1995
DOI: 10.1055/s-0038-1649993
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Diffuse Severe Digestive Angiodysplasia in Bernard-Soulier Syndrome

Abstract: mbH (Stuttgart) 74 (6) 1604-12 (1995) thereafter. They suggested that a condition of rebound hypercoagula bility could occur in these patients, especially one week after interrup tion when prothrombin complex factors are already back to normal values but factor VIII remains high. The recorded changes in factor VIII:C levels after anticoagulation withdrawal are not easy to explain. One possible, though as yet un proven, explanation of this decreasing trend during the first weeks may be a transient consumption/d… Show more

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Cited by 11 publications
(7 citation statements)
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“…There are several options for the management of bleeding gastrointestinal angiodysplasia, such as surgical resection, endoscopic therapy, and administration of estroprogesterons or octreotide [4,5,11]. Although varying degrees of success have been reported, none of those therapeutic apporoaches has been cited as a preferred treatment modality [3][4][5]14]. In the present case, surgery or endoscopic therapy was not considered to be appropriate since most of the stomach was affected by the vascular lesion.…”
Section: Discussionmentioning
confidence: 95%
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“…There are several options for the management of bleeding gastrointestinal angiodysplasia, such as surgical resection, endoscopic therapy, and administration of estroprogesterons or octreotide [4,5,11]. Although varying degrees of success have been reported, none of those therapeutic apporoaches has been cited as a preferred treatment modality [3][4][5]14]. In the present case, surgery or endoscopic therapy was not considered to be appropriate since most of the stomach was affected by the vascular lesion.…”
Section: Discussionmentioning
confidence: 95%
“…Although it occurs mostly as an occasional abnormality, it might be associated with a number of systemic diseases, including cirrhosis, chronic renal failure, scleroderma, aortic stenosis, and bleeding disorders such as congenital or acquired von Willebrand disease (vWd), inherited disorders of platelet function, thrombocytopenia, and factor X deficiency, as well [6][7][8][9][10][11][12]. Angiodysplasia has been reported in association with BSS in adult patients [3,4], but, to the best of our knowledge, this is the first pediatric case of angiodysplasia associated with BSS.…”
Section: Discussionmentioning
confidence: 99%
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“…The patient's history was marked by repeated nose bleeds and post-traumatic haemorrhages requiring multiple transfusions. These led to anti-human leucocyte antigen (HLA) and anti-platelet alloimmunization and the occurrence of hepatitis B and C. At the age of 50 years, he developed very diffuse, severe digestive angiodysplasia which improved under oestroprogestative therapy (Belluci et al, 1995). The patient died of ethmoidal cancer in 1997.…”
Section: Patient and Methodsmentioning
confidence: 99%