Diffuse large B-cell lymphoma: The history, current view and new perspectives

Abstract

The basic principles of lymphoma classification(s) in general have been widely evolving in a course of decades of years wiht the use of contemporary resources and recent cutting edges in hematooncology on a clinical, morphological and molecular level bring new possibilities not only in improvements of diagnostic and prognostic algorithms and also bear new opportunities in so called targeted and tailored strategies of lymphoma therapy. The pathogenesis and biologic behavior of lymphoproliferations and even lymphomas should be studied in a context of lymphocytic and (neoplastic) lymphoid stage and chronologic development. In a current more complex insight into lymphoproliferations we would like to describe huge heterogeneity of diffuse large B-cell lymphoma in relationship to mandatory WHO classification since 2008 and the next development of knowledge in this field with potential new influence on an advancement of both classification and therapy.

miR-28 regulates the germinal center reaction and blocks tumor growth in preclinical models of non-Hodgkin lymphoma

“…This is particularly relevant for BL and DLBCL, which are often refractory to conventional chemotherapy. 50,51 Taken together, the results of this study reveal the therapeutic potential of miR-28 and provide a rationale for the initiation of clinical trials of miR-28-based therapies to treat B-cell NHL.…”

A Novel Non-Immunoglobulin (non-Ig)/BCL6 Translocation in Diffuse Large B-Cell Lymphoma Involving Chromosome 10q11.21 Loci and Review on Clinical Consequences of BCL6 Rearrangements

“…In the lymph node, karyotype 79-88, XXY,-Y,−1,−3,−6,−7,−9, −14,−15,−22[cp5]/46,XY [5] was confirmed. In the bone marrow, only normal karyotypes were found (46,XY [10]).…”

“…BCL6 gene rearrangements belong to the most common aberrations observed in DLBCL [3][4][5][6][7]73]. Most frequently, the BCL6 gene is frequently involved in reciprocal translocations with IgH gene and rarely also with IgL and IgK genes [11][12][13].…”

“…This malignancy is characterized by wide variability in clinical outcome and high genetic heterogeneity [1,2]. The most common chromosomal abnormality in DLBCL is a 3q27 translocation affecting BCL6 gene, occurring in up to 45 % of patients [3][4][5][6].…”

“…This zinc-finger transcription factor functions as a sequence-specific transcriptional repressor [8][9][10]. BCL6 is commonly translocated in DLBCL with diverse partners, including one of three immunoglobulin gene (IGH, IGK, IGL) loci [11][12][13] or diverse non-Ig chromosomal loci [3,5,6,14]. The translocations affecting the BCL6 gene occur in DLBCL Marie Jarosova and Eva Kriegova contributed equally to this work.…”