Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice

Islam, Mohammad Rashedul; Luo, Renhao; Valaris, Sophia; Haley, Erin B.; Takase, Hajime; Chen, Yin-Ching Iris; Dickerson, Bradford C.; Schön, Karin; Arai, Ken; Nguyen, Christopher; Wrann, Christiane D.

doi:10.3233/bpl-190090

Cited by 11 publications

(8 citation statements)

References 70 publications

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“…In contrast, no impact of exercise could be detected in ROI located in GM. Previous research has shown that aerobic excise positively correlates with FA values measured with DTI in healthy individuals/animals ( Johnson et al, 2012 ; Chaddock-Heyman et al, 2018 ; Islam et al, 2020 ). Our study is the first DTI study that recapitulates the positive effects of voluntary exercise on WM fiber integrity in stroke induced mice.…”

Section: Discussionmentioning

confidence: 92%

The Impact of Voluntary Exercise on Stroke Recovery

et al. 2021

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Stroke treatment is limited to time-critical thrombectomy and rehabilitation by physiotherapy. Studies report beneficial effects of exercise; however, a knowledge gap exists regarding underlying mechanisms that benefit recovery of brain networks and cognition. This study aims to unravel therapeutic effects of voluntary exercise in stroke-induced mice to develop better personalized treatments. Male C57Bl6/JOlaHsd mice were subjected to transient middle cerebral artery occlusion. After surgery, the animals were divided in a voluntary exercise group with access to running wheels (RW), and a control group without running wheels (NRW). During 6 days post-stroke, activity/walking patterns were measured 24/7 in digital ventilated cages. Day 7 post-surgery, animals underwent MRI scanning (11.7T) to investigate functional connectivity (rsfMRI) and white matter (WM) integrity (DTI). Additionally, postmortem polarized light imaging (PLI) was performed to quantify WM fiber density and orientation. After MRI the animals were sacrificed and neuroinflammation and cerebral vascularisation studied. Voluntary exercise promoted myelin density recovery corresponding to higher fractional anisotropy. The deteriorating impact of stroke on WM dispersion was detected only in NRW mice. Moreover, rsfMRI revealed increased functional connectivity, cerebral blood flow and vascular quality leading to improved motor skills in the RW group. Furthermore, voluntary exercise showed immunomodulatory properties post-stroke. This study not only helped determining the therapeutic value of voluntary exercise, but also provided understanding of pathological mechanisms involved in stroke.

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Section: Discussionmentioning

confidence: 92%

The Impact of Voluntary Exercise on Stroke Recovery

et al. 2021

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“…Moreover, just as it happens with learning, depending on the frequency of stimulation (or repetition of conduct), these initial dynamic neuro-plastic adaptations can develop into more stable structural adaptations (i.e., WM integrity above). In other words, the initial neuroplastic changes at the functional level might foment longer-term protective adaptations that can persist for months or years ( Islam et al, 2020 ; Wilde et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

The impact of loneliness and social adaptation on depressive symptoms: Behavioral and brain measures evidence from a brain health perspective

́Byrne

Gonzalez-Gomez²,

Sepúlveda³

et al. 2023

Front. Psychol.

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IntroductionEarly detection of depression is a cost-effective way to prevent adverse outcomes on brain physiology, cognition, and health. Here we propose that loneliness and social adaptation are key factors that can anticipate depressive symptoms.MethodsWe analyzed data from two separate samples to evaluate the associations between loneliness, social adaptation, depressive symptoms, and their neural correlates.ResultsFor both samples, hierarchical regression models on self-reported data showed that loneliness and social adaptation have negative and positive effects on depressive symptoms. Moreover, social adaptation reduces the impact of loneliness on depressive symptoms. Structural connectivity analysis showed that depressive symptoms, loneliness, and social adaptation share a common neural substrate. Furthermore, functional connectivity analysis demonstrated that only social adaptation was associated with connectivity in parietal areas.DiscussionAltogether, our results suggest that loneliness is a strong risk factor for depressive symptoms while social adaptation acts as a buffer against the ill effects of loneliness. At the neuroanatomical level, loneliness and depression may affect the integrity of white matter structures known to be associated to emotion dysregulation and cognitive impairment. On the other hand, socio-adaptive processes may protect against the harmful effects of loneliness and depression. Structural and functional correlates of social adaptation could indicate a protective role through long and short-term effects, respectively. These findings may aid approaches to preserve brain health via social participation and adaptive social behavior.

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“…For example, mice with access to a running wheel exhibit a significant increase in hippocampal neurogenesis and enhanced spatial and temporal memory [ 27 ]. Magnetic resonance imaging (MRI) studies revealed that extended voluntary exercise increases hippocampal volume in mice [ 28 ]. Similar findings were also reported in human studies.…”

Section: Exercise-induced Factors and Neural Plasticitymentioning

confidence: 99%

Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling

Fakhoury

Eid

Ahmad

et al. 2022

BPL

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The term “neural plasticity” was first used to describe non-pathological changes in neuronal structure. Today, it is generally accepted that the brain is a dynamic system whose morphology and function is influenced by a variety of factors including stress, diet, and exercise. Neural plasticity involves learning and memory, the synthesis of new neurons, the repair of damaged connections, and several other compensatory mechanisms. It is altered in neurodegenerative disorders and following damage to the central or peripheral nervous system. Understanding the mechanisms that regulate neural plasticity in both healthy and diseased states is of significant importance to promote cognition and develop rehabilitation techniques for functional recovery after injury. In this minireview, we will discuss the mechanisms by which environmental factors promote neural plasticity with a focus on exercise- and diet-induced factors. We will highlight the known circulatory factors that are released in response to exercise and discuss how all factors activate pathways that converge in part on the activation of BDNF signaling. We propose to harness the therapeutic potential of exercise by using BDNF as a biomarker to identify novel endogenous factors that promote neural plasticity. We also discuss the importance of combining exercise factors with dietary factors to develop a lifestyle pill for patients afflicted by CNS disorders.

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Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice

Cited by 11 publications

References 70 publications

The Impact of Voluntary Exercise on Stroke Recovery

The Impact of Voluntary Exercise on Stroke Recovery

The impact of loneliness and social adaptation on depressive symptoms: Behavioral and brain measures evidence from a brain health perspective

Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling

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