Diffusion Tensor Imaging Characteristics of the Corpus Callosum in Mild, Moderate, and Severe Traumatic Brain Injury

Abstract

BACKGROUND AND PURPOSE:The corpus callosum is an important predilection site for traumatic axonal injury but may be unevenly affected in head trauma. We hypothesized that there were local differences in axonal injury within the corpus callosum as investigated with diffusion tensor imaging (DTI), varying among patients with differing severity of traumatic brain injury (TBI).

Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury

“…In some cases, these white matter FA values were predictive of impaired executive functioning48 and were correlated with decreased behavioral outcomes 44, 49. The corpus callosum is among the most common locations of abnormal FA50, 51 and is thought to be particularly vulnerable to axonal injury resulting from TBI 52. As such, the reduced FA abnormalities in the corpus callosum found in this study would be expected and further support the clinical relevance of the ACHI model.…”

Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions

“…The clinical implications of FA change remain controversial, as both increased and decreased FA has been observed in concussion studies. [162][163][164][165][166] These discrepancies may be due, in part, to the considerable spatial heterogeneity in the brain areas examined, 167 as well as differences in the postinjury interval. FA may still have prognostic value, with evidence suggesting that the direction and magnitude of change correlates with clinical outcomes; 166,168 however, this idea awaits validation in both paediatric and adult populations.…”

Evaluation of Callosal Motor Fiber Location in the Human Brain by Diffusion Tensor Tractography Combined with Functional MRI

“…These studies investigated the thickness, volume, and area information of the CC to provide accurate anatomical information 9,10,25) . Moreover, studies have compared the distribution of the CC in both healthy and diseased individuals in order to provide information regarding anatomical changes in diseased individuals 1,11,26) . Although many studies have been performed so far, the anatomical location of CMFs in the CC is still a controversial topic.…”

“…Being the largest fiber bundle, it enables interconnection between the two cerebral hemispheres [1][2][3][4][5][6][7][8] . Previous studies have used magnetic resonance imaging (MRI) to determine several anatomical and morphological attributes of the CC, such as volume, gender difference, and handedness for the evaluation of changes between health and neurological disorders 1,4,6,[9][10][11][12] . The anatomical location and features of CC-related motor fibers, known as callosal motor fibers (CMFs), have been studied by many neurological researchers to assess and obtain more accurate characteristic information about the CC 2,7,[13][14][15] .…”

“…The anatomical location and features of CC-related motor fibers, known as callosal motor fibers (CMFs), have been studied by many neurological researchers to assess and obtain more accurate characteristic information about the CC 2,7,[13][14][15] . Through prior assessment of CMFs in the CC, it is known that CMFs primarily cross through the anterior midbody of the CC, as shown in rhesus monkeys by Pandya et al and Schmahmann et al 11,14) . However, Meyer et al found that CMFs cross through the posterior body and isthmus of the CC utilizing transcranial magnetic stimulation (TMS) measurements, and Hofer et al, Zarei et al, and Wahl et al made the same observations using diffusion tensor imaging (DTI) 2,7,8,13) .…”