1984
DOI: 10.1016/0002-9149(84)90464-8
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Diffuse or segmental narrowing (spasm) of the coronary arteries during smoking demonstrated on angiography

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Cited by 67 publications
(7 citation statements)
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“…Several studies have shown that chronic smokers have an increased risk of cardiovascular disease, such as atherosclerosis, coronary heart disease, and sudden death. In addition, smoking causes endothelial dysfunction, a decrease in coronary reserve, and vasospasms [3][4][5] .…”
mentioning
confidence: 99%
“…Several studies have shown that chronic smokers have an increased risk of cardiovascular disease, such as atherosclerosis, coronary heart disease, and sudden death. In addition, smoking causes endothelial dysfunction, a decrease in coronary reserve, and vasospasms [3][4][5] .…”
mentioning
confidence: 99%
“…Acute effects of nicotine include increase in myocardial oxygen demand, coronary vascular tone mediators, increasing the heart rate, and systemic blood pressure but decreasing the coronary blood flow and coronary flow reserve (17). Acute cigarette consumption temporarily reduces nitrate, nitrite and concentrations of antioxidants in plasma that is associated with the high blood pressure and higher HR.…”
Section: Discussionmentioning
confidence: 99%
“…Ischemia occurring during routine daily activities, identified by AECG monitoring, typically occurs at a heart rate 10-20% lower than the heart rate at which ischemia develops during an ETT, 6 and the heart rate threshold at which ischemia occurs varies substantially, 7,8 suggesting that varying degrees of coronary vasoconstriction play an important role in ambulatory ischemia. A variety of stimuli typically experienced during outpatient activities consistently provoke episodic coronary vasoconstriction in the laboratory: mental or emotional stress, 9,10 anger, 11 exercise, 12 cigarette smoking, 13 and exposure to cold. 14 Andrews et al 15 related the minute-by-minute heart rate profile of stable coronary patients to the episodes of daily life ischemia and found that only 20% of ischemic episodes occurred in the absence of a heart rate increase, which would be the case if vasoconstriction was the primary pathophysiologic mechanism, and that approximately 80% of ischemic episodes were preceded by an increase in heart rate.…”
Section: Significance Of Aecg Ischemia In the Coronary Syndromes Stabmentioning
confidence: 99%