Differentiation of benign and malignant uterine corpus tumors by using proton MR spectroscopy at 3T: preliminary study

Abstract

Proton MR spectroscopy with quantitative evaluation of tCho concentration can provide helpful information in distinguishing benign and malignant uterine corpus tumours.

Preliminary observations and clinical value of N-acetyl resonances in ovarian tumours using in-vivo proton MR spectroscopy at 3T

“…McLean et al and Takeuchi et al applied LCModel to quantify the choline concentration in evaluating ovarian tumours and uterine corpus tumours, respectively [7,13]. They found that MR spectroscopy could be measured at 3T with acceptable spectral quality and good signal-to-noise ratio for quantitative analysis of metabolites [7,13]. In our study MR spectroscopic data obtained at 3T were also good for the qualitative and quantitative evaluation.…”

“…In several studies LCModel has been applied for the quantification of metabolites in gynaecologic tumours [7,13,26,27]. McLean et al and Takeuchi et al applied LCModel to quantify the choline concentration in evaluating ovarian tumours and uterine corpus tumours, respectively [7,13]. They found that MR spectroscopy could be measured at 3T with acceptable spectral quality and good signal-to-noise ratio for quantitative analysis of metabolites [7,13].…”

“…We used LCModel for the quantification of the metabolite level at 2 ppm as "NAA" and revealed significant high concentration of the metabolite level at 2 ppm in mucinous tumours. In several studies LCModel has been applied for the quantification of metabolites in gynaecologic tumours [7,13,26,27]. McLean et al and Takeuchi et al applied LCModel to quantify the choline concentration in evaluating ovarian tumours and uterine corpus tumours, respectively [7,13].…”

“…The choline peak may be observed in solid tumoral components reflecting metabolic activity of tumour cells and tend to show higher peaks in malignant tumours [6]. In gynaecologic tumours, the quantitative evaluation of the choline concentration can provide helpful information in distinguishing benign and malignant uterine corpus tumours [7]. However, detecting the choline concentration in the tumour may not contribute to differential diagnosis of subtypes in ovarian tumours.…”

Proton magnetic resonance spectroscopy in oncology: the fingerprints of cancer?

“…However, there are some contradictory data. In studies regarding the uterine tumors, Okada et al (59) and Celik et al (60) found that choline was present in benign and malignant lesions, while Takeuchi et al (61) reported that malignant lesions have higher levels of choline, and a cutoff of 7 mmol might distinguish between them with 83% sensitivity and 93% specificity. Lipid peaks also showed promising results for distinguishing uterine sarcomas from benign leiomyomas (62).…”