Differing Relationship of Psycho-Social Variables with Active Ulcerative Colitis or Crohn’s Disease

Sarid, Orly; Slonim‐Nevo, Vered; Schwartz, Doron; Friger, Michael; Sergienko, Ruslan; Pereg, Avihu; Vardi, Hillel; Chernin, Elena; Singer, Terri; Greenberg, Dan; Odes, Shmuel

doi:10.1007/s12529-018-9712-5

Cited by 18 publications

(17 citation statements)

References 33 publications

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“…Although we found a high prevalence of anxiety symptoms in the current sample (see Table 1 and [31]), the presence of anxiety symptoms as such may not have to impact the HRQOL of youth with CD. In children and adolescents, the available studies did not show evidence for differences between CD and UC [23], but Sarid et al [51] showed worse psychosocial outcomes in patients with UC [27, 52]. Thirdly, anxiety and depression are highly comorbid, have overlapping symptoms, and anxiety is considered a precursor of depression [53, 54].…”

Section: Discussionmentioning

confidence: 99%

Illness Perceptions and Depression Are Associated with Health-Related Quality of Life in Youth with Inflammatory Bowel Disease

et al. 2019

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Background In youth with inflammatory bowel disease (IBD), health-related quality of life (HRQOL) has been shown to be affected by individual disease factors and specific psychological factors. The innovative aim of this study is to examine the combined impact of psychological factors (illness perceptions, cognitive coping, anxiety, and depression) on HRQOL, over and above the associations of demographic and disease factors with HRQOL in youth with IBD. Method Data on clinical disease activity, illness perceptions, cognitive coping, anxiety, depression, and HRQOL were prospectively collected in 262 consecutive youth (age 10–20, 46.6% male) with confirmed IBD. Multiple linear regression analyses tested the associations of demographic, disease, and psychological variables with HRQOL in separate groups for Crohn’s disease (CD; N = 147) and ulcerative colitis and IBD unclassified (UC/IBD-U; N = 115), using age-specific validated instruments. Results In both disease groups, more negative illness perceptions (ß = − .412; ß = − .438, p < .001) and more depression (ß = − .454; ß = − .279, p < .001) were related to lower HRQOL. In the UC/IBD-U group, more anxiety was related to lower HRQOL (ß = − .201, p = .001). The model with the psychological variables explained a large and significant amount of variance in both groups: 74% and 83%, respectively (p < .001). Conclusion In 10–20-year-old IBD patients, negative illness perceptions and depression were significantly and more strongly associated with lower HRQOL than demographic and disease factors. Thus, it is important to integrate psychological factors in the treatment for IBD patients. To improve HRQOL in young IBD patients, psychological interventions should be targeted at negative illness perceptions and depression.

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Section: Discussionmentioning

confidence: 99%

Illness Perceptions and Depression Are Associated with Health-Related Quality of Life in Youth with Inflammatory Bowel Disease

et al. 2019

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“…Some medical therapies are effective in both diseases; other therapies work well in one, but not the other 21 . There is also evidence of different prevalence of affective symptoms and different strategies of coping with psychosocial stress 22,23 . In this regard, a study using near infrared spectroscopy (NIRS) provided preliminary evidence for neural differences between CD and UC in terms of a decreased activity in the frontal lobe of UC patients compared to CD, 24 but topologically more distinct evidence, such as high‐resolution MRI data, is lacking.…”

Section: Introductionmentioning

confidence: 99%

Exploring joint patterns of brain structure and function in inflammatory bowel diseases using multimodal data fusion

Thomann

Schmitgen

Kmuche

et al. 2020

Neurogastroenterology Motil

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“…In addition, poor mental health has been consistently associated with disease severity among patients with IBD (Byrne et al, 2017; Graff et al, 2009; Neuendorf et al, 2016; Rochelle and Fidler, 2013; Trindade et al, 2016). For example, a recent study found that the link between stressful life events and worse Crohn’s disease activity was mediated by psychological distress (Sarid et al, 2018). Some studies suggested that psychological distress may represent a consequence of disease activity (Kurina et al, 2001), whereas others argued that psychological distress increases likelihood of disease relapse (Mittermaier et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Differential relationships of somatization, depression, and anxiety to severity of Crohn’s disease

et al. 2020

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Patients with Crohn’s disease, an inflammatory bowel disease, struggle with chronic somatic symptoms that could bring about emotional distress. This study assessed the relative role of somatization, and depressive and anxiety symptoms in disease activity among 619 Crohn’s patients (18–79 years; 58.3% women). Structural equation modeling revealed that somatization was the only unique predictor of disease activity beyond depression and anxiety. In addition, the effect of somatization on disease activity was stronger in men compared to women. Findings suggest that somatization represents a distinct domain of psychological distress that may play a role in the health of patients with Crohn’s disease.

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Differing Relationship of Psycho-Social Variables with Active Ulcerative Colitis or Crohn’s Disease

Abstract: The impact of psycho-social variables on the active disease state differs between UC and CD, thus indicating a need for specifically tailored psychotherapies.

Cited by 18 publications

References 33 publications

Illness Perceptions and Depression Are Associated with Health-Related Quality of Life in Youth with Inflammatory Bowel Disease

Illness Perceptions and Depression Are Associated with Health-Related Quality of Life in Youth with Inflammatory Bowel Disease

Exploring joint patterns of brain structure and function in inflammatory bowel diseases using multimodal data fusion

Differential relationships of somatization, depression, and anxiety to severity of Crohn’s disease

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