DIFFICULT-TO-TREAT PEDIATRIC OBSESSIVE-COMPULSIVE DISORDER: FEASIBILITY AND PRELIMINARY RESULTS OF A RANDOMIZED PILOT TRIAL OF<scp>d</scp>-CYCLOSERINE-AUGMENTED BEHAVIOR THERAPY

Farrell, Lara J.; Waters, Allison M.; Boschen, Mark Justin; Hattingh, Laetitia; McConnell, Harry; Milliner, Ella Lindsey; Collings, Nigel; Zimmer‐Gembeck, Melanie J.; Shelton, Doug; Ollendick, Thomas H.; Testa, Chris; Storch, Eric A.

doi:10.1002/da.22132

Cited by 87 publications

(71 citation statements)

References 38 publications

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“…The only published DCS studies have involved children and adolescents with obsessive-compulsive disorder (Storch et al 2010;Farrell et al 2013). Storch and colleagues randomized 30 8-17-year-old youth to either CBT and DCS or CBT and placebo for seven exposure sessions.…”

Section: Dcs As An Adjunct To Psychotherapy For Ptsdmentioning

confidence: 99%

Randomized Placebo-Controlled D-Cycloserine with Cognitive Behavior Therapy for Pediatric Posttraumatic Stress

Scheeringa

Weems

2014

Journal of Child and Adolescent Psychopharmacology

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This initial study of CBT and DCS to treat pediatric PTSD provided suggestive and preliminary evidence for more rapid symptom recovery and beneficial effects on attention, but did not show an overall greater effect for reducing PTSD symptoms. It appears that augmentation with DCS represents unique challenges in PTSD. Because PTSD involves complex, life-threatening trauma memories, as opposed to the imagined dreadful outcomes of other anxiety disorders, the use of DCS may require greater attention to how its use is coupled with exposure-based techniques. DCS may have inadvertently enhanced reconsolidation of trauma memories rather than more positive and adaptive memories. In addition, the results suggest that future research could focus on the longer-term benefits of DCS on attention and ways to capitalize on attention-enhancing therapies. ClinicalTrials.gov registry: Effect of D-cycloserine on Treatment of Posttraumatic Stress Disorder (PTSD) in Youth, #NCT01157416, http://clinicaltrials.gov/ct2/results?term=NCT01157416&Search=Search , and D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents, #NCT01157429, http://clinicaltrials.gov/ct2/results?term=NCT01157429&Search=Search .

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Section: Dcs As An Adjunct To Psychotherapy For Ptsdmentioning

confidence: 99%

Randomized Placebo-Controlled D-Cycloserine with Cognitive Behavior Therapy for Pediatric Posttraumatic Stress

Scheeringa

Weems

2014

Journal of Child and Adolescent Psychopharmacology

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“…Behavioural treatments for OCD have been repeatedly demonstrated to be effective (Rosa-Alcázar, Sánchez-Meca, Gómez-Conesa, & Marín=Martínez, 2008), even in the most severe and refractory cases Boschen, Drummond, & Pillay, 2008;Farrell et al, 2013). Despite this success, increasing research interest (Boschen, 2008), and applications of technological advances to the treatment of OCD (Lind, Boschen, & Morrissey, 2013), there are many for whom treatment is ineffective (Fisher & Wells, 2005), and predictors of treatment response have been difficult to identify (Boschen, Drummond, Pillay, & Morton, 2010;Boschen & Farrell, 2011).…”

mentioning

confidence: 99%

Effective behavioural strategies for reducing disgust in contamination-related OCD: A review

Ludvik

Boschen

Neumann

2015

Clinical Psychology Review

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“…Results of this study showed DCS-augmented exposure, and response prevention produced significant improvements in OCD severity relative to a placebo control in severe and difficult-to-treat pediatric OCD [113]. Lamotrigine is an antiepileptic drug and also a mood stabilizer that decreases extreme glutamate release [114,115].…”

Section: Medical Treatmentmentioning

confidence: 90%

Cognitive-Behavioral Therapy of Obsessive-Compulsive Disorder in Children and Adolescents

Çimen¹

2018

Cognitive Behavioral Therapy and Clinical Applications

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While obsessive-compulsive disorder (OCD) is present under the category of anxiety disorders in DSM-IV TR, it is classified under "Obsessive Compulsive Disorder and Related Disorders" in DSM 5. There is no different diagnostic system for children and adolescents. OCD has serious adverse effects on family, school, and social lives of children and adolescents, but adolescents with OCD often hide their symptoms and delay seeking help due to several reasons such as inability to recognize their symptoms as disease manifestations, embarrassment, fear of being stigmatized by other people, and believing that what the experience is transient. The age of onset has significance in terms of the disease progression. Therefore it is very important to detect OCD at its early stage, because the majority of the adult patients develop the disease during childhood or adolescence.

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DIFFICULT-TO-TREAT PEDIATRIC OBSESSIVE-COMPULSIVE DISORDER: FEASIBILITY AND PRELIMINARY RESULTS OF A RANDOMIZED PILOT TRIAL OFd-CYCLOSERINE-AUGMENTED BEHAVIOR THERAPY

Cited by 87 publications

References 38 publications

Randomized Placebo-Controlled D-Cycloserine with Cognitive Behavior Therapy for Pediatric Posttraumatic Stress

Randomized Placebo-Controlled D-Cycloserine with Cognitive Behavior Therapy for Pediatric Posttraumatic Stress

Effective behavioural strategies for reducing disgust in contamination-related OCD: A review

Cognitive-Behavioral Therapy of Obsessive-Compulsive Disorder in Children and Adolescents

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