Differentiating Alzheimer’s disease from subcortical vascular dementia with the FAB test

Oguro, Hiroaki; Yamaguchi, Shûhei; Abe, Satoshi; Ishida, Yusuke; Bokura, Hirokazu; Kobayashi, Shotai

doi:10.1007/s00415-006-0251-7

Cited by 42 publications

(50 citation statements)

References 20 publications

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“…Existing validation studies observed cutoffs of 11/12 for executive dysfunction in subcortical infarct (Sn: 69.2%, Sp: 87.7%, Ac: 80.6%) [9] and differentiated AD (cutoff 11/12; Sn: 77%, Sp: 87%) [2] from frontotemporal dementia (cutoff 10/11; Sn: 85–92%, Sp: 85%) [8]. The cutoff scores in our study are more similar to the normative values in an Italian population control sample [15]. This is likely related to the fact that we included subjects in the earlier stages of cognitive impairment with CDR scores ≤1 [37] and the use of community-dwelling healthy elderly controls who met the operational definition of cognitively normal (in contrast to including subjects presenting to the specialist memory clinic with subjective memory complaints who were subsequently diagnosed as normal following evaluation).…”

Section: Discussionsupporting

confidence: 60%

“…Most of the previous work on the FAB has focused on the differentiation of Alzheimer’s disease (AD) from frontotemporal dementia [11,12,13,14], subcortical vascular dementia (VaD) [15] and (more recently) dementia with Lewy Body [16]. Existing validation studies report a range of cutoffs, either in the use of the FAB for detecting executive dysfunction in subcortical infarct (cutoff 11/12 [9]) or for differentiating AD from frontotemporal dementia (cutoff 11/12 [11] and 10/11 [14,17]).…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Performance of the Chinese Frontal Assessment Battery in Early Cognitive Impairment in an Asian Population

Chong

Lim

Chan³

et al. 2010

Dement Geriatr Cogn Disord

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Background: The Frontal Assessment Battery (FAB) has been shown to be useful in evaluating frontal dysfunction. There is a paucity of studies validating cutoffs in the early cognitive impairment. We aim to validate the Chinese FAB in Asian subjects with mild cognitive impairment (MCI) and early dementia. Methods: Eighty subjects with MCI and mild dementia and 100 cognitively healthy community subjects were studied. ROC analysis was done to determine the Chinese FAB’s optimal cutoff scores for age- and education-adjusted subgroups. Results: Chinese FAB scores were significantly lower in early cognitive impairment compared with cognitively normal controls. The optimal cutoff score was 12/13 (sensitivity 92%, specificity 78.7%). A similar cutoff score was obtained following age-adjustment and for subjects with <6 years’ education. Of note, the optimal cutoff for subjects with ≧6 years’ education was 13/14 (sensitivity 91.8%, specificity 70.3%), an improved diagnostic performance compared to the earlier reported 11/12 cutoff. In comparison, the Mini-Mental Status Examination (MMSE) had lower rule-out accuracy (77% sensitivity, 91.2% specificity). The combination of the Chinese FAB and MMSE was superior to either test in isolation. Conclusion: The education-adjusted Chinese FAB has good diagnostic performance, which can supplement the MMSE in early cognitive impairment evaluation with construct differences observed between the Chinese FAB and MMSE.

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Diagnostic Performance of the Chinese Frontal Assessment Battery in Early Cognitive Impairment in an Asian Population

Chong

Lim

Chan³

et al. 2010

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

“…The Frontal Assessment Battery (FAB; Dubois, Slachevsky, Litvan, & Pillon, 2000 ) is an executive screening test that, over the last years, has become widely used in neurological research (Guedj et al, 2008 ;Lima, Meireles, Fonseca, Castro, & Garrett, 2008 ;Oguro et al, 2006 ;Santangelo et al, 2009 ;Yoshida et al, 2009 ). It consists of six subtests assessing conceptualization, cognitive fl exibility, motor programming, sensitivity to interference, motor inhibitory control, and prehension behavior.…”

Section: Introductionmentioning

confidence: 99%

INECO Frontal Screening (IFS): A brief, sensitive, and specific tool to assess executive functions in dementia – ERRATUM

Torralva¹,

Roca²,

Gleichgerrcht³

et al. 2009

J Int Neuropsychol Soc

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“…Only a few studies have examined the discriminative ability of the FAB for patients with AD and vascular cognitive impairment (VCI) [24,46,47]. Taking into consideration performance on individual subtests in addition to the total score of the FAB has generally been reported to result in better discriminative power [24,46].…”

Section: Discussionmentioning

confidence: 99%

“…Researchers have discovered that neural substrates related to performances on the FAB include both cortical and subcortical areas, such as the middle frontal gyrus, inferior frontal, insula [22], callosomarginal, and precentral regions [23]. Previous studies have also shown that the FAB is useful in differentiating AD from subcortical VaD [24]. However, the discriminative power of the FAB at an earlier pre-dementia stage and the neural correlates of FAB performance have yet to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Frontal Assessment Battery as a Useful Tool to Differentiate Mild Cognitive Impairment due to Subcortical Ischemic Vascular Disease from Alzheimer Disease

Hsu

Huang

et al. 2016

Dement Geriatr Cogn Disord

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Background: Prominent executive dysfunction can differentiate vascular dementia from Alzheimer disease (AD). However, it is unclear whether the Frontal Assessment Battery (FAB) screening tool can differentiate subcortical ischemic vascular disease (SIVD) from AD at the pre-dementia stage. In addition, the neural correlates of FAB performance have yet to be clarified. Methods: Patients with mild cognitive impairment (MCI) due to SIVD (MCI-V), MCI due to AD (MCI-A), and demographically matched controls completed the Mini-Mental State Examination, Taiwanese FAB (TFAB), Category Fluency, and Chinese Version of the Verbal Learning Test, and underwent magnetic resonance imaging. White matter hyperintensities were rated according to the Scheltens scale. Results: TFAB total scale and its Orthographical Fluency subtest were the only measures that could differentiate MCI-V from MCI-A. Discriminative analysis showed that Orthographical Fluency scores successfully identified 73.2% of the cases with MCI-V, with 85.0% sensitivity. Orthographical Fluency scores were specifically associated with lesion load within frontal periventricular, frontal deep white matter, and basal ganglia regions. Conclusion: The TFAB, and especially its 1-min Orthographical Fluency subtest, is a useful screening procedure to differentiate MCI due to SIVD from MCI due to AD. The discriminative ability is probably due to frontosubcortical white matter pathologies disproportionately involved in the two disease entities.

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Differentiating Alzheimer’s disease from subcortical vascular dementia with the FAB test

Abstract: The FAB test can provide useful information for differentiating AD and VD at the bedside.

Cited by 42 publications

References 20 publications

Diagnostic Performance of the Chinese Frontal Assessment Battery in Early Cognitive Impairment in an Asian Population

Diagnostic Performance of the Chinese Frontal Assessment Battery in Early Cognitive Impairment in an Asian Population

INECO Frontal Screening (IFS): A brief, sensitive, and specific tool to assess executive functions in dementia – ERRATUM

Frontal Assessment Battery as a Useful Tool to Differentiate Mild Cognitive Impairment due to Subcortical Ischemic Vascular Disease from Alzheimer Disease

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