Differentiation of Nigella sativa seeds from four different origins and their bioactivity correlations based on NMR-metabolomics approach

Maulidiani, M.; Sheikh, Bassem Y.; Mediani, Ahmed; Wei, Leong Sze; Ismail, Intan Safinar; Abas, Faridah; Lajis, Nordin Hj

doi:10.1016/j.phytol.2015.07.012

Cited by 35 publications

(24 citation statements)

References 43 publications

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“…The non‐targeted metabolite profiling was conducted for the Algerian DPF crude extracts using 1 H‐NMR spectroscopy. Following the identification process, 49 compounds were tentatively assigned based on the comparison with the previous literature and the Chenomx database (Diboun et al, ; Farag et al, ; Farag, Mohsen, Heinke, & Wessjohann, ; Maulidiani et al, ). The spectroscopic data and the compound IDs are summarized in Table S2 Supporting information.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical characteristics, nutritional composition, and phytochemical profiles of nine Algerian date palm fruit (Phoenix dactyliferaL.) varieties

et al. 2018

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Nine varieties of Algerian date palm fruits (Phoenix dactylifera L.) including Lahmira, Timjouhert, Adham Talmine, Deglet Talmine, Adam Boullah, Tinasser, Deglet, Deglet Nour, and Takerbouch were distinguished via Proton Nuclear Magnetic Resonance (1H‐NMR) metabolomics approach. The quality was evaluated based on the metabolite composition, proximate analysis, physicochemical characteristics, and biological activities which include nitric oxide (NO) inhibition via the cell‐based approach and NO scavenging abilities. A total of 49 metabolites were tentatively characterized including amino acids, organic acids, and phenolic compounds. The Principal Component Analysis and Hierarchical Clustering Analysis revealed a consistent grouping of Deglet, Takerbouch, and Deglet Noor from the rest of six varieties. Among the metabolites that contributed toward the observed segregation were serine, glycine, glucose, fructose, and sucrose. With regard to metabolite composition, NO scavenging activities, total soluble solids, and proximate analysis, Deglet dates displayed a better quality as compared to the other Algerian dates. Practical applications The present study has the significance in assessing the variation among different varieties of Algerian dates via the 1H‐NMR metabolomics approach. The information gained might be beneficial for consumers and suppliers regarding the quality of the selected varieties of date palm fruits. Generally, the obtained data intend to contribute to the knowledge on the quality differences among varieties of dates. Thus, the selection of premium date variety with good nutritional and pharmacological values can be chosen in the development of functional food.

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Section: Resultsmentioning

confidence: 99%

Physicochemical characteristics, nutritional composition, and phytochemical profiles of nine Algerian date palm fruit (Phoenix dactyliferaL.) varieties

et al. 2018

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“…Furthermore, acute toxicity study with date palm extract prior to our project on biological investigation of date extracts revealed extended period of sleep in test animals. All these observations prompted us, as a part of our research on Prophetic medicine (El-Ameen et al 2015; Halabi and Sheikh 2014; Maulidiani et al 2015; Taha et al 2015), to evaluate and compare neuropharmacological effects of two date cultivars growing in Madinah (Ajwah and Safawy) and one growing outside Madinah but within Saudi Arabia (Sukkari).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (Phoenix dactylifera)

Sheikh

Zihad

Sifat

et al. 2016

Orient Pharm Exp Med

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In addition to the rich nutritional value, date palm is also used in various ethnobotanical practices for the treatment of various disease conditions. Present investigation was undertaken to examine the neuropharmacological and antinociceptive effect of the ethanol extract of three date cultivars growing in Saudi Arabia, namely Ajwah, Safawy and Sukkari. Neuropharmacological effect was observed by pentobarbitone induced sleeping time, open field, and hole board test. Antinociceptive activity was tested by acetic acid induced writhing and hot plate test. The date extracts were also subjected to HPLC analysis to detect the presence of common bioactive polyphenols. All the three date extracts extended the pentobarbitone induced sleeping time, reduced locomotor activity in open field test and reduced exploratory behaviour in hole board test in mice. The extracts also reduced acetic acid induced writhing and delayed response time in hot plate test. The activities were stronger for Ajwah than the other two date cultivars. HPLC analysis indicated the presence of trans-ferulic acid in all three cultivars, while (+)-catechin and (−)-epicatechin only in Ajwah and Safawy. The observed neuropharmacological and analgesic activity could be partly due to the presence of (+)-catechin, (−)-epicatechin and trans-ferulic acid, three important plant polyphenols well known for their neuroprotective activity and their ability to exert antioxidant activity on brain cells. Present investigation also supports the ethnobotanical use of date palm to provide ameliorating effects in pain and CNS disorders.Electronic supplementary materialThe online version of this article (doi:10.1007/s13596-016-0239-5) contains supplementary material, which is available to authorized users.

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“…PLS‐DA of 162 metabolites of all different samples resulted in complete separation into different groups. PLS model established the relationship between the different samples using the analysed metabolites identified by UPLC‐MS and HPTLC and this model can be used for metabolic discrimination that was a previous study agreement . Using PLS‐DA, the biplot (Figure B) showing a well‐defined separation of metabolite present in different samples follows a direction combining the first and second components.…”

Section: Resultsmentioning

confidence: 85%

Metabolic differentiation and quantification of gymnemic acid in Gymnema sylvestre (Retz.) R.Br. ex Sm. leaf extract and its fermented products

Khan

Sheoran

Khan

et al. 2020

Phytochemical Analysis

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Introduction Gymnemagenin is the bioactive metabolite found in Gymnema sylvestre leaves and possesses different therapeutic potential. Due to its lower abundance and higher market potential, gymnemagenin was obtained from chemical conversion and bacterial biotransformation. Objective To obtain the probiotic‐based fermentative conversion of gymnemic acid‐enriched G. sylvestre leaf extract to gymnemagenin‐containing nutraceuticals and its metabolites based chromatographic comparison. Material and Methods Gymnema sylvestre leaves were extracted through soxhalation, and the extract was prepared and characterised. Gymnemic acid was fermented, separately, by Lactobacillus casei, Lactobacillus rhamnosus, Bifidobacterium bifidum, and by their mix co‐culture. The fermented materials were analysed for their gymnemagenin content, antioxidant potential, antidiabetic potential, and metabolomics analysis. Results Extraction yielded about 35% w/w of raw plant material, and 8.5% was found to be as total saponin content. Extract at higher concentration (≥ 5%, w/v) significantly altered the growth behaviour of probiotics. High‐performance thin‐layer chromatography (HPTLC) based quantification of gymnemagenin revealed that a maximum increase of 95.5% gymnemagenin was found in extract incubated with B. bifidum followed by mix co‐culture containing (B. bifidum, L. casei, and L. rhamnosus), L. casei, and L. rhamnosus. However, liquid chromatography mass spectrometry (LC‐MS) analysis resulted in the identification of a total of 56 metabolites. Conclusion Chromatographically profiled, and probiotic‐based fermented G. sylvestre leaves can be used as a potent nutraceutical for diabetes and other metabolic disorders.

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Differentiation of Nigella sativa seeds from four different origins and their bioactivity correlations based on NMR-metabolomics approach

Cited by 35 publications

References 43 publications

Physicochemical characteristics, nutritional composition, and phytochemical profiles of nine Algerian date palm fruit (Phoenix dactyliferaL.) varieties

Physicochemical characteristics, nutritional composition, and phytochemical profiles of nine Algerian date palm fruit (Phoenix dactyliferaL.) varieties

Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (Phoenix dactylifera)

Metabolic differentiation and quantification of gymnemic acid in Gymnema sylvestre (Retz.) R.Br. ex Sm. leaf extract and its fermented products

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