Diffuse Skeletal Muscles Uptake of [18F] Fluorodeoxyglucose on Positron Emission Tomography in Primary Muscle Peripheral T-cell Lymphoma

Tanaka, Yuji; Hayashi, Yuichi; Kato, Junichi; Yamada, Megumi; Koumura, Akihiro; Sakurai, Takeo; Kimura, Akio; Hozumi, Isao; Hatano, Yuichiro; Hirose, Yoshinobu; Takami, Taro; Nakamura, Hiroshi; Kasahara, Senji; Tsurumi, Hisashi; Moriwaki, Hisataka; Ishii, Takashi

doi:10.2169/internalmedicine.50.4992

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…PTCL‐NOS can also arise from other rare extranodal tissues, such as paratesticular soft tissue and liver . Moreover, there are three cases of primary PTCL‐NOS arising in muscle that were not associated with rhabdomyolysis .…”

Section: Discussionmentioning

confidence: 99%

Peripheral T‐cell lymphoma with unusual clinical presentation of rhabdomyolysis

Liu

Medeiros

Young

2015

Hematological Oncology

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Primary extranodal lymphoma is known to occur in nose, gastrointestinal tract, skin, bone, and central nervous system. However, it is extremely rare for primary lymphoma to arise in skeletal muscle. We report a case of a 32-year-old man who presented initially with fever and fatigue. He had a history of alcohol abuse. Laboratory studies and computerized tomography scan showed results consistent with rhabdomyolysis, but the cause of the rhabdomyolysis was undetermined. After biopsy of abdominal skeletal muscle with histologic examination and T-cell receptor gamma chain gene rearrangement analysis, the diagnosis of peripheral T-cell lymphoma was established. After two cycles of the cyclophosphamide, doxorubicin, vincristine, prednisone, and etoposide regimen, the patient's symptoms greatly improved. This is the third reported case of peripheral T-cell lymphoma arising in skeletal muscle reported in the literature and which presented clinically with rhabdomyolysis. The alcohol abuse during the clinical course likely worsens the pathologic process of the rhabdomyolysis.

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Section: Discussionmentioning

confidence: 99%

Peripheral T‐cell lymphoma with unusual clinical presentation of rhabdomyolysis

Liu

Medeiros

Young

2015

Hematological Oncology

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“…Primary skeletal muscle peripheral T-cell lymphoma, not otherwise specified (PSM-PTCL, NOS), are a group of rare and aggressive lymphomas, with only eight previous reports on the condition published (2)(3)(4)(5)(6)(7)(8)(9). Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is the most common subtype of mature aggressive T-cell lymphoma, manifesting most often as a nodal disease (10).…”

Section: Introductionmentioning

confidence: 99%

Primary Skeletal Muscle Peripheral T-cell Lymphoma: An Autopsy Case Report and Review of the Literature

et al. 2021

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Primary skeletal muscle lymphoma is extremely uncommon, and there have only been eight previous case reports on primary skeletal muscle peripheral T-cell lymphoma, not otherwise specified (PSM-PTCL, NOS). We herein report an autopsy case of a 71-year-old woman with PSM-PTCL, NOS, who had a 24-year history of systemic sclerosis treated with immunosuppressive drugs. A post-mortem examination revealed infiltration of lymphoma cells positive for T-cell markers, cytotoxic markers, and p53. This case was considered to be one of other iatrogenic immunodeficiency-associated lymphoproliferative disorder (OIIA-LPD). This is the first case categorized under both PSM-PTCL, NOS, and OIIA-LPD.

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“…2 On imaging, skeletal muscle lymphomas tend to involve multiple muscles with diffuse muscle enlargement, multicompartimental muscle involvement, homogeneous or inhomogeneous enhancement, and intense FDG uptake. [3][4][5][6][7][8][9] FAPI PET findings of skeletal muscle lymphoma are rarely reported. 10 FAPI PET is useful for detecting fibroblast activation protein expression in stromal cells of the lymphoma lesions.…”

mentioning

confidence: 99%

“…Primary skeletal muscle non-Hodgkin's lymphoma is very rare, accounting for only 0.1% of all lymphomas 2. On imaging, skeletal muscle lymphomas tend to involve multiple muscles with diffuse muscle enlargement, multicompartimental muscle involvement, homogeneous or inhomogeneous enhancement, and intense FDG uptake [3][4][5][6][7][8][9]. FAPI PET findings of skeletal muscle lymphoma are rarely reported 10.…”

mentioning

confidence: 99%

18F-FAPI-42 Versus 18F-FDG PET/MRI in a Case of Primary Peripheral T-Cell Lymphoma of the Skeletal Muscles

Ran,

Li,

et al. 2024

Clin Nucl Med

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Primary skeletal muscle lymphoma is rare. We describe 18F-FAPI-42 and 18F-FDG PET/MRI findings in a case of primary peripheral T-cell lymphoma of the skeletal muscles with brain involvement. The multiple skeletal muscle tumors and one larger cerebral tumor showed intense FDG uptake and mild to moderate FAPI uptake. FDG PET was superior to FAPI PET in delineating the muscle tumors because of significantly higher FDG uptake of the muscle tumors than FAPI uptake. FAPI PET was superior to FDG PET in delineating the cerebral lesion because of a very low background FAPI activity in the brain parenchyma.

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Diffuse Skeletal Muscles Uptake of [18F] Fluorodeoxyglucose on Positron Emission Tomography in Primary Muscle Peripheral T-cell Lymphoma

Cited by 6 publications

References 19 publications

Peripheral T‐cell lymphoma with unusual clinical presentation of rhabdomyolysis

Peripheral T‐cell lymphoma with unusual clinical presentation of rhabdomyolysis

Primary Skeletal Muscle Peripheral T-cell Lymphoma: An Autopsy Case Report and Review of the Literature

18F-FAPI-42 Versus 18F-FDG PET/MRI in a Case of Primary Peripheral T-Cell Lymphoma of the Skeletal Muscles

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