Diffuse mesothelioma of the peritoneum: correlation between histological and clinical parameters and survival in 73 patients

A man aged 79 years with a history of malignant peritoneal mesothelioma presented 8 years after primary presentation with a suspected right-sided painful inguinal hernia and hydrocele, both present for 5 months. During surgery, however, the inguinal swelling appeared to be a tumour. Laboratory examination was non-alarming and ultrasonography not specific for mesothelioma. Pathological examination showed it to be a recurrence of the malignant mesothelioma, which was treated palliative with radiotherapy. This clinical picture is rare and a recurrence-free survival of 8 years is remarkable.

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“…Liu et al 10 studied survival of peritoneal mesotheliomas. In the literature, peritoneal mesothelioma is divided into benign and malignant.…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of a late-onset recurrence of malignant peritoneal mesothelioma

et al. 2017

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“…Epithelioid mesotheliomas are morphologically heterogeneous tumours, with many patterns having been described in the literature and included in the WHO classification . Most of the published studies focused on the prognostic significance of major types of peritoneal or pleural mesothelioma: epithelioid, sarcomatoid and biphasic types . Little is known about the prognostic significance of various morphological growth patterns of epithelioid mesotheliomas.…”

Section: Discussionmentioning

confidence: 99%

“…For pleural mesotheliomas, the epithelioid type is the most common and carries the best prognosis, whereas the sarcomatoid type has the worst prognosis . Interestingly, sarcomatoid and biphasic tumours in the peritoneum are less common, and they also have a worse prognosis than the epithelioid growth pattern …”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of morphological growth patterns and mitotic index of epithelioid malignant peritoneal mesothelioma

et al. 2015

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“…Both of these subtypes have a significantly worse prognosis, similar to the corresponding pleural mesothelioma variants (21,(41)(42)(43)(44). In one study, the median survival of patients with epithelioid subtypes of MPM was 55 months compared to 13 months for the biphasic subtype (45).…”

Section: Histology/pathologymentioning

confidence: 99%

Malignant peritoneal mesothelioma: a review

2017

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Mesothelioma is a malignancy of serosal membranes. It is most commonly encountered in the visceral pleura with the second most common location in the peritoneum. The diagnosis is very rare and has been linked to toxic exposure to industrial pollutants, especially asbestos. Malignant peritoneal mesothelioma (MPM) commonly presents with diffuse, extensive spread throughout the abdomen with rare metastatic spread beyond the abdominal cavity. Due to its rarity and nonspecific symptoms, it is usually diagnosed late when the disease burden is extensive. Because pleural mesothelioma is more common than MPM, most research has been on the pleural variant and extrapolated for MPM. While treatment advances have been made for MPM, the disease is universally fatal from either abdominal complications secondary to the spread of disease or starvation.Untreated, the life expectancy is less than a year. Cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC) has become the mainstay of therapy with systemic therapies still being developed. We will review the epidemiology of MPM and discuss diagnostic and treatment strategies.

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Diffuse mesothelioma of the peritoneum: correlation between histological and clinical parameters and survival in 73 patients

Cited by 65 publications

References 22 publications

Unusual presentation of a late-onset recurrence of malignant peritoneal mesothelioma

Unusual presentation of a late-onset recurrence of malignant peritoneal mesothelioma

Prognostic significance of morphological growth patterns and mitotic index of epithelioid malignant peritoneal mesothelioma

Malignant peritoneal mesothelioma: a review

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