Diffuse Cutaneous Reticulohistiocytosis

Proliferating multicentric reticulohistiocytosis associated with papillary serous carcinoma of the endometrium

“…8 Several patterns emerge in the temporal relationship between MRH and malignancy as reported in the English-language literature (Table I). In most cases, the onset of malignancy and MRH occurred within about 2 years of each other, [9][10][11][12][13][14][15][16] or the presentation of MRH prompted a workup and subsequent detection of malignancy. [17][18][19][20][21][22] However, the onset of MRH may also occur closer to the time of recurrence or metastasis of a previously diagnosed and treated malignancy.…”

Multiple cutaneous reticulohistiocytosis with T‐cell large granular lymphocyte clonopathy

“…Reticulohistiocytosis is a rare, non‐Langerhans histiocytic disorder of unknown aetiology. It comprises a disease spectrum that ranges from purely cutaneous ‘benign’ forms; namely, solitary cutaneous reticulohistiocytoma and multiple cutaneous reticulohistiocytosis (MCR), to the more aggressive form of multicentric reticulohistiocytosis (MR) with systemic involvement (arthropathy or visceral) and concomitant cutaneous lesions . Malignancy has been regarded as an underlying cause in about a quarter of patients with MR, but has not been reported in MCR .…”

Multicentric reticulohistiocytosis and urologic carcinomas: a possible paraneoplastic association

“…MR was initially described in 1954. It is now considered a form of histiocytosis that is characterized by papulonodular cutaneous lesions and destructive, deforming, symmetrical arthritis 1–3 . Lesions of the skin have a predilection for the hands with a characteristic periungual ‘coral‐bead’ appearance.…”