Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk: A 3-Year Follow-up Study

Domen, Patrick; Peeters, Sanne; Michielse, Stijn; Gronenschild, E. H. B. M.; Viechtbauer, Wolfgang; Roebroeck, Alard; Os, Jim van; Risk, for Genetic

doi:10.1093/schbul/sbw061

Cited by 19 publications

(19 citation statements)

References 61 publications

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“…For all LME models, we compared the Akaike Information Criteria between models with a random intercept and random slope or only a random intercept using the Log-likelihood ratio test and chose the most parsimonious model. To control for longitudinal changes in voxel selection of tracts, we included analytic weights to the LME models examining diffusion values, weighing the error variance inversely by the tract size 69 . In all LME models, age, sex and education and their interaction with time were included as covariate if p < 0.10 (using the Wald t-statistic).…”

Section: Methodsmentioning

confidence: 99%

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals

et al. 2018

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Animal models of Alzheimer’s disease (AD) have suggested that tau pathology propagation, facilitated by amyloid pathology, may occur along connected pathways. To investigate these ideas in humans, we combined amyloid scans with longitudinal data on white matter connectivity, hippocampal volume, tau positron emission tomography and memory performance in 256 cognitively healthy older individuals. Lower baseline hippocampal volume was associated with increased mean diffusivity of the connecting hippocampal cingulum bundle (HCB). HCB diffusivity predicted tau accumulation in the downstream-connected posterior cingulate cortex (PCC) in amyloid positive, not in amyloid negative individuals. Furthermore, HCB diffusivity predicted memory decline in amyloid positive individuals with high PCC tau binding. Our results provide in vivo evidence that higher amyloid pathology strengthens the association between HCB diffusivity and tau accumulation in the down-stream PCC and, facilitates memory decline. This confirms amyloid’s crucial role in potentiating neural vulnerability and cognitive decline marking the onset of preclinical AD.

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Section: Methodsmentioning

confidence: 99%

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals

et al. 2018

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“…[2][3][4] However, there have been conflicting reports in the localization of white matter alterations across previous studies, which may result from small samples, variable illness duration and antipsychotic and other drug treatment history. [5][6][7][8][9] Another potential reason for inconsistent findings in diffusion tensor imaging (DTI) studies of white matter pathways is that widespread and subtle pathology across the brain might be imperfectly detected by traditional regional or voxel-based analysis.…”

Section: Introductionmentioning

confidence: 99%

Altered White Matter Connectivity Within and Between Networks in Antipsychotic-Naive First-Episode Schizophrenia

Lui

Yao

et al. 2017

Schizophrenia Bulletin

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Analyzing the schizophrenia connectome can identify illness-related alterations in connectivity across the brain. An important question that remains unanswered is whether connectivity alterations are already evident at the onset of illness, before treatment with antipsychotic medication and possible influences of neuroprogressive or secondary alterations related to chronic illness duration. In the present study, diffusion tensor imaging and deterministic fiber tractography were performed with 137 antipsychotic-naive first-episode schizophrenia patients and 113 matched healthy controls. Using graph theoretic analysis, groups were compared in global and regional measurements and modularity of white matter connectivity. Compared with controls, the patients showed significantly decreased total connection strength. Furthermore, patients demonstrated significantly decreased connections within and between brain modules. Several local brain regions within association cortex exhibited reduced nodal centralities and abnormal participant coefficient or intra-module degree, some of which were correlated with illness duration and overall functional disability. In never-treated schizophrenia patients, networks showed a less effective organizational pattern of white matter pathways. White matter disconnectivity occurred not only within but also between multiple modules, shedding light on the deficits of anatomical network organization early in the course of schizophrenia.

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“…However, Karlsgodt et al 17 and Carletti et al 20 reported negative differences in the FA values in both ARMS-NP and ARMS-P patients at baseline. Domen et al 22 followed the siblings of patients with schizophrenia for 3 years and showed that the whole brain mean FA values of the siblings were smaller than those of HC at all the time-points.…”

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confidence: 99%

Longitudinal study examining abnormal white matter integrity using a tract‐specific analysis in individuals with a high risk for psychosis

Saito

Hori

Nemoto

et al. 2017

Psychiatry Clin Neurosci

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Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk: A 3-Year Follow-up Study

Abstract: Background: Although widespread reduced white matter (WM) integrity is a consistent finding in cross-

Cited by 19 publications

References 61 publications

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals

Altered White Matter Connectivity Within and Between Networks in Antipsychotic-Naive First-Episode Schizophrenia

Longitudinal study examining abnormal white matter integrity using a tract‐specific analysis in individuals with a high risk for psychosis

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