Diffusion tensor imaging findings in young children with benign external hydrocephalus differ from the normal population

Sun, Miao; Yuan, Weihong; Hertzler, Dean A.; Cancelliere, Alessandro; Altaye, Mekibib; Mangano, Francesco T.

doi:10.1007/s00381-011-1651-2

Cited by 22 publications

(14 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, those with follow-up imaging detected no WM abnormalities without need of surgical intervention. 37 More recently we reported preliminary findings suggesting a correlation between abnormal DTI values and motor deficits in a prospectively studied patient population (a subset of the patients in the present study at pre-operative stage 44 ). Other groups have also reported that DTI parameters are sensitive in the study of hydrocephalus and suggest that DTI could serve as an important tool for quantitative assessment.…”

Section: Discussionmentioning

confidence: 50%

Diffusion tensor imaging study of pediatric patients with congenital hydrocephalus: 1-year postsurgical outcomes

Mangano

Altaye

McKinstry

et al. 2016

PED

View full text Add to dashboard Cite

OBJECTIVE The purpose of this study was to investigate white matter (WM) structural abnormalities using diffusion tensor imaging (DTI) in children with hydrocephalus before CSF diversionary surgery (including ventriculoperitoneal shunt insertion and endoscopic third ventriculostomy) and during the course of recovery after surgery in association with neuropsychological and behavioral outcome. METHODS This prospective study included 54 pediatric patients with congenital hydrocephalus (21 female, 33 male; age range 0.03–194.5 months) who underwent surgery and 64 normal controls (30 female, 34 male; age range 0.30–197.75 months). DTI and neurodevelopmental outcome data were collected once in the control group and 3 times (preoperatively and at 3 and 12 months postoperatively) in the patients with hydrocephalus. DTI measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values were extracted from the genu of the corpus callosum (gCC) and the posterior limb of internal capsule (PLIC). Group analysis was performed first cross-sectionally to quantify DTI abnormalities at 3 time points by comparing the data obtained in the hydrocephalus group for each of the 3 time points to data obtained in the controls. Longitudinal comparisons were conducted pairwise between different time points in patients whose data were acquired at multiple time points. Neurodevelopmental data were collected and analyzed using the Adaptive Behavior Assessment System, Second Edition, and the Bayley Scales of Infant Development, Third Edition. Correlation analyses were performed between DTI and behavioral measures. RESULTS Significant DTI abnormalities were found in the hydrocephalus patients in both the gCC (lower FA and higher MD, AD, and RD) and the PLIC (higher FA, lower AD and RD) before surgery. The DTI measures in the gCC remained mostly abnormal at 3 and 12 months after surgery. The DTI abnormalities in the PLIC were significant in FA and AD at 3 months after surgery but did not persist when tested at 12 months after surgery. Significant longitudinal DTI changes in the patients with hydrocephalus were found in the gCC when findings at 3 and 12 months after surgery were compared. In the PLIC, trend-level longitudinal changes were observed between preoperative findings and 3-month postoperative findings, as well as between 3- and 12-month postoperative findings. Significant correlation between DTI and developmental outcome was found at all 3 time points. Notably, a significant correlation was found between DTI in the PLIC at 3 months after surgery and developmental outcome at 12 months after surgery. CONCLUSIONS The data showed significant WM abnormality based on DTI in both the gCC and the PLIC in patients with congenital hydrocephalus before surgery, and the abnormalities persisted in both the gCC and the PLIC at 3 months after surgery. The DTI values remained significantly abnormal in the gCC at 12 months after surgery. Longitudinal analysis showed signs of recovery in both WM structures between different time points. Combined with the significant correlation found between DTI and neuropsychological measures, the findings of this study suggest that DTI can serve as a sensitive imaging biomarker for underlying neuroanatomical changes and postsurgical developmental outcome and even as a predictor for future outcomes.

show abstract

Section: Discussionmentioning

confidence: 50%

Diffusion tensor imaging study of pediatric patients with congenital hydrocephalus: 1-year postsurgical outcomes

Mangano

Altaye

McKinstry

et al. 2016

PED

View full text Add to dashboard Cite

show abstract

“…[14][15][16] Previous DTI studies of WM development have been limited by small numbers of pediatric patients, inclusion of data from multiple institutions, combination of adult and pediatric data, or inclusion of potentially biasing pathologies without further follow-up. 4,8,13,[17][18][19][20][21][22] The aim of our study was, thus, to report a representative dataset of normal age-related changes in FA and MD values detected in the developing brain, derived from 202 healthy participants ranging in age from birth to adolescence.…”

mentioning

confidence: 99%

DTI Values in Key White Matter Tracts from Infancy through Adolescence

Cancelliere

Mangano²,

Air³

et al. 2013

AJNR Am J Neuroradiol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Serial DTI evaluation can also be diagnostic over time as well as prognostic: DTI changes normalize with time in benign external hydrocephalus, distinguishing it from progressive hydrocephalus [111]. …”

Section: Quantitative Mrimentioning

confidence: 99%

Preterm neuroimaging and neurodevelopmental outcome: a focus on intraventricular hemorrhage, post-hemorrhagic hydrocephalus, and associated brain injury

Dorner¹,

Burton

Allen

et al. 2018

J Perinatol

View full text Add to dashboard Cite

Intraventricular hemorrhage in the setting of prematurity remains the most common cause of acquired hydrocephalus. Neonates with progressive post-hemorrhagic hydrocephalus are at risk for adverse neurodevelopmental outcomes. The goal of this review is to describe the distinct and often overlapping types of brain injury in the preterm neonate, with a focus on neonatal hydrocephalus, and to connect injury on imaging to neurodevelopmental outcome risk. Head ultrasound and magnetic resonance imaging findings are described separately. The current state of the literature is imprecise and we end the review with recommendations for future radiologic and neurodevelopmental research.

show abstract

Diffusion tensor imaging findings in young children with benign external hydrocephalus differ from the normal population

Cited by 22 publications

References 37 publications

Diffusion tensor imaging study of pediatric patients with congenital hydrocephalus: 1-year postsurgical outcomes

Diffusion tensor imaging study of pediatric patients with congenital hydrocephalus: 1-year postsurgical outcomes

DTI Values in Key White Matter Tracts from Infancy through Adolescence

Preterm neuroimaging and neurodevelopmental outcome: a focus on intraventricular hemorrhage, post-hemorrhagic hydrocephalus, and associated brain injury

Contact Info

Product

Resources

About