Differential vulnerability of the rat retina, suprachiasmatic nucleus and intergeniculate leaflet to malnutrition induced during brain development

Vilela, Maria Cristina Ramos; Mendonça, João Esmeraldo Frota; Bittencourt, Heitor; Lapa, R.M.; Alessio, M; Costa, Miriam S.M.O.; Guedes, Rubem Carlos Araújo; Silva, V.L.; Costa, Belmira L. S. Andrade da

doi:10.1016/j.brainresbull.2004.09.011

Cited by 10 publications

(6 citation statements)

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“…We chose to examine the effects of protein restriction as a means to institute malnutrition because of the significant amount of work relating how dietary protein levels influence somatic growth (Kanarek et al, 1986), the development of dendritic morphology (Benitez-Bribiesca et al, 1999; Cordero et al, 2003), neurogenesis (King et al, 2002, 2004), sensory development (Puthuraya et al, 1980; Sjostrom et al, 1984, 1985, 1987a,b; Almli et al, 1985; Conradi et al, 1985, 1989, 1990; Sjostrom and Conradi, 1987, 1989; Conradi and Sjostrom, 1989; Vilela et al, 2005), as well as influence a variety of behaviors and underlying neural circuits (Cintra et al, 1997; Morgane et al, 2002; Mokler et al, 2003). Clearly, other dietary manipulations may yield similar (or different) results than found here because insufficient amounts of a single nutrient can significantly alter nervous system development.…”

Section: Discussionmentioning

confidence: 99%

The effects of dietary protein restriction on chorda tympani nerve taste responses and terminal field organization

Thomas

Hill

2008

Neuroscience

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Prenatal dietary sodium restriction produces profound developmental effects on rat functional taste responses and formation of neural circuits in the brainstem. Converging evidence indicates that the underlying mechanisms for these effects are related to a compromised nutritional state and not to direct stimulus-receptor interactions. We explored whether early malnourishment produces similar functional and structural effects to those seen following dietary sodium restriction by using a protein deficient, sodium replete diet. To determine if early dietary protein-restriction affects the development of the peripheral gustatory system, multi-fiber neurophysiological recordings were made from the chorda tympani nerve and anterograde track tracing of the chorda tympani nerve into the nucleus of the solitary tract (NTS) was accomplished in rats fed a protein-restricted or a control diet (6% and 20%, respectively). The dietary regimens began on embryonic day 7 and continued until rats were used for neurophysiological recordings (postnatal days (P) 35-50) or for chorda tympani terminal field labeling (P40-50). Responses to a concentration series of NaCl, sodium acetate, KCl, and to 0.50 M sucrose, 0.03 M quinine-HCl, and 0.01 N HCl revealed attenuated responses (30-60%) to sodium-specific stimuli in rats fed the 6% protein diet compared with those fed the 20% protein diet. Responses to all other stimuli were similar between groups. Terminal field volumes were nearly twofold larger in protein-restricted rats compared with controls, with the differences located primarily in the dorsal-caudal zone of the terminal field. These results are similar to the results seen previously in rats fed a sodium-restricted diet throughout pre-and postnatal development, suggesting that dietary sodium-and protein-restriction share similar mechanisms in altering gustatory development. Keywordsnucleus of the solitary tract; gustation; development; prenatal diet; plasticity . E-mail address: dh2t@virginia.edu (D. L. Hill). Publisher's Disclaimer: This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: http://www.elsevier.com/copyright NIH Public Access Sensory systems adapt to environmental influences by coordinated alterations in structure and function, often referred to as "plastic" changes. Unlike other sensory systems, there is a remarkable amount of environmentally induced plasticity resident in peripheral and brainstem g...

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Section: Discussionmentioning

confidence: 99%

The effects of dietary protein restriction on chorda tympani nerve taste responses and terminal field organization

Thomas

Hill

2008

Neuroscience

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“…That aged, well-nourished rats displayed poor entrainment to SP together with the fact that a larger number of malnourished animals entrained to the skeleton photoperiod than well-nourished rats, reinforces the observation that a non-significant difference seems to occur in the circadian photic pathway during prenatal malnutrition. 21 It is possible that differences observed in well-nourished compared with PM rats might be due to the degenerative effects of aging on circadian photic pathways, being stronger in well-nourished animals; nevertheless, malnourished rats that entrain to SP take about 10-15 cycles to phase lock any of the pulses (Fig. 2) as happens in younger animals.…”

Section: Discussionmentioning

confidence: 98%

Protein malnutrition and aging affects entraining and intensity of locomotor activity and body temperature circadian rhythms in rats

Durán

Miranda‐Anaya

Mondragón-García

et al. 2008

Nutritional Neuroscience

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Independently, chronic protein malnutrition and aging have been shown to affect locomotor activity (LA) and body temperature (BT) rhythms in mammals. The objective of the present study was to ascertain the combined effects of these two factors by examining period, entrainment and other circadian parameters between LA and BT rhythms. Chronic protein malnourished (PM) and well-nourished (WN) male Sprague-Dawley rats (550-590 days of age) were implanted with activity temperature intraperitoneal radio transmitters (Mini Mitter) and exposed to different lighting protocols during at least 10 days - light-dark cycles (LD 12:12), constant darkness (DD), skeleton photoperiod (SP) and again LD. Results indicate that parametric entrainment, achieved by means of complete photoperiod, is not negatively affected in malnourished rats; however, it is affected under non-parametric entrainment like SP. A different free running period between the LA and BT circadian rhythms was detected for well-nourished and malnourished aged rats.

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“…Esta diferença entre grupos nutricionais é amplamente documentada, mostrando a eficácia do procedimento em causar o insulto nutricional (Almeida, & De Araújo, 2001;Feoli et al, 2006;Riul et al, 1999;Rocinholi et al, 1997;Vilela et al, 2005). Devido à restrição proteica na dieta consumida pelas ratas mães desnutridas durante o período de lactação, provavelmente houve uma redução na disponibilidade de aminoácidos para síntese de proteínas do leite, o que teria gerado a perda de peso da prole dessas ratas (Passos, Ramos, & Moura, 2000).…”

Section: Discussionunclassified

Desnutrição Proteica Precoce Reduz O Intervalo Entre Tentativas De Ratos Em Tarefa De Discriminação Condicional

Silva¹,

Oliveira²,

Almeida³

2016

REBAC

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RESUMOA má nutrição precoce gera efeitos deletérios graves no crescimento, no comportamento e nas capacidades cognitivas de diferentes organismos, sendo a desnutrição proteica a principal insuficiência nutricional que pode ser examinada individualmente em estudos experimentais. O objetivo deste estudo foi testar o procedimento de correção de tentativas diretamente no treino de discriminação condicional, comparando o desempenho de animais previamente desnutridos e recuperados nutricionalmente, com o desempenho de animais controles. As curvas de desempenho dos grupos não indicaram uma melhora significativa nos acertos ao longo das sessões, mas ao final do treino os animais submetidos ao procedimento de correção de tentativas apresentaram melhor desempenho do que os animais não submetidos à correção. Os animais desnutridos apresentaram IETs médios menores do que os IETs apresentados pelos animais bem nutridos. Entre os fatores apontados como responsáveis pela não aprendizagem da discriminação condicional, destacam-se a programação da contingência e a disposição espacial aleatória dos estímulos de escolha durante o treino. Palavras-chave: desnutrição proteica; aprendizagem; discriminação condicional; correção de tentativas; IET. ABSTRACTEarly malnutrition generates severe deleterious effects on growth, behavior and cognitive abilities of different organisms, and protein malnutrition is the main nutritional insufficiency that can be examined individually in experimental studies. The aim of this study was to establish conditional discriminations in rats, comparing malnourished animals which have received nutritional recovery with control ones, and test the effects of a correction procedure. Even though animals under the correction procedure have performed better than the animals not submitted to it, their performances did not improve during training sessions. Malnourished animals showed lower average ITIs than wellnourished animals. Contingency planning and the random spatial presentation of choice stimuli are the factors pointed out as potentially responsible for the absence of a learning curve to the conditional discrimination, at the end of training.

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Differential vulnerability of the rat retina, suprachiasmatic nucleus and intergeniculate leaflet to malnutrition induced during brain development

Cited by 10 publications

References 55 publications

The effects of dietary protein restriction on chorda tympani nerve taste responses and terminal field organization

The effects of dietary protein restriction on chorda tympani nerve taste responses and terminal field organization

Protein malnutrition and aging affects entraining and intensity of locomotor activity and body temperature circadian rhythms in rats

Desnutrição Proteica Precoce Reduz O Intervalo Entre Tentativas De Ratos Em Tarefa De Discriminação Condicional

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