effects of d-amphetamine in women and men

Sex Differences and Hormonal Influences on Acquisition of Cocaine Self-Administration in Rats

Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa

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