Differentiation of Yin, Yang and Stasis Syndromes in Severe Aplastic Anemia Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation and Their Correlation with Iron Metabolism, cAMP/cGMP, 17-OH-CS and Thyroxine

Hu, Huijin; Chen, Tao; Liu, Wenbin; Shen, Yueqian; Li, Qiushuang; Zhou, Yuhong; Ye, Baodong; Wu, Dijiong

doi:10.2147/jbm.s332171

Cited by 3 publications

(3 citation statements)

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“…It has been reported that BUSHEN HUOXUE decoction could reduce the expression of IL-6 [ 18 ], which might affect the stability of the hematopoietic microenvironment in bone marrow [ 43 ]. In addition, about 61% of patients with AA were complicated by syndromes of “blood stasis” [ 19 ]. In this study, the “Danggui-Jixueteng” combo showed the highest statistical support in association rule analysis, which may indicate that dispelling blood stasis is as important as tonifying the kidneys in treating AA.…”

Section: Discussionmentioning

confidence: 99%

“…The name “aplastic anemia” does not appear in the ancient Chinese classics, whose clinical manifestations tend to be “consumptive disease” or “hemorrhagic syndrome” in traditional Chinese concepts [ 18 ]. In the 1950s, AA was thought to be a deficiency of Qi and blood according to the clinical manifestations of the patients [ 19 ]. In the 1960s, on the basis of the syndrome differentiation of Qi and blood, the effects of Guipi Decoction and Bazhen Decoction were poor [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Medication Regularity of Traditional Chinese Medicine in the Treatment of Aplastic Anemia Based on Data Mining

Dong

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Aplastic anemia (AA) is an uncommon disease, characterized by pancytopenia and hypocellular bone marrow, but it is common in the blood system. The medication rules of traditional Chinese medicine (TCM) in the treatment of AA are not clear, for which it is worth exploring the medication rules by data mining methods. Methods. This study used SPSS Modeler 18.0 and SPSS statistics to analyze the cases of AA from Zhejiang Provincial Hospital of Chinese Medicine (ZJHCM) from March 1, 2019, to March 1, 2022. Data mining methods, including frequency analysis, cluster analysis, and association rule learning, were performed in order to explore the medication rules for AA. Results. (1) A total of 859 prescriptions, which met the inclusion criteria, consisted of 255 herbs. In descending order of the frequency of herbal medicine, we have Danggui, Huangqi, Shudihuang, Fuling, Gancao, Shanyao, Shanzhuyu, Baizhu, Dangshen, and Xianhecao. (2) Frequency analysis of herb properties: the Four Qi of 255 kinds of TCMs are mainly warm and neutral medicines. The Five Flavors are mainly sweet medicines, followed by bitter medicines. The main meridians are the liver, spleen, and kidney. (3) Clustering of medications: TCMs with the top 20 frequencies are classified into 9 groups by cluster analysis. (4) Association rule analysis of high-frequency herbs: using the Apriori algorithm, the results showed that there were 3 herb pairs with support of over 0.3 and 12 herb pairs with confidence above 0.85. Conclusion. The basic pathogenesis of AA (Sui Lao) is spleen and kidney essence deficiency, Qi deficiency, and blood stasis. The main herbs have warm and neutral properties, sweet tastes, and liver, spleen, and kidney meridian tropisms, whose purpose is to tonify the kidney and invigorate the spleen, tonify Qi, and promote blood circulation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Medication Regularity of Traditional Chinese Medicine in the Treatment of Aplastic Anemia Based on Data Mining

Dong

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…First, in order to further explore the clinical problems and simulate clinical symptoms, our study effected a hydrocortisone-induced Yang deficiency and a thyroxine-induced Yin deficiency model in rats, with the relevant modeling methods having certain recognition in syndrome animal modeling under TCM theoretical guidelines ( Yao et al, 2007 ; Han et al, 2013 ; Ling and Xu, 2013 ; Reheman et al, 2019 ; Hu et al, 2021 ). Notably, the overall characterization, involving the general state, body weight, body temperature, and organ coefficients, in combination with the levels of T3 and TSH in serum, cAMP/cGMP in plasma, and glucose and lipid metabolism were comprehensively evaluated in our experiments.…”

Section: Discussionmentioning

confidence: 99%

Potential cardiotoxicity induced by Euodiae Fructus: In vivo and in vitro experiments and untargeted metabolomics research

Zhang

Lü²,

Ren³

et al. 2022

Front. Pharmacol.

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Background: Euodiae Fructus, a well-known herbal medicine, is widely used in Asia and has also gained in popularity in Western countries over the last decades. It has known side effects, which have been observed in clinical settings, but few studies have reported on its cardiotoxicity.Methods: In the present study, experiments using techniques of untargeted metabolomics clarify the hazardous effects of Euodiae Fructus on cardiac function and metabolism in rats in situations of overdosage and unsuitable syndrome differentiation. In vitro assays are conducted to observe the toxic effects of evodiamine and rutaecarpine, two main chemical constituents of Euodiae Fructus, in H9c2 and neonatal rat cardiomyocytes (NRCMs), with their signaling mechanisms analyzed accordingly.Results: The cardiac cytotoxicity of evodiamine and rutaecarpine in in vivo experiments is associated with remarkable alterations in lactate dehydrogenase, creatine kinase, and mitochondrial membrane potential; also with increased intensity of calcium fluorescence, decreased protein expression of the cGMP-PKG pathway in H9c2 cells, and frequency of spontaneous beat in NRCMs. Additionally, the results in rats with Yin deficiency receiving a high-dosage of Euodiae Fructus suggest obvious cardiac physiological dysfunction, abnormal electrocardiogram, pathological injuries, and decreased expression of PKG protein. At the level of endogenous metabolites, the cardiac side effects of overdose and irrational usage of Euodiae Fructus relate to 34 differential metabolites and 10 metabolic pathways involving among others, the purine metabolism, the glycerophospholipid metabolism, the glycerolipid metabolism, and the sphingolipid metabolism.Conclusion: These findings shed new light on the cardiotoxicity induced by Euodiae Fructus, which might be associated with overdose and unsuitable syndrome differentiation, that comes from modulating the cGMP-PKG pathway and disturbing the metabolic pathways of purine, lipid, and amino acid. Continuing research is needed to ensure pharmacovigilance for the safe administration of Chinese herbs in the future.

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Energy metabolism, immune function, and intestinal flora in rats with kidney-yin deficiency treated with raw or saltwater-processed Phellodendron chinense Schneid

Ren,

Zhao,

et al. 2024

Journal of Traditional Chinese Medical Sciences

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Differentiation of Yin, Yang and Stasis Syndromes in Severe Aplastic Anemia Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation and Their Correlation with Iron Metabolism, cAMP/cGMP, 17-OH-CS and Thyroxine

Cited by 3 publications

References 28 publications

Medication Regularity of Traditional Chinese Medicine in the Treatment of Aplastic Anemia Based on Data Mining

Medication Regularity of Traditional Chinese Medicine in the Treatment of Aplastic Anemia Based on Data Mining

Potential cardiotoxicity induced by Euodiae Fructus: In vivo and in vitro experiments and untargeted metabolomics research

Energy metabolism, immune function, and intestinal flora in rats with kidney-yin deficiency treated with raw or saltwater-processed Phellodendron chinense Schneid

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