Differentiation of Recurrent Nasopharyngeal Carcinoma and Skull Base Osteoradionecrosis by Epstein‐Barr Virus‐Derived Latent Membrane Protein‐1 Gene

Hao, Sheng‐Po; Tsang, Ngan‐Ming; Chang, Kai‐Ping

doi:10.1097/00005537-200104000-00017

Cited by 15 publications

(16 citation statements)

References 14 publications

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“…If tumor recurrence is a concern for clinicians, NSF reconstruction should be delayed until a pathological report is available to prevent delaying diagnosis because of flap coverage. In our previous work, we advocated for the use of a molecular method using Epstein-Barr virus latent membrane protein-1 as a genetic marker to differentiate NPC recurrence from ORN [ 7 ]. The method has been proven to be a good adjunct to pathological examination.…”

Section: Discussionmentioning

confidence: 99%

Using a nasoseptal flap for the reconstruction of osteoradionecrosis in nasopharyngeal carcinoma: A case report

Adel

Chang

2016

Journal of Otolaryngology - Head & Neck Surgery

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BackgroundOsteoradionecrosis (ORN) is a challenging complication in patients with postirradiated nasopharyngeal carcinoma (NPC). The aim of this study was to evaluate the usage of a nasoseptal flap (NSF) after endoscopic sequestrectomy to reconstruct resultant skull base defects for the treatment of ORN.Case PresentationWe present our experience on the adaption of an NSF as a reconstruction method for bony clival defects after endoscopic sequestrectomy in patients with postirradiated NPC. We propose that by which the patient may be offered better and prompt surgical results in the more adequate coverage of a vascularized flap for the exposed defect and attenuate the hypoxic and inflammatory process among the NPC patients suffering from postirradiation ORN.ConclusionsTo our knowledge, NSF use in such an indication has not been previously reported. Consequently, we advocate its utility for the management of patients with postirradiated skull base ORN in NPC in the future.

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Section: Discussionmentioning

confidence: 99%

Using a nasoseptal flap for the reconstruction of osteoradionecrosis in nasopharyngeal carcinoma: A case report

Adel

Chang

2016

Journal of Otolaryngology - Head & Neck Surgery

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“…It is also difficult to distinguish chronic nasopharyngitis and fibrosis from local recurrence. Postirradiated skull‐base osteoradionecrosis might also masquerade as local recurrence 9 . However, early detection of primary recurrence for NPC followed immediately by salvage therapy improves local control because the salvage therapy is very dependent on the extent of tumor 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Postirradiated skull-base osteoradionecrosis might also masquerade as local recurrence. 9 However, early detection of primary recurrence for NPC followed immediately by salvage therapy improves local control because the salvage therapy is very dependent on the extent of tumor. 2 Therefore, early detection followed by prompt treatment is the best way to improve survival.…”

Section: Discussionmentioning

confidence: 99%

Monitoring Tumor Recurrence with Nasopharyngeal Swab and Latent Membrane Protein‐1 and Epstein‐Barr Nuclear Antigen‐1 Gene Detection in Treated Patients with Nasopharyngeal Carcinoma

2004

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“…Expression of LMP-1 in nasopharyngeal swabs may be a valuable tool in screening for recurrences [48]. In this context, tyramid-enhanced LMP-1 immunostaining might help to distinguish tumor relapse from osteoradionecrosis [49] and to narrow diagnosis of primary tumor in CUP syndrome. Finally, it has recently been shown that antiviral agents like cidofovir could down-regulate LMP-1, which opens new horizons for a novel anticancer strategy in NPC [50].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Impact of EBV-Related LMP-1, Histologic Type, and Environmental Factors in Nasopharyngeal Carcinoma in a German Population

et al. 2004

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Introduction: This retrospective study addressed the possible involvement of latent Epstein-Barr virus (EBV) infection, in particular LMP-1 expression, and further exogenous factors, i.e. tobacco, alcohol and occupational hazardous substances, in nasopharyngeal carcinoma (NPC) in a German population. Patients and Methods: From 1980 to 2000, 44 patients suffering from histologically confirmed NPC were entered into the study. 33 specimens were available for immunostaining (IHC) to analyze LMP-1 expression. Information about environmental exposures were obtained employing a detailed standardized questionnaire. Results: Outcome of patients with squamous cell NPC (SC-NPC) was significant worse than that of those with non-keratinizing NPC (NK-NPC). Age and tumor size correlated with response to therapy. The group with negative conventional LMP-1 staining showed better overall survival after 5 years compared to the group with positive or marginally positive LMP-1 detection (not significant). Nevertheless, after staining by tyramid- augmented IHC (TSA-IHC), nearly all specimens with negative LMP-1-staining in conventional IHC were found to be clearly positive. All patients with SC-NPC were smokers. The distribution of smokers and non-smokers in the group of NK-NPC was balanced. Comparable to the tobacco observation, there was also a correlation between high alcohol consumption and SC-NPC. Conclusion: Prognosis of NPC is mainly dependent on histologic type. Prognostic impact of LMP-1 is still unclear since LMP-1 was detected in all specimens using TSA-IHC. Therefore, TSA-IHC-LMP-1 detection might be interesting for diagnostic specification and development of new therapeutic strategies in NPC.

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Differentiation of Recurrent Nasopharyngeal Carcinoma and Skull Base Osteoradionecrosis by Epstein‐Barr Virus‐Derived Latent Membrane Protein‐1 Gene

Abstract: The LMP-1 gene is a potential marker to differentiate between recurrent NPC and ORN. The presence of the LMP-1 gene in patients with ORN may indicate local recurrence.

Cited by 15 publications

References 14 publications

Using a nasoseptal flap for the reconstruction of osteoradionecrosis in nasopharyngeal carcinoma: A case report

Using a nasoseptal flap for the reconstruction of osteoradionecrosis in nasopharyngeal carcinoma: A case report

Monitoring Tumor Recurrence with Nasopharyngeal Swab and Latent Membrane Protein‐1 and Epstein‐Barr Nuclear Antigen‐1 Gene Detection in Treated Patients with Nasopharyngeal Carcinoma

Prognostic Impact of EBV-Related LMP-1, Histologic Type, and Environmental Factors in Nasopharyngeal Carcinoma in a German Population

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