Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (<scp>DIPNECH</scp>): Prevalence, clinicopathological characteristics and survival outcome in a cohort of 311 patients with well‐differentiated lung neuroendocrine tumours

Hayes, Aimee R.; Luong, Tu Vinh; Banks, Jamie; Shah, Heer; Watkins, Jennifer; Lim, Eric; Patel, Anant; Grossman, Ashley; Krell, Daniel; Caplin, Martyn

doi:10.1111/jne.13184

Cited by 10 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In association with neuroendocrine cell proliferations, bronchiolar fibrosis with luminal narrowing or constrictive bronchiolitis are present. Single or multiple carcinoids may also be present, 16 strongly supporting the notion that the spectrum of neuroendocrine cell lesions, from neuroendocrine cell hyperplasia to carcinoids, represent a multistep model of progression. The clinical impact of DIPNECH in association with carcinoids is controversial, although some data suggest that multifocal pulmonary neuroendocrine proliferations represent a relevant adverse prognostic factor in carcinoid tumours, being associated with a higher risk of lymph node spread and tumour relapse 17 .…”

Section: Non‐neoplastic Conditions and Pre‐invasive Neuroendocrine Le...mentioning

confidence: 57%

Updates on lung neuroendocrine neoplasm classification

Vocino Trucco,

Righi,

Volante

et al. 2023

Histopathology

View full text Add to dashboard Cite

Lung neuroendocrine neoplasms (NENs) are a heterogeneous group of pulmonary neoplasms showing different morphological patterns and clinical and biological characteristics. The World Health Organisation (WHO) classification of lung NENs has been recently updated as part of the broader attempt to uniform the classification of NENs. This much‐needed update has come at a time when insights from seminal molecular characterisation studies revolutionised our understanding of the biological and pathological architecture of lung NENs, paving the way for the development of novel diagnostic techniques, prognostic factors and therapeutic approaches. In this challenging and rapidly evolving landscape, the relevance of the 2021 WHO classification has been recently questioned, particularly in terms of its morphology‐orientated approach and its prognostic implications. Here, we provide a state‐of‐the‐art review on the contemporary understanding of pulmonary NEN morphology and the potential contribution of artificial intelligence, the advances in NEN molecular profiling with their impact on the classification system and, finally, the key current and upcoming prognostic factors.

show abstract

Section: Non‐neoplastic Conditions and Pre‐invasive Neuroendocrine Le...mentioning

confidence: 57%

Updates on lung neuroendocrine neoplasm classification

Vocino Trucco,

Righi,

Volante

et al. 2023

Histopathology

View full text Add to dashboard Cite

show abstract

“…6) occurs in 20% of patients with NETs and has a female predominance (19:1). 27 However, it is extremely rare for tumorlets to metastasize. 28 Both tumorlets and DIPNECH are also associated with mutations in MEN1 (Table 2).…”

Section: Neuroendocrine Neoplasms Of the Lungmentioning

confidence: 99%

“…Conversely, DIPNECH (Fig. 6) occurs in 20% of patients with NETs and has a female predominance (19:1) 27 . However, it is extremely rare for tumorlets to metastasize 28 .…”

Section: Classification Of Nens With a Focus On The Updated 2019 Who ...mentioning

confidence: 99%

An Illustrated Review of the Recent 2019 World Health Organization Classification of Neuroendocrine Neoplasms: A Radiologic and Pathologic Correlation

Ursprung,

Zhang,

Asmundo

et al. 2024

J Comput Assist Tomogr

View full text Add to dashboard Cite

Recent advances in molecular pathology and an improved understanding of the etiology of neuroendocrine neoplasms (NENs) have given rise to an updated World Health Organization classification. Since gastroenteropancreatic NENs (GEP-NENs) are the most common forms of NENs and their incidence has been increasing constantly, they will be the focus of our attention. Here, we review the findings at the foundation of the new classification system, discuss how it impacts imaging research and radiological practice, and illustrate typical and atypical imaging and pathological findings. Gastroenteropancreatic NENs have a highly variable clinical course, which existing classification schemes based on proliferation rate were unable to fully capture. While well- and poorly differentiated NENs both express neuroendocrine markers, they are fundamentally different diseases, which may show similar proliferation rates. Genetic alterations specific to well-differentiated neuroendocrine tumors graded 1 to 3 and poorly differentiated neuroendocrine cancers of small cell and large-cell subtype have been identified. The new tumor classification places new demands and creates opportunities for radiologists to continue providing the clinically most relevant report and on researchers to design projects, which continue to be clinically applicable.

show abstract

The Driver Role of Pathologists in Endocrine Oncology: What Clinicians Seek in Pathology Reports

et al. 2023

View full text Add to dashboard Cite

Endocrine neoplasia represents an increasingly broad spectrum of disorders. Endocrine neoplasms range from incidental findings to potentially lethal malignancies. In this paper, we cover the impact of pathology in the interpretation of the clinic-pathological, genetic, and radiographic features underpinning these neoplasms. We highlight the critical role of multidisciplinary interactions in structuring a rational diagnostic and efficient therapeutic plan and emphasize the role of histopathological input in decision-making. In this context, standardized pathology reporting and second opinion endocrine pathology review represent relevant tools to improve the overall diagnostic workup of patients affected by endocrine tumors in every specific scenario. In fact, although a relevant proportion of cases may be correctly identified based on clinical presentation and biochemical/imaging investigations, a subset of cases presents with atypical findings that may lead to an inappropriate diagnosis and treatment plan based on a wrong pathological diagnosis if all pieces of the puzzle are not correctly considered. Pathologists have a responsibility to actively guide clinicians before and during surgical procedures to prevent unnecessary interventions. In all areas of endocrine pathology, pathologists must understand the complexity of tissue preservation and assay sensitivities and specificities to ensure the optimal quality and interpretation of diagnostic material. Finally, pathologists are central actors in tumor tissue biobanking, which is an expanding field in oncology that should be promoted while adhering to strict ethical and methodological standards.

show abstract

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH): Prevalence, clinicopathological characteristics and survival outcome in a cohort of 311 patients with well‐differentiated lung neuroendocrine tumours

Cited by 10 publications

References 31 publications

Updates on lung neuroendocrine neoplasm classification

Updates on lung neuroendocrine neoplasm classification

An Illustrated Review of the Recent 2019 World Health Organization Classification of Neuroendocrine Neoplasms: A Radiologic and Pathologic Correlation

The Driver Role of Pathologists in Endocrine Oncology: What Clinicians Seek in Pathology Reports

Contact Info

Product

Resources

About