Diffusion-Weighted Imaging of Mucinous Carcinoma of the Breast: Evaluation of Apparent Diffusion Coefficient and Signal Intensity in Correlation With Histologic Findings

Woodhams, Reiko; Kakita, Satoko; Hata, Hirofumi; Iwabuchi, Kazuya; Umeoka, Shigeaki; Mountford, Carolyn E.; Hatabu, Hiroto

doi:10.2214/ajr.08.1670

Cited by 155 publications

(126 citation statements)

References 19 publications

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“…Woodhams et al measured higher ADC values in mucinous carcinomas in comparison to other malignant lesions. In their study pure mucinous carcinomas had even higher ADC values than the majority of benign lesions [24]. In our study both pure type mucinous carcinomas revealed ADC values not noticeably different from benign lesions ( • " Fig.…”

supporting

confidence: 58%

Diffusion-Weighted MR Imaging of Benign and Malignant Breast Lesions Before and After Contrast Enhancement

Janka

Hammon

Geppert

et al. 2013

Fortschr Röntgenstr

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Mamma 130Janka R et al. 50, 400 und 800) wurde vor und nach KM-Gabe gemessen und die entsprechenden ADC-Werte der Läsionen verglichen. Vor der Berechnung der ADC-Werte wurden die Läsionen bezüglich ihrer konstanten Lokalisation in den diffusionsgewichteten Sequenzen analysiert. Ergebnisse: Die mittlere Größe der Läsionen war 1,5 ± 0,8 cm. Auf der Basis der b50-und b400-Messung betrug der durchschnittliche ADC-Wert der benignen Läsionen 1,89 ± 0,30 × 10 -3 mm 2 /s vor und 1,85 ± 0,28 × 10 -3 mm 2 /s nach KM-Gabe. Die entsprechenden Werte für zwei muzinöse Karzinome betrugen 1,88 × 10 -3 mm 2 /s und 1,81 × 10 3 mm 2 /s und für die übrigen malignen Läsionen 1,00 ± 0,18 × 10 -3 mm 2 /s und 0,88 ± 0,21 × 10 -3 mm 2 . Auf der Basis der b50-, b400-und b800-Messung betrug der durchschnittliche ADC-Wert der benignen Läsionen 1,99 ± 0,37 × 10 -3 mm 2 /s vor und 1,97 ± 0,30 × 10 -3 mm 2 /s nach KM-Gabe. Der mittlere ADC-Wert der malignen Läsionen betrug 0,90 ± 0,14 × 10 -3 mm 2 /s vor und 0,80 ± 0,14 × 10 -3 mm 2 /s nach KM-Gabe. Während der ADC-Wert der gutartigen Läsionen durch das Kontrastmittel nicht signifikant beinflusst wurde, war er bei den malignen Läsionen nach Kontrastmittelgabe signifikant niedriger. Abstract !Purpose: Many publications describe the use of diffusion-weighted imaging (DWI) in breast MRI. This article addresses the question of when to apply the DWI sequence in the course of the scan protocol. The effect of T1-shortening contrast media (CM) on the ADC values of breast lesions is investigated. Materials and Methods: Data were acquired on a 1.5 T scanner. 60 patients with 79 lesions (20 benign, 59 malignant) were included. The DWI sequence (4 mm slice thickness, b-values: 50, 400, 800) was applied before and after CM administration. Before calculating the ADC map, the b50, b400 and b800 series were analyzed concerning lesion displacement. ADC values before and after CM application were compared.

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supporting

confidence: 58%

Diffusion-Weighted MR Imaging of Benign and Malignant Breast Lesions Before and After Contrast Enhancement

Janka

Hammon

Geppert

et al. 2013

Fortschr Röntgenstr

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“…The single mucinous carcinoma identified in our study had a higher mean ADC than the other types of breast cancers, even some of the benign lesions. This is consistent with the results of previous studies (Woodhams et al, 2009;Kul et al, 2011). Altough, the reason is not clear in the literature, there are other studies that showed similar low ADC values in fat necrosis as presented in our study (Kul et al, 2011;Fornasa et al, 2011).…”

Section: Discussionsupporting

confidence: 92%

“…In this special type of breast cancer, the presence of both low cellularity and mucin-rich compartments has been proposed to be responsible for this higher ADC value (Woodhams et al, 2009). The single mucinous carcinoma identified in our study had a higher mean ADC than the other types of breast cancers, even some of the benign lesions.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of apparent diffusion coefficients to differentiate benign and malignant breast lesions

Polat¹,

Ozbay²,

Aydin³

et al. 2014

jecm

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“…19 One reason our results diŠer may be because they included special type breast cancers other than IDC, but we excluded such special types. For example, mucinous carcinomas show higher ADC values than IDC, 7,20 but lymph node metastasis of mucinous carcinoma of the breast is rare. 21 DiŠerences in tumor size might also aŠect the results, but Kim's group did not detail tumor size.…”

Section: Discussionmentioning

confidence: 99%

Correlations between Apparent Diffusion Coefficient Values and Prognostic Factors of Breast Cancer

et al. 2013

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Purpose: We investigated possible correlations between apparent diŠusion coe‹cient (ADC) values and prognostic factors of breast cancer.Methods: We retrospectively evaluated 81 patients who underwent magnetic resonance (MR) imaging of the breast and were diagnosed pathologically with invasive ductal carcinoma (IDC) not otherwise speciˆed with invasive foci one cm or larger. We excluded ductal carcinoma in situ and IDC with invasive foci smaller than one cm because small lesions decrease the reliability of signal intensity of diŠusion-weighted imaging (DWI). We also excluded special type cancers. We used t-test to compare the mean ADC values of cancers of Stage pT1 (Ã2 cm) versus pT2 or 3 (À2 cm), cancers with versus without vascular invasion, axillary lymph node (N)-positive versus N-negative cancers, estrogen receptor (ER)-positive versus ER-negative cancers, and progesterone receptor (PgR)-positive versus PgRnegative cancers. We analyzed correlations between the ADC value with nuclear grade (NG) and human epidermal growth factor receptor 2 (HER2) score by rank test using Spearman's correlation coe‹cient.Results: The mean ADC value was signiˆcantly higher for N-positive (n＝28; 0.97±0.20 ×10 -3 mm 2 /s) than N-negative cancers (n＝53; 0.87±0.17×10 Conclusion: ADC values were higher for N-positive and ER-negative breast cancers than N-negative and ER-positive cancers.

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Diffusion-Weighted Imaging of Mucinous Carcinoma of the Breast: Evaluation of Apparent Diffusion Coefficient and Signal Intensity in Correlation With Histologic Findings

Cited by 155 publications

References 19 publications

Diffusion-Weighted MR Imaging of Benign and Malignant Breast Lesions Before and After Contrast Enhancement

Diffusion-Weighted MR Imaging of Benign and Malignant Breast Lesions Before and After Contrast Enhancement

Diagnostic value of apparent diffusion coefficients to differentiate benign and malignant breast lesions

Correlations between Apparent Diffusion Coefficient Values and Prognostic Factors of Breast Cancer

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