Differentiated Embryo Chondrocyte 1 (DEC1) Represses PPARγ2 Gene through Interacting with CCAAT/Enhancer Binding Protein β (C/EBPβ)

Park, Young-Kwon; Park, Hyunsung

doi:10.1007/s10059-012-0002-9

Cited by 30 publications

(32 citation statements)

References 23 publications

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“…Thus, C/EBPβ interacts with the transcription repressors deleted in esophageal cancer 1 (Park and Park 2012) and death domain associated protein (Wethkamp and Klempnauer 2009) and with the histone demethylases Jmjd3 (Lee et al 2012a) and Kdm4b (Guo et al 2012). …”

Section: Functional Interaction Between C/ebpβ and Other Coregulatorsmentioning

confidence: 95%

C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS

Pulido-Salgado

Vidal-Taboada

Saura

2015

Progress in Neurobiology

141

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Section: Functional Interaction Between C/ebpβ and Other Coregulatorsmentioning

confidence: 95%

C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS

Pulido-Salgado

Vidal-Taboada

Saura

2015

Progress in Neurobiology

141

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“…DEC1 and DEC2 act as negative regulators of adipogenesis by inhibiting the activity of C/EBP-α and C/EBP-β, key transcriptional mediators of the early stage of adipogenesis (Gulbagci et al, 2009;Matsunaga et al, 2012;Park & Park, 2012;Yun, Maecker, Johnson, & Giaccia, 2002). DEC1 represses Pparγ2 promoter activity through the C/EBP binding site.…”

Section: Other Factorsmentioning

confidence: 99%

DEC1/STRA13/SHARP2 and DEC2/SHARP1 Coordinate Physiological Processes, Including Circadian Rhythms in Response to Environmental Stimuli

Kato

Kawamoto

Fujimoto

et al. 2014

Current Topics in Developmental Biology

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“…BHLHE41 suppressed VEGF transcription by interacting with HIF1A (8). BHLHE40 and BHLHE41 were reported to associate with retinoid X receptor (RXR), MYOD1, or CEBP in order to regulate the transcription of their target genes (9)(10)(11)(12).…”

mentioning

confidence: 99%

Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells

Asanoma

Liu

Yamane

et al. 2015

Molecular and Cellular Biology

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c BHLHE40 and BHLHE41 (BHLHE40/41) are basic helix-loop-helix type transcription factors that play key roles in multiple cell behaviors. BHLHE40/41 were recently shown to be involved in an epithelial-to-mesenchymal transition (EMT). However, the precise mechanism of EMT control by BHLHE40/41 remains unclear. In the present study, we demonstrated that BHLHE40/41 expression was controlled in a pathological stage-dependent manner in human endometrial cancer (HEC). Our in vitro assays showed that BHLHE40/41 suppressed tumor cell invasion. BHLHE40/41 also suppressed the transcription of the EMT effectors SNAI1, SNAI2, and TWIST1. We identified the critical promoter regions of TWIST1 for its basal transcriptional activity. We elucidated that the transcription factor SP1 was involved in the basal transcriptional activity of TWIST1 and that BHLHE40/41 competed with SP1 for DNA binding to regulate gene transcription. This study is the first to report the detailed functions of BHLHE40 and BHLHE41 in the suppression of EMT effectors in vitro. Our results suggest that BHLHE40/41 suppress tumor cell invasion by inhibiting EMT in tumor cells. We propose that BHLHE40/41 are promising markers to predict the aggressiveness of each HEC case and that molecular targeting strategies involving BHLHE40/41 and SP1 may effectively regulate HEC progression. Basic helix-loop-helix (bHLH) type transcription factors play key roles in cell differentiation, proliferation, apoptosis, and metabolism. BHLHE40 (basic helix-loop-helix family member e40 gene) and BHLHE41 are members of the Hairy/E(spl)/HES family. BHLHE40 and BHLHE41 (BHLHE40/41) exhibit more than 90% similarity in the bHLH region and approximately 50% in total. BHLHE40/41 have been shown to function as transcriptional repressors by binding to the class B E-box. BHLHE40/41 interact with TF2B, TBP, or TF2D or recruit a histone deacetylase at the E-box site (1-5). On the other hand, BHLHE40/41 were previously reported to modulate the expression of some genes in an E-box-independent manner. BHLHE40 has been shown to associate with SP1 binding sites in the BIRC5 promoter to activate its transcription (6) and with STAT3 to regulate the transcription of STAT3-dependent target genes (7). BHLHE41 suppressed VEGF transcription by interacting with HIF1A (8). BHLHE40 and BHLHE41 were reported to associate with retinoid X receptor (RXR), MYOD1, or CEBP in order to regulate the transcription of their target genes (9-12).In diverse types of cancer species, such as colon, oral, and liver cancer or brain tumors, BHLHE40 expression levels were found to be higher in tumors than in adjacent normal tissues (13-15). On the other hand, in human endometrial cancer (HEC) and nonsmall-cell lung cancer, no changes in BHLHE40 expression were reported between cancer and normal tissues (16,17). Regarding expression profiles with the development of cancer, studies on oral, lung, liver, and esophageal cancer showed that BHLHE40 expression inversely correlated with the tumor stage or differentiation grade (18-21)...

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Differentiated Embryo Chondrocyte 1 (DEC1) Represses PPARγ2 Gene through Interacting with CCAAT/Enhancer Binding Protein β (C/EBPβ)

Cited by 30 publications

References 23 publications

C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS

C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS

DEC1/STRA13/SHARP2 and DEC2/SHARP1 Coordinate Physiological Processes, Including Circadian Rhythms in Response to Environmental Stimuli

Regulation of the Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells

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