2017
DOI: 10.1148/radiol.2016152613
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Diffusion Tractography of the Entire Left Ventricle by Using Free-breathing Accelerated Simultaneous Multisection Imaging

Abstract: Purpose To develop a clinically feasible whole-heart free-breathing diffusion-tensor (DT) magnetic resonance (MR) imaging approach, with an imaging time of approximately 15 minutes to enable three-dimensional (3D) tractography. Materials and Methods The study was compliant with HIPAA and the institutional review board and required written consent from the participants. DT imaging was performed in seven healthy volunteers and three patients with pulmonary hypertension by using a stimulated echo sequence. Twel… Show more

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Cited by 38 publications
(46 citation statements)
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“…Large variations in heart rate may lead to more averages containing signal voids (in contrast to Supporting Information Figure ), due to a significant mismatch in configuration between the 2 diffusion‐encoding gradients in STEAM imaging. Images with such signal voids need to be discarded before processing . Most clinical systems allow for collecting physiological data alongside imaging data, to take b ‐value variations into account during postprocessing …”
Section: Discussionmentioning
confidence: 99%
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“…Large variations in heart rate may lead to more averages containing signal voids (in contrast to Supporting Information Figure ), due to a significant mismatch in configuration between the 2 diffusion‐encoding gradients in STEAM imaging. Images with such signal voids need to be discarded before processing . Most clinical systems allow for collecting physiological data alongside imaging data, to take b ‐value variations into account during postprocessing …”
Section: Discussionmentioning
confidence: 99%
“…Images with such signal voids need to be discarded before processing. 23,37 Most clinical systems allow for collecting physiological data alongside imaging data, to take b-value variations into account during postprocessing. 38,39 Our study has limitations.…”
Section: Discussionmentioning
confidence: 99%
“…For clinical acceptance, the scan time will need to be significantly reduced. We recently demonstrated DTI with whole‐heart coverage in 15 minutes using both in‐plane and through‐plane acceleration 23. We anticipate that further reductions in scan time will be possible with ongoing advances in technology.…”
Section: Discussionmentioning
confidence: 99%
“…Acquisition parameters included field of view, 360×200 mm 2 ; spatial resolution, 2.5×2.5 mm 2 ; slice thickness, 8 mm; in‐plane acceleration rate, 2; repetition time, 2 × cardiac cycle length (ms); echo time, 34 ms; b values, 0 and 500 s/mm 2 ; 10 diffusion‐encoding directions; and 8 averages. The entire left ventricle (LV) was imaged without slice gaps by acquiring 12 contiguous short‐axis slices from base to apex 23. Images were acquired in the systolic and diastolic sweet spots of the cardiac cycle to mitigate strain effects 18, 22…”
Section: Methodsmentioning
confidence: 99%
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