Differentially expressed gene profiles in the serum before and after the ultrasound-guided ethanol sclerotherapy in patients with ovarian endometriomas

Wang, Lulu; Cai, Hongbo; Xiao, Dong; Zhang, Liwei; Jiang, Shanshan; Zhao, Ning; Shao, Xiaotong; Wang, Siming; Zhu, Li; Zhang, Tong

doi:10.1016/j.clinbiochem.2015.06.003

Cited by 6 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, patients without a history of sexual activity are not suitable for a transvaginal puncture. Findings in animal experiments showed that when the concentration of lauryl alcohol is maintained above 0.25%, injection into the cyst model without extraction helps to enhance the sclerosis effect [ 22 – 26 ], and the efficacy is close to that of the use of absolute ethanol method [ 14 , 27 ]. The combination of anhydrous medical ethanol with lauryl alcohol sclerotherapy to treat OEC through the transvaginal puncture route could achieve good clinical efficacy.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that the incidence of abdominal pain during sclerotherapy with medical alcohol in OEC is as high as 52.3% (23/44), incidence of postoperative abdominal pain is as high as 100% (44/44), and pain was not evaluated quantitatively. However, during surgery of puncture and hardening therapy of the skin in treating OECs, the common obstacles include unclear cyst display or large omentum obstruction [ 22 – 26 ], no safe puncture path that can be observed or determined, and severe pain caused by leakage stimulation and mini-reflex reflection in patients [ 22 , 25 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pelvic Artificial Isolation with Ultrasound-Guided Fluid: A New Technique In Ovarian Endometriotic Cyst Transabdominal Sclerotherapy

Meng¹,

Xu²

2022

Med Sci Monit

View full text Add to dashboard Cite

Background The aim of this study was to investigate the preparation method and effect of artificial pelvic fluid during the sclerotherapy of ovarian endometrioma cysts guided by ultrasound through an abdominal wall puncture. Material/Methods Under the guidance of ultrasound, a total of 70 cases of artificial pelvic isolation fluid were isolated during the sclerosis of ovarian endometrioma cysts through an abdominal wall puncture. The success rate, time required, intraoperative pain incidence, vagal reflex incidence, related complications, and efficacy of artificial pelvic isolation fluid were summarized and analyzed. Results The results showed that the success rate of artificial pelvic isolation fluid was 100%, the average time of surgery was 9.1±1.3 min, the incidence of intraoperative pain was 5.71% (4/70), and the incidence of vagal reflex was 2.86% (2/70). No complications, such as bleeding, intestinal perforation, or infection, occurred. After 12 months of follow-up, the cure rate was 97.14% (68/70) and the effective rate was 100% (70/70). Conclusions We were first to use artificial pelvic isolation fluid technology to solve the problems of unclear cyst display, lack of safe puncture path, and severe pain during or after surgery in patients, and to exhibit a high level of intraoperative comfort for patients with a safe and effective clinical treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pelvic Artificial Isolation with Ultrasound-Guided Fluid: A New Technique In Ovarian Endometriotic Cyst Transabdominal Sclerotherapy

Meng¹,

Xu²

2022

Med Sci Monit

View full text Add to dashboard Cite

show abstract

“…Rao et al [ 31 ] reported that combined overexpression of OVA66 and MDM2 promotes oncogenesis by enhancing activation of the IGF-1R–ERK1/2 signaling pathway, and JAG1 enhances ovarian cancer cell growth and cisplatin-resistance [ 32 ]. The expression of HES1 is confirmed to be strongly associated with the pathogenesis of ovarian endometriomas [ 33 ]. Meanwhile, decreased NOTCH2 expression is associated with the poorly differentiated serous epithelial ovarian carcinoma histology [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

A powerful score-based statistical test for group difference in weighted biological networks

Yuan

Zhang

et al. 2016

BMC Bioinformatics

View full text Add to dashboard Cite

BackgroundComplex disease is largely determined by a number of biomolecules interwoven into networks, rather than a single biomolecule. A key but inadequately addressed issue is how to test possible differences of the networks between two groups. Group-level comparison of network properties may shed light on underlying disease mechanisms and benefit the design of drug targets for complex diseases. We therefore proposed a powerful score-based statistic to detect group difference in weighted networks, which simultaneously capture the vertex changes and edge changes.ResultsSimulation studies indicated that the proposed network difference measure (NetDifM) was stable and outperformed other methods existed, under various sample sizes and network topology structure. One application to real data about GWAS of leprosy successfully identified the specific gene interaction network contributing to leprosy. For additional gene expression data of ovarian cancer, two candidate subnetworks, PI3K-AKT and Notch signaling pathways, were considered and identified respectively.ConclusionsThe proposed method, accounting for the vertex changes and edge changes simultaneously, is valid and powerful to capture the group difference of biological networks.Electronic supplementary materialThe online version of this article (doi:10.1186/s12859-016-0916-x) contains supplementary material, which is available to authorized users.

show abstract

“…The mechanism of action could combine cytotoxic damage, cell dehydration, coagulation and thrombosis [48]. Wang et al identified differentially expressed genes and potential serum biomarkers in women with endometrioma before and after EST [49]. They reported that the expressions of interleukin-6 (IL6), CD36, JUNB, B4GALT1, HES1, and NR4A1 gene, which are strongly associated with the pathogenesis of ovarian endometrioma, was significantly down regulated after EST.…”

Section: Plos Onementioning

confidence: 99%

Endometrioma ethanol sclerotherapy could increase IVF live birth rate in women with moderate-severe endometriosis

et al. 2020

View full text Add to dashboard Cite

Objective To examine the impact of ethanol sclerotherapy (EST) for endometrioma on in vitro fertilization (IVF) cumulative live birth rates (CLBR) in women with moderate-severe endometriosis. Methods This retrospective cohort study included women with moderate-severe endometriosis (revised American Fertility Society stage III-IV) and endometrioma who underwent IVF with the ultra-long agonist protocol. We compared two groups: women undergoing EST for endometrioma before IVF (EST group), and women whose endometrioma was left in situ during IVF (No-EST group). The primary outcome was the CLBR per IVF cycle, including fresh and frozen embryo transfers. The secondary endpoints included the complication rate, number of mature oocytes retrieved, clinical pregnancy rate and pregnancy loss rate. Results Seventy-four women were included in the study, with 37 in the EST group and 37 in the No-EST group, representing 67 and 69 IVF cycles, respectively. The population and cycle characteristics were comparable between the two groups, especially the ovarian response to stimulation. The CLBR was significantly increased in the EST group compared to the No-EST group (31.3% vs. 14.5%, p = 0.03). The clinical and biochemical pregnancy rates were significantly increased in the EST group (37.3% vs. 15.9%, p = 0.01 and 43.3% vs. 23.2%, p = 0.01, respectively). Multivariate analysis revealed a significantly increased chance of live birth in women exposed to EST before IVF with an adjusted OR of 2.68 (95% confidence interval, CI: 1.13-6.36, p = 0.02). In the EST group, we reported one major complication Clavien and Dindo classification grade III, complication involving an ovarian abscess that required a laparoscopic drainage.

show abstract

Differentially expressed gene profiles in the serum before and after the ultrasound-guided ethanol sclerotherapy in patients with ovarian endometriomas

Cited by 6 publications

References 33 publications

Pelvic Artificial Isolation with Ultrasound-Guided Fluid: A New Technique In Ovarian Endometriotic Cyst Transabdominal Sclerotherapy

Pelvic Artificial Isolation with Ultrasound-Guided Fluid: A New Technique In Ovarian Endometriotic Cyst Transabdominal Sclerotherapy

A powerful score-based statistical test for group difference in weighted biological networks

Endometrioma ethanol sclerotherapy could increase IVF live birth rate in women with moderate-severe endometriosis

Contact Info

Product

Resources

About